Fluoride Poison

Is Fluoridation Coming to Britain?

2008-02-11T12:42:00.001-08:00

UK Health Secretary Alan Johnson has called for fluoride to be added to England's water supplies. His is asking strategic health authorities (SHAs) to compel water companies to add the chemical. At present, only about 10 percent of England's water is fluoridated.

However, critics of the move argue that there may be long term health risks to fluoridation. They have pointed to research indicating possible heightened risks of cancer, infertility and bone fractures. Excess fluoride is also known to be associated with discoloration of the teeth, a condition known as fluorosis.

Johnson argued that fluoridation has been in operation since the 1940s in the U.S. with no ill effect.

Scientific American Has Second Thoughts About Fluoride

2008-01-22T08:15:00.000-08:00

Editors for Scientific American believe recent studies suggest that fluoride raises the risks of disorders affecting teeth, bones, the brain and the thyroid gland, and in general “scientific attitudes” about fluoridation may be shifting.

"Fluoride, the most consumed drug in the USA, is deliberately added to 2/3 of public water supplies theoretically to reduce tooth decay, but with no scientifically-valid evidence proving safety or effectiveness," says lawyer Paul Beeber, president of the New York State Coalition Opposed to Fluoridation.

Meanwhile, according to environmental reporter and director of New York University's Science, Health and Environmental Reporting Program Dan Fagin, "There is no universally accepted optimal level for daily intake of fluoride."

After analyzing hundreds of fluoride studies, researchers found that fluoride:

* Alters endocrine function, especially in the thyroid
* Causes dental fluorosis in young children
* May lower IQ
* May increase the risk of bone fractures

Because scientific evidence suggests that water fluoridation is ineffective and dangerous to health, over 1,200 professional are now urging Congress to stop water fluoridation.
Sources:

* Reuters January 2, 2008

If more Americans knew that fluoride, which many dentists STILL mistakenly promote as the panacea for healthy teeth, is also the active toxin in rat poisons and cockroach powder, I suspect they would feel vastly different about ingesting it via drinking water and toothpaste.

But FINALLY the tides do seem to be turning.

In 2005, eleven unions within the EPA publicly called for a ban of water fluoridation, over concerns that it may cause bone cancer. And in 2006, the American Dental Association warned parents of infants not to use fluoridated water when mixing baby formula.

When you begin to examine the evidence surrounding water fluoridation, this gradual retraction makes perfect sense.

As award-winning journalist Christopher Bryson revealed in his book The Fluoride Deception, there has been a multi-tiered effort -- or as Bryson says, an abuse of power -- by military and industry scientists and public health officials to shamelessly promote fluoride to the dentistry field and the American public with little regard to the implications it would have on human health.

Just what are those potential implications?

* An increased risk of bone cancer
* Fluorosis, a discoloring of your teeth and breakdown of their enamel (between 30 percent and 50 percent of children have dental fluorosis on at least two teeth in “optimally fluoridated communities”)
* An increased risk of osteoporosis
* Developmental problems such as lower IQ

But that’s not all. According to Paul Connett, PhD:

1. Fluoride accumulates in your bones and makes them more brittle and prone to fracture. Lifetime exposure to fluoride will contribute to higher rates of hip fracture in the elderly.

2. Fluoride accumulates in your pineal gland, possibly lowering the production of melatonin, a very important regulatory hormone

3. There are serious concerns about a connection between fluoridation and the current epidemics of both arthritis and hypothyroidism.

4. In animal studies fluoride at 1 ppm in drinking water increases the uptake of aluminum into your brain.

5. Counties with 3 ppm or more of fluoride in their water have lower fertility rates.

6. The fluoridating agents most commonly used in the United States not only increase the uptake of lead into children's blood but are also associated with an increase in violent behavior.

Of course, the main reason why fluoride is reportedly added to the U.S. water supply in the first place is to prevent cavities. Yet, data compiled by the World Health Organization shows no difference in tooth decay in countries that use fluoridated water compared with countries that don’t use fluoridated water. So not only is fluoride unsafe, it is ineffective as well.

Get That Fluoride Out of Your Water!

If you are receiving your water from a municipal water supply in the United States, your water is probably fluoridated -- and a simple carbon filter will not remove it.

You must filter your tap water with a reverse osmosis filter to remove fluoride, and remember to use this water not only for drinking but also for washing fruits and veggies, making ice cubes and cooking.

You can also join the fight against water fluoridation by supporting the Fluoride Action Network’s petition to end water fluoridation. It’s already been signed by over 1,200 professionals, including a Nobel Prize winner, three officers in the union representing professionals at EPA headquarters, the executive board of the American Academy of Environmental Medicine, leading fluoride researchers, and medical, dental, scientific and environmental professionals from around the world.

To voice your opinion against water fluoridation, simply send this immediate e-mail to your senators and representative.

Pesticides use Fluoride as main ingredient!

2007-12-23T13:57:00.000-08:00

Common pesticides use fluoridation chemicals as their main ingredient

Fluoridation chemicals are used in pesticides and in toothpaste! Here's a few examples.

Product: REXCO ROACH DEATH
EPA Registration Number: 03025708880
This pesticide is used as a: Insecticide and Miticide
This pesticide's toxicity code is 1, which corresponds to a toxicity category of Danger.
Active Ingredient: SODIUM FLUORIDE 40% (% by mass)

Product: ROACHES LAST MEAL
EPA Registration Number: 01080000001
This pesticide is used as a: Insecticide and Miticide
Active Ingredients: SODIUM FLUORIDE 40%

Product: BUG-NO-MOR (POWDER)
EPA Registration Number: 02524207637
This pesticide is used as a: Insecticide and Miticide
Active Ingredients: PYRETHRUM 50%, SODIUM FLUORIDE 45%

Product: OSMOPLASTIC WOOD PRESERVING COMPOUND
EPA Registration Number: 00300800056
This pesticide is used as a: Fungicide
Active Ingredients: SODIUM FLUORIDE 44.42%, CREOSOTES 45.62%

50 Reasons to Oppose Fluoridation

2007-12-17T12:53:00.001-08:00

50 Reasons to Oppose Fluoridation

50 Reasons to Oppose Fluoridation
Updated April 12, 2004

by Paul Connett, PhD
Professor of Chemistry
St. Lawrence University
Canton, NY 13617

1) Fluoride is not an essential nutrient (NRC 1993 and IOM 1997). No disease has ever been linked to a fluoride deficiency. Humans can have perfectly good teeth without fluoride.

2) Fluoridation is not necessary. Most Western European countries are not fluoridated and have experienced the same decline in dental decay as the US (See data from World Health Organization in Appendix 1, and the time trends presented graphically at http://www.fluoridealert.org/who-dmft.htm ). The reasons given by countries for not fluoridating are presented in Appendix 2.)

3) Fluoridation's role in the decline of tooth decay is in serious doubt. The largest survey ever conducted in the US (over 39,000 children from 84 communities) by the National Institute of Dental Research showed little difference in tooth decay among children in fluoridated and non-fluoridated communities (Hileman 1989). According to NIDR researchers, the study found an average difference of only 0.6 DMFS (Decayed Missing and Filled Surfaces) in the permanent teeth of children aged 5-17 residing in either fluoridated or unfluoridated areas (Brunelle and Carlos, 1990). This difference is less than one tooth surface! There are 128 tooth surfaces in a child's mouth. This result was not shown to be statistically significant. In a review commissioned by the Ontario government, Dr. David Locker concluded:

"The magnitude of [fluoridation's] effect is not large in absolute terms, is often not statistically significant and may not be of clinical significance" (Locker 1999).

4) Where fluoridation has been discontinued in communities from Canada, the former East Germany, Cuba and Finland, dental decay has not increased but has actually decreased (Maupome 2001; Kunzel and Fischer,1997,2000; Kunzel 2000 and Seppa 2000).

5) There have been numerous recent reports of dental crises in US cities (e.g. Boston, Cincinnati, New York City) which have been fluoridated for over 20 years. There appears to be a far greater (inverse) relationship between tooth decay and income level than with water fluoride levels.

6) Modern research (e.g. Diesendorf 1986; Colquhoun 1997, and De Liefde, 1998) shows that decay rates were coming down before fluoridation was introduced and have continued to decline even after its benefits would have been maximized. Many other factors influence tooth decay. Some recent studies have found that tooth decay actually increases as the fluoride concentration in the water increases (Olsson 1979; Retief 1979; Mann 1987, 1990; Steelink 1992; Teotia 1994; Grobleri 2001; Awadia 2002 and Ekanayake 2002).

7) The Centers for Disease Control and Prevention (CDC 1999, 2001) has now acknowledged the findings of many leading dental researchers, that the mechanism of fluoride's benefits are mainly TOPICAL not SYSTEMIC. Thus, you don't have to swallow fluoride to protect teeth. As the benefits of fluoride (if any exist) are topical, and the risks are systemic, it makes more sense, for those who want to take the risks, to deliver the fluoride directly to the tooth in the form of toothpaste. Since swallowing fluoride is unnecessary, there is no reason to force people (against their will) to drink fluoride in their water supply. This position was recently shared by Dr. Douglas Carnall, the associate editor of the British Medical Journal. His editorial appears in Appendix 3.

8) Despite being prescribed by doctors for over 50 years, the US Food and Drug Administration (FDA) has never approved any fluoride product designed for ingestion as safe or effective. Fluoride supplements are designed to deliver the same amount of fluoride as ingested daily from fluoridated water (Kelly 2000).

9) The US fluoridation program has massively failed to achieve one of its key objectives, i.e. to lower dental decay rates while holding down dental fluorosis (mottled and discolored enamel), a condition known to be caused by fluoride. The goal of the early promoters of fluoridation was to limit dental fluorosis (in its mildest form) to 10% of children (NRC 1993, pp. 6-7). A major US survey has found 30% of children in optimally fluoridated areas had dental fluorosis on at least two teeth (Heller 1997), while smaller studies have found up to 80% of children impacted (Williams 1990; Lalumandier 1995 and Morgan 1998). The York Review estimates that up to 48% of children in optimally fluoridated areas worldwide have dental fluorosis in all forms and 12.5% with symptoms of aesthetic concern (McDonagh, 2000).

10) Dental fluorosis means that a child has been overdosed on fluoride. While the mechanism by which the enamel is damaged is not definitively known, it appears fluorosis may be a result of either inhibited enzymes in the growing teeth (Dan Besten 1999), or through fluoride's interference with G-protein signaling mechanisms (Matsuo 1996). In a study in Mexico, Alarcon-Herrera (2001) has shown a linear correlation between the severity of dental fluorosis and the frequency of bone fractures in children.

11) The level of fluoride put into water (1 ppm) is up to 200 times higher than normally found in mothers' milk (0.005 – 0.01 ppm) (Ekstrand 1981; Institute of Medicine 1997). There are no benefits, only risks, for infants ingesting this heightened level of fluoride at such an early age (this is an age where susceptibility to environmental toxins is particularly high).

12) Fluoride is a cumulative poison. On average, only 50% of the fluoride we ingest each day is excreted through the kidneys. The remainder accumulates in our bones, pineal gland, and other tissues. If the kidney is damaged, fluoride accumulation will increase, and with it, the likelihood of harm.

13) Fluoride is very biologically active even at low concentrations. It interferes with hydrogen bonding (Emsley 1981) and inhibits numerous enzymes (Waldbott 1978).

14) When complexed with aluminum, fluoride interferes with G-proteins (Bigay 1985, 1987). Such interactions give aluminum-fluoride complexes the potential to interfere with many hormonal and some neurochemical signals (Strunecka & Patocka 1999, Li 2003).

15) Fluoride has been shown to be mutagenic, cause chromosome damage and interfere with the enzymes involved with DNA repair in a variety of cell and tissue studies (Tsutsui 1984; Caspary 1987; Kishi 1993 and Mihashi 1996). Recent studies have also found a correlation between fluoride exposure and chromosome damage in humans (Sheth 1994; Wu 1995; Meng 1997 and Joseph 2000).

16) Fluoride forms complexes with a large number of metal ions, which include metals which are needed in the body (like calcium and magnesium) and metals (like lead and aluminum) which are toxic to the body. This can cause a variety of problems. For example, fluoride interferes with enzymes where magnesium is an important co-factor, and it can help facilitate the uptake of aluminum and lead into tissues where these metals wouldn't otherwise go (Mahaffey 1976; Allain 1996; Varner 1998).

17) Rats fed for one year with 1 ppm fluoride in their water, using either sodium fluoride or aluminum fluoride, had morphological changes to their kidneys and brains, an increased uptake of aluminum in the brain, and the formation of beta amyloid deposits which are characteristic of Alzheimers disease (Varner 1998).

18) Aluminum fluoride was recently nominated by the Environmental Protection Agency and National Institute of Environmental Health Sciences for testing by the National Toxicology Program. According to EPA and NIEHS, aluminum fluoride currently has a "high health research priority" due to its "known neurotoxicity" (BNA, 2000). If fluoride is added to water which contains aluminum, than aluminum fluoride complexes will form.

19) Animal experiments show that fluoride accumulates in the brain and exposure alters mental behavior in a manner consistent with a neurotoxic agent (Mullenix 1995). Rats dosed prenatally demonstrated hyperactive behavior. Those dosed postnatally demonstrated hypoactivity (i.e. under activity or "couch potato" syndrome). More recent animal experiments have reported that fluoride can damage the brain (Wang 1997; Guan 1998; Varner 1998; Zhao 1998; Zhang 1999; Lu 2000; Shao 2000; Sun 2000; Bhatnagar 2002; Chen 2002, 2003; Long 2002; Shivarajashankara 2002a, b; Shashi 2003 and Zhai 2003) and impact learning and behavior (Paul 1998; Zhang 1999, 2001; Sun 2000; Ekambaram 2001; Bhatnagar 2002).

20) Five studies from China show a lowering of IQ in children associated with fluoride exposure (Lin Fa-Fu 1991; Li 1995; Zhao 1996; Lu 2000; and Xiang 2003a, b). One of these studies (Lin Fa-Fu 1991) indicates that even just moderate levels of fluoride exposure (e.g. 0.9 ppm in the water) can exacerbate the neurological defects of iodine deficiency.

21) Studies by Jennifer Luke (2001) showed that fluoride accumulates in the human pineal gland to very high levels. In her Ph.D. thesis Luke has also shown in animal studies that fluoride reduces melatonin production and leads to an earlier onset of puberty (Luke 1997).

22) In the first half of the 20th century, fluoride was prescribed by a number of European doctors to reduce the activity of the thyroid gland for those suffering from hyperthyroidism (over active thyroid) (Stecher 1960; Waldbott 1978). With water fluoridation, we are forcing people to drink a thyroid-depressing medication which could, in turn, serve to promote higher levels of hypothyroidism (underactive thyroid) in the population, and all the subsequent problems related to this disorder. Such problems include depression, fatigue, weight gain, muscle and joint pains, increased cholesterol levels, and heart disease.

It bears noting that according to the Department of Health and Human Services (1991) fluoride exposure in fluoridated communities is estimated to range from 1.6 to 6.6 mg/day, which is a range that actually overlaps the dose (2.3 - 4.5 mg/day) shown to decrease the functioning of the human thyroid (Galletti & Joyet 1958). This is a remarkable fact, particularly considering the rampant and increasing problem of hypothyroidism in the United States (in 1999, the second most prescribed drug of the year was Synthroid, which is a hormone replacement drug used to treat an underactive thyroid). In Russia, Bachinskii (1985) found a lowering of thyroid function, among otherwise healthy people, at 2.3 ppm fluoride in water.

23) Some of the early symptoms of skeletal fluorosis, a fluoride-induced bone and joint disease that impacts millions of people in India, China, and Africa , mimic the symptoms of arthritis (Singh 1963; Franke 1975; Teotia 1976; Carnow 1981; Czerwinski 1988; DHHS 1991). According to a review on fluoridation by Chemical & Engineering News, "Because some of the clinical symptoms mimic arthritis, the first two clinical phases of skeletal fluorosis could be easily misdiagnosed" (Hileman 1988). Few if any studies have been done to determine the extent of this misdiagnosis, and whether the high prevalence of arthritis in America (1 in 3 Americans have some form of arthritis - CDC, 2002) is related to our growing fluoride exposure, which is highly plausible. The causes of most forms of arthritis (e.g. osteoarthritis) are unknown.

24) In some studies, when high doses of fluoride (average 26 mg per day) were used in trials to treat patients with osteoporosis in an effort to harden their bones and reduce fracture rates, it actually led to a HIGHER number of fractures, particularly hip fractures (Inkovaara 1975; Gerster 1983; Dambacher 1986; O’Duffy 1986; Hedlund 1989; Bayley 1990; Gutteridge 1990. 2002; Orcel 1990; Riggs 1990 and Schnitzler 1990). The cumulative doses used in these trials are exceeded by the lifetime cumulative doses being experienced by many people living in fluoridated communities.

25) Nineteen studies (three unpublished, including one abstract) since 1990 have examined the possible relationship of fluoride in water and hip fracture among the elderly. Eleven of these studies found an association, eight did not. One study found a dose-related increase in hip fracture as the concentration of fluoride rose from 1 ppm to 8 ppm (Li 2001). Hip fracture is a very serious issue for the elderly, as a quarter of those who have a hip fracture die within a year of the operation, while 50 percent never regain an independent existence (All 19 of these studies are referenced as a group in the reference section).

26) The only government-sanctioned animal study to investigate if fluoride causes cancer, found a dose-dependent increase in cancer in the target organ (bone) of the fluoride-treated (male) rats (NTP 1990). The initial review of this study also reported an increase in liver and oral cancers, however, all non-bone cancers were later downgraded – with a questionable rationale - by a government-review panel (Marcus 1990). In light of the importance of this study, EPA Professional Headquarters Union has requested that Congress establish an independent review to examine the study's results (Hirzy 2000).

27) A review of national cancer data in the US by the National Cancer Institute (NCI) revealed a significantly higher rate of bone cancer in young men in fluoridated versus unfluoridated areas (Hoover 1991). While the NCI concluded that fluoridation was not the cause, no explanation was provided to explain the higher rates in the fluoridated areas. A smaller study from New Jersey (Cohn 1992) found bone cancer rates to be up to 6 times higher in young men living in fluoridated versus unfluoridated areas. Other epidemiological studies have failed to find this relationship (Mahoney 1991; Freni 1992).

28) Fluoride administered to animals at high doses wreaks havoc on the male reproductive system - it damages sperm and increases the rate of infertility in a number of different species (Kour 1980; Chinoy 1989; Chinoy 1991; Susheela 1991; Chinoy 1994; Kumar 1994; Narayana 1994a, b; Zhao 1995; Elbetieha 2000; Ghosh 2002 and Zakrzewska 2002). While studies conducted at the FDA have failed to find reproductive effects in rats (Sprando 1996, 1997, 1998), an epidemiological study from the US has found increased rates of infertility among couples living in areas with 3 or more ppm fluoride in the water (Freni 1994), and 2 studies have found a reduced level of circulating testosterone in males living in high fluoride areas (Susheela 1996 and Barot 1998).

29) The fluoridation program has been very poorly monitored. There has never been a comprehensive analysis of the fluoride levels in the bones, blood, or urine of the American people or the citizens of other fluoridated countries. Based on the sparse data that has become available, however, it is increasingly evident that some people in the population – particularly people with kidney disease - are accumulating fluoride levels that have been associated with harm to both animals and humans, particularly harm to bone (see Connett 2004).

30) Once fluoride is put in the water it is impossible to control the dose each individual receives. This is because 1) some people (e.g. manual laborers, athletes, diabetics, and people with kidney disease) drink more water than others, and 2) we receive fluoride from sources other than the water supply. Other sources of fluoride include food and beverages processed with fluoridated water (Kiritsy 1996 and Heilman 1999), fluoridated dental products (Bentley 1999 and Levy 1999), mechanically deboned meat (Fein 2001), teas (Levy 1999), and pesticide residues on food (Stannard 1991 and Burgstahler 1997).

31) Fluoridation is unethical because individuals are not being asked for their informed consent prior to medication. This is standard practice for all medication, and one of the key reasons why most of western Europe has ruled against fluoridation (see appendix 2).

As one doctor aptly stated, "No physician in his right senses would prescribe for a person he has never met, whose medical history he does not know, a substance which is intended to create bodily change, with the advice: 'Take as much as you like, but you will take it for the rest of your life because some children suffer from tooth decay.’ It is a preposterous notion."

32) While referenda are preferential to imposed policies from central government, it still leaves the problem of individual rights versus majority rule. Put another way -- does a voter have the right to require that their neighbor ingest a certain medication (even if it's against that neighbor's will)?

33) Some individuals appear to be highly sensitive to fluoride as shown by case studies and double blind studies (Shea 1967, Waldbott 1978 and Moolenburg 1987). In one study, which lasted 13 years, Feltman and Kosel (1961) showed that about 1% of patients given 1 mg of fluoride each day developed negative reactions. Can we as a society force these people to ingest fluoride?

34) According to the Agency for Toxic Substances and Disease Registry (ATSDR 1993), and other researchers (Juncos & Donadio 1972; Marier & Rose 1977 and Johnson 1979), certain subsets of the population may be particularly vulnerable to fluoride's toxic effects; these include: the elderly, diabetics and people with poor kidney function. Again, can we in good conscience force these people to ingest fluoride on a daily basis for their entire lives?

35) Also vulnerable are those who suffer from malnutrition (e.g. calcium, magnesium, vitamin C, vitamin D and iodide deficiencies and protein poor diets) (Massler & Schour 1952; Marier & Rose 1977; Lin Fa-Fu 1991; Chen 1997; Teotia 1998). Those most likely to suffer from poor nutrition are the poor, who are precisely the people being targeted by new fluoridation programs. While being at heightened risk, poor families are less able to afford avoidance measures (e.g. bottled water or removal equipment).

36) Since dental decay is most concentrated in poor communities, we should be spending our efforts trying to increase the access to dental care for poor families. The real "Oral Health Crisis" that exists today in the United States, is not a lack of fluoride but poverty and lack of dental insurance. The Surgeon General has estimated that 80% of dentists in the US do not treat children on Medicaid.

37) Fluoridation has been found to be ineffective at preventing one of the most serious oral health problems facing poor children, namely, baby bottle tooth decay, otherwise known as early childhood caries (Barnes 1992 and Shiboski 2003).

38) The early studies conducted in 1945 -1955 in the US, which helped to launch fluoridation, have been heavily criticized for their poor methodology and poor choice of control communities (De Stefano 1954; Sutton 1959, 1960 and 1996; Ziegelbecker 1970). According to Dr. Hubert Arnold, a statistician from the University of California at Davis, the early fluoridation trials "are especially rich in fallacies, improper design, invalid use of statistical methods, omissions of contrary data, and just plain muddleheadedness and hebetude." In 2000, the British Government’s “York Review” could give no fluoridation trial a grade A classification – despite 50 years of research (McDonagh 2000, see Appendix 3 for commentary).

39) The US Public Health Service first endorsed fluoridation in 1950, before one single trial had been completed (McClure 1970)!

40) Since 1950, it has been found that fluorides do little to prevent pit and fissure tooth decay, a fact that even the dental community has acknowledged (Seholle 1984; Gray 1987; PHS 1993; and Pinkham 1999). This is significant because pit and fissure tooth decay represents up to 85% of the tooth decay experienced by children today (Seholle 1984 and Gray 1987).

41) Despite the fact that we are exposed to far more fluoride today than we were in 1945 (when fluoridation began), the "optimal" fluoridation level is still 1 part per million, the same level deemed optimal in 1945! (Marier & Rose 1977; Levy 1999; Rozier 1999 and Fomon 2000).

42) The chemicals used to fluoridate water in the US are not pharmaceutical grade. Instead, they come from the wet scrubbing systems of the superphosphate fertilizer industry. These chemicals (90% of which are sodium fluorosilicate and fluorosilicic acid), are classified hazardous wastes contaminated with various impurities. Recent testing by the National Sanitation Foundation suggest that the levels of arsenic in these chemicals are relatively high (up to 1.6 ppb after dilution into public water) and of potential concern (NSF 2000 and Wang 2000).

43) These hazardous wastes have not been tested comprehensively. The chemical usually tested in animal studies is pharmaceutical grade sodium fluoride, not industrial grade fluorosilicic acid. The assumption being made is that by the time this waste product has been diluted, all the fluorosilicic acid will have been converted into free fluoride ion, and the other toxics and radioactive isotopes will be so dilute that they will not cause any harm, even with lifetime exposure. These assumptions have not been examined carefully by scientists, independent of the fluoridation program.

44) Studies by Masters and Coplan (1999, 2000) show an association between the use of fluorosilicic acid (and its sodium salt) to fluoridate water and an increased uptake of lead into children's blood. Because of lead’s acknowledged ability to damage the child’s developing brain, this is a very serious finding yet it is being largely ignored by fluoridating countries.

45) Sodium fluoride is an extremely toxic substance -- just 200 mg of fluoride ion is enough to kill a young child, and just 3-5 grams (e.g. a teaspoon) is enough to kill an adult. Both children (swallowing tablets/gels) and adults (accidents involving fluoridation equipment and filters on dialysis machines) have died from excess exposure.

46) Some of the earliest opponents of fluoridation were biochemists and at least 14 Nobel Prize winners are among numerous scientists who have expressed their reservations about the practice of fluoridation (see appendix 4).

47) The recent Nobel Laureate in Medicine and Physiology, Dr. Arvid Carlsson (2000), was one of the leading opponents of fluoridation in Sweden, and part of the panel that recommended that the Swedish government reject the practice, which they did in 1971. According to Carlsson:

"I am quite convinced that water fluoridation, in a not-too-distant future, will be consigned to medical history...Water fluoridation goes against leading principles of pharmacotherapy, which is progressing from a stereotyped medication - of the type 1 tablet 3 times a day - to a much more individualized therapy as regards both dosage and selection of drugs. The addition of drugs to the drinking water means exactly the opposite of an individualized therapy" (Carlsson 1978).

48) While pro-fluoridation officials continue to promote fluoridation with undiminished fervor, they cannot defend the practice in open public debate – even when challenged to do so by organizations such as the Association for Science in the Public Interest, the American College of Toxicology, or the US Environmental Protection Agency (Bryson 2004). According to Dr. Michael Easley, a prominent lobbyist for fluoridation in the US, "Debates give the illusion that a scientific controversy exists when no credible people support the fluorophobics' view" (See appendix 5).

In light of proponents’ refusal to debate this issue, Dr. Edward Groth, a Senior Scientist at Consumers Union, observed that "the political profluoridation stance has evolved into a dogmatic, authoritarian, essentially antiscientific posture, one that discourages open debate of scientific issues" (Martin 1991).

49) Many scientists, doctors and dentists who have spoken out publicly on this issue have been subjected to censorship and intimidation (Martin 1991). Most recently, Dr. Phyllis Mullenix was fired from her position as Chair of Toxicology at Forsythe Dental Center for publishing her findings on fluoride and the brain; and Dr. William Marcus was fired from the EPA for questioning the government’s handling of the NTP’s fluoride-cancer study (Bryson 2004). Tactics like this would not be necessary if those promoting fluoridation were on secure scientific ground.

50) The Union representing the scientists at US EPA headquarters in Washington DC is now on record as opposing water fluoridation (Hirzy 1999). According to the Union’s Senior Vice President, Dr. William Hirzy:

"In summary, we hold that fluoridation is an unreasonable risk. That is, the toxicity of fluoride is so great and the purported benefits associated with it are so small - if there are any at all - that requiring every man, woman and child in America to ingest it borders on criminal behavior on the part of governments."

Conclusion

When it comes to controversies surrounding toxic chemicals, invested interests traditionally do their very best to discount animal studies and quibble with epidemiological findings. In the past, political pressures have led government agencies to drag their feet on regulating asbestos, benzene, DDT, PCBs, tetraethyl lead, tobacco and dioxins. With fluoridation we have had a fifty year delay. Unfortunately, because government officials have put so much of their credibility on the line defending fluoridation, and because of the huge liabilities waiting in the wings if they admit that fluoridation has caused an increase in hip fracture, arthritis, bone cancer, brain disorders or thyroid problems, it will be very difficult for them to speak honestly and openly about the issue. But they must, not only to protect millions of people from unnecessary harm, but to protect the notion that, at its core, public health policy must be based on sound science not political expediency. They have a tool with which to do this: it's called the Precautionary Principle. Simply put, this says: if in doubt leave it out. This is what most European countries have done and their children's teeth have not suffered, while their public's trust has been strengthened.

It is like a question from a Kafka play. Just how much doubt is needed on just one of the health concerns identified above, to override a benefit, which when quantified in the largest survey ever conducted in the US, amounts to less than one tooth surface (out of 128) in a child's mouth?

For those who would call for further studies, I say fine. Take the fluoride out of the water first and then conduct all the studies you want. This folly must end without further delay.

Postscript

Further arguments against fluoridation, can be viewed at http://www.fluoridealert.org. Arguments for fluoridation can be found at http://www.ada.org and a more systematic presentation of fluoride’s toxic effects can be found at http://www.Slweb.org/bibliography.html

Acknowledgements

I would like to acknowledge the help given to me in the research for this statement to my son Michael Connett and to Naomi Flack for the proofreading of the text. Any remaining mistakes are my own.

APPENDIX 1. World Health Organization Data

DMFT (Decayed, Missing & Filled teeth) Status for 12 year olds by Country
	DMFTs	Year	Status*
Australia	0.8	1998	More than 50% of water is fluoridated
Zurich, Switzerland	0.84	1998	Water is unfluoridated, but salt is fluoridated
Netherlands	0.9	1992-93	No water fluoridation or salt fluoridation
Sweden	0.9	1999	No water fluoridation or salt fluoridation
Denmark	0.9	2001	No water fluoridation or salt fluoridation
UK (England & Wales)	0.9	1996-97	11% of water supplies are fluoridated
Ireland	1.1	1997	More than 50% of water is fluoridated
Finland	1.1	1997	No water fluoridation or salt fluoridation
Germany	1.2	2000	No water fluoridation, but salt fluoridation is common
US	1.4	1988-91	More than 50% of water is fluoridated
Norway	1.5	1998	No water fluoridation or salt fluoridation
Iceland	1.5	1996	No water fluoridation or salt fluoridation
New Zealand	1.5	1993	More than 50% of water is fluoridated
Belgium	1.6	1998	No water fluoridation, but salt fluoridation is common
Austria	1.7	1997	No water fluoridation, but salt fluoridation is common
France	1.9	1998	No water fluoridation, but salt fluoridation is common
Data from WHO Oral Health Country/Area Profile Programme Department of Noncommunicable Diseases Surveillance/Oral Health WHO Collaborating Centre, Malmö University, Sweden http://www.whocollab.od.mah.se/euro.html

APPENDIX 2. Statements on fluoridation by governmental officials from several countries

Germany: "Generally, in Germany fluoridation of drinking water is forbidden. The relevant German law allows exceptions to the fluoridation ban on application. The argumentation of the Federal Ministry of Health against a general permission of fluoridation of drinking water is the problematic nature of compuls[ory] medication." (Gerda Hankel-Khan, Embassy of Federal Republic of Germany, September 16, 1999). www.fluoridealert.org/germany.jpeg

France: "Fluoride chemicals are not included in the list [of 'chemicals for drinking water treatment']. This is due to ethical as well as medical considerations." (Louis Sanchez, Directeur de la Protection de l'Environment, August 25, 2000). www.fluoridealert.org/france.jpeg

Belgium: "This water treatment has never been of use in Belgium and will never be (we hope so) into the future. The main reason for that is the fundamental position of the drinking water sector that it is not its task to deliver medicinal treatment to people. This is the sole responsibility of health services." (Chr. Legros, Directeur, Belgaqua, Brussels, Belgium, February 28, 2000). www.fluoridation.com/c-belgium.htm

Luxembourg: "Fluoride has never been added to the public water supplies in Luxembourg. In our views, the drinking water isn't the suitable way for medicinal treatment and that people needing an addition of fluoride can decide by their own to use the most appropriate way, like the intake of fluoride tablets, to cover their [daily] needs." (Jean-Marie RIES, Head, Water Department, Administration De L'Environment, May 3, 2000). www.fluoridealert.org/luxembourg.jpeg

Finland: "We do not favor or recommend fluoridation of drinking water. There are better ways of providing the fluoride our teeth need." (Paavo Poteri, Acting Managing Director, Helsinki Water, Finland, February 7, 2000). www.fluoridation.com/c-finland.htm

"Artificial fluoridation of drinking water supplies has been practiced in Finland only in one town, Kuopio, situated in eastern Finland and with a population of about 80,000 people (1.6% of the Finnish population). Fluoridation started in 1959 and finished in 1992 as a result of the resistance of local population. The most usual grounds for the resistance presented in this context were an individual's right to drinking water without additional chemicals used for the medication of limited population groups. A concept of "force-feeding" was also mentioned.

Drinking water fluoridation is not prohibited in Finland but no municipalities have turned out to be willing to practice it. Water suppliers, naturally, have always been against dosing of fluoride chemicals into water." (Leena Hiisvirta, M.Sc., Chief Engineer, Ministry of Social Affairs and Health, Finland, January 12, 1996.) www.fluoridealert.org/finland.jpeg

Denmark: "We are pleased to inform you that according to the Danish Ministry of Environment and Energy, toxic fluorides have never been added to the public water supplies. Consequently, no Danish city has ever been fluoridated." (Klaus Werner, Royal Danish Embassy, Washington DC, December 22, 1999). www.fluoridation.com/c-denmark.htm

Norway: "In Norway we had a rather intense discussion on this subject some 20 years ago, and the conclusion was that drinking water should not be fluoridated." (Truls Krogh & Toril Hofshagen, Folkehelsa Statens institutt for folkeheise (National Institute of Public Health) Oslo, Norway, March 1, 2000). www.fluoridation.com/c-norway.htm

Sweden: "Drinking water fluoridation is not allowed in Sweden...New scientific documentation or changes in dental health situation that could alter the conclusions of the Commission have not been shown." (Gunnar Guzikowski, Chief Government Inspector, Livsmedels Verket -- National Food Administration Drinking Water Division, Sweden, February 28, 2000). www.fluoridation.com/c-sweden.htm

Netherlands: "From the end of the 1960s until the beginning of the 1970s drinking water in various places in the Netherlands was fluoridated to prevent caries. However, in its judgement of 22 June 1973 in case No. 10683 (Budding and co. versus the City of Amsterdam) the Supreme Court (Hoge Road) ruled there was no legal basis for fluoridation. After that judgement, amendment to the Water Supply Act was prepared to provide a legal basis for fluoridation. During the process it became clear that there was not enough support from Parlement [sic] for this amendment and the proposal was withdrawn." (Wilfred Reinhold, Legal Advisor, Directorate Drinking Water, Netherlands, January 15, 2000). www.fluoridation.com/c-netherlands.htm

Northern Ireland: "The water supply in Northern Ireland has never been artificially fluoridated except in 2 small localities where fluoride was added to the water for about 30 years up to last year. Fluoridation ceased at these locations for operational reasons. At this time, there are no plans to commence fluoridation of water supplies in Northern Ireland." (C.J. Grimes, Department for Regional Development, Belfast, November 6, 2000). www.fluoridealert.org/Northern-Ireland.jpeg

Austria: "Toxic fluorides have never been added to the public water supplies in Austria." (M. Eisenhut, Head of Water Department, Osterreichische Yereinigung fur das Gas-und Wasserfach Schubertring 14, A-1015 Wien, Austria, February 17, 2000). www.fluoridation.com/c-austria.htm

Czech Republic:"Since 1993, drinking water has not been treated with fluoride in public water supplies throughout the Czech Republic. Although fluoridation of drinking water has not actually been proscribed it is not under consideration because this form of supplementation is considered as follows:

(a) uneconomical (only 0.54% of water suitable for drinking is used as such; the remainder is employed for hygiene etc. Furthermore, an increasing amount of consumers (particularly children) are using bottled water for drinking (underground water usually with fluor)

(b) unecological (environmental load by a foreign substance)

(d) toxicologically and phyiologically debateable (fluoridation represents an untargeted form of supplementation which disregards actual individual intake and requirements and may lead to excessive health-threatening intake in certain population groups; [and] complexation of fluor in water into non biological active forms of fluor." (Dr. B. Havlik, Ministerstvo Zdravotnictvi Ceske Republiky, October 14, 1999). www.fluoridealert.org/czech.jpeg

APPENDIX 3. Statement of Douglas Carnall, Associate Editor of the British Medical Journal, published on the BMJ website (http://www.bmj.com ) on the day that they published the York Review on Fluoridation.

See this review on the web at http://bmj.bmjjournals.com/cgi/content/full/321/7265/904/a

British Medical Journal, October 7, 2000, Reviews, Website of the week: Water fluoridation

Fluoridation was a controversial topic even before Kubrick's Base Commander Ripper railed against "the international communist conspiracy to sap and impurify all of our precious bodily fluids" in the 1964 film Dr Strangelove. This week's BMJ shouldn't precipitate a global holocaust, but it does seem that Base Commander Ripper may have had a point. The systematic review published this week (p 855) shows that much of the evidence for fluoridation was derived from low quality studies, that its benefits may have been overstated, and that the risk to benefit ratio for the development of the commonest side effect (dental fluorosis, or mottling of the teeth) is rather high.

Supplementary materials are available on the BMJ 's website and on that of the review's authors, enhancing the validity of the conclusions through transparency of process. For example, the "frequently asked questions" page of the site explains who comprised the advisory panel and how they were chosen ("balanced to include those for and against, as well as those who are neutral"), and the site includes the minutes of their meetings. You can also pick up all 279 references in Word97 format, and tables of data in PDF. Such transparency is admirable and can only encourage rationality of debate.

Professionals who propose compulsory preventive measures for a whole population have a different weight of responsibility on their shoulders than those who respond to the requests of individuals for help. Previously neutral on the issue, I am now persuaded by the arguments that those who wish to take fluoride (like me) had better get it from toothpaste rather than the water supply (see www.derweb.co.uk/bfs/index.html and www.npwa.freeserve.co.uk/index.html for the two viewpoints).

Douglas Carnall
Associate Editor
British Medical Journal

APPENDIX 4. List of 14 Noble Prize winners who have opposed or expressed reservations about fluoridation.

1) Adolf Butenandt (Chemistry, 1939)
2) Arvid Carlsson (Medicine, 2000)
3) Hans von Euler-Chelpin (Chemistry, 1929).
4) Walter Rudolf Hess (Medicine, 1949)
5) Corneille Jean-François Heymans (Medicine, 1938)
6) Sir Cyril Norman Hinshelwood (Chemistry, 1956)
7) Joshua Lederberg (Medicine, 1958)
8) William P. Murphy (Medicine, 1934)
8) Giulio Natta (1963 Nobel Prize in Chemistry)
10) Sir Robert Robinson (Chemistry, 1947)
11) Nikolai Semenov (Chemistry, 1956)
12) James B. Sumner (Chemistry, 1946)
13) Hugo Theorell (Medicine, 1955)
14) Artturi Virtanen (Chemistry, 1945)

APPENDIX 5. Quotes on debating fluoridation from Dr. Michael Easley, Director of the National Center for Fluoridation Policy and Research, and one of the most active proponents of fluoridation in the US (Easley 1999). Easley’s quotes typify the historic contempt that proponents have had to scientific debate.

"A favorite tactic of the fluorophobics is to argue for a debate so that 'the people can decide who is right.' Proponents of fluoride are often trapped into consenting to public debates."

"Debates give the illusion that a scientific controversy exists when no credible people support the fluorophobics' view."

"Like parasites, opponents steal undeserved credibility just by sharing the stage with respected scientists who are there to defend fluoridation"; and,

"Unfortunately, a most flagrant abuse of the public trust occasionally occurs when a physician or a dentist, for whatever personal reason, uses their professional standing in the community to argue against fluoridation, a clear violation of professional ethics, the principles of science and community standards of practice."

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Sprando RL, et al. (1997). Testing the potential of sodium fluoride to affect spermatogenesis in the rat. Food and Chemical Toxicology 35: 881-90.

Sprando RL, et al. (1996). Effect of intratesticular injection of sodium fluoride on spermatogenesis. Food and Chemical Toxicology 34: 377-84.

Stannard JG, et al. (1991). Fluoride Levels and Fluoride Contamination of Fruit Juices. Journal of Clinical Pediatric Dentistry 16: 38-40.

Stecher P, et al. (1960). The Merck Index of Chemicals and Drugs. Merck & Co., Inc, Rathway NJ. p. 952.

Steelink C. (1992). Fluoridation controversy. Chemical & Engineering News (Letter). July 27: 2-3.

Strunecka A, Patocka J. (1999). Pharmacological and toxicological effects of aluminofluoride complexes. Fluoride 32: 230-242.

Sun ZR, et al. (2000). Effects of high fluoride drinking water on the cerebral functions of mice. Chinese Journal of Epidemiology 19: 262-263.

Susheela AK. (1993). Prevalence of endemic fluorosis with gastrointestinal manifestations in people living in some North-Indian villages. Fluoride 26: 97-104.

Susheela AK, Kumar A. (1991). A study of the effect of high concentrations of fluoride on the reproductive organs of male rabbits, using light and scanning electron microscopy. Journal of Reproductive Fertility 92: 353-60.

Sutton P. (1996). The Greatest Fraud: Fluoridation. Lorne, Australia: Kurunda Pty, Ltd.

Sutton P. (1960) Fluoridation: Errors and Omissions in Experimental Trials. Melbourne University Press. Second Edition.

Sutton, P. (1959). Fluoridation: Errors and Omissions in Experimental Trials. Melbourne University Press. First Edition.

Teotia M, et al. (1998). Endemic chronic fluoride toxicity and dietary calcium deficiency interaction syndromes of metabolic bone disease and deformities in India: year 2000. Indian Journal of Pediatrics 65: 371-81.

Teotia SPS, Teotia M. (1994). Dental caries: a disorder of high fluoride and low dietary calcium interactions (30 years of personal research). Fluoride 27: 59-66.

Teotia SPS, et al. (1976). Symposium on the non-skeletal phase of chronic fluorosis: The Joints. Fluoride 9: 19-24.

Tsutsui T, Suzuki N, Ohmori M, Maizumi H. (1984). Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis in cultured human diploid fibroblasts induced by sodium fluoride. Mutation Research 139:193-8.

Waldbott GL, et al. (1978). Fluoridation: The Great Dilemma. Coronado Press, Inc., Lawrence, Kansas.

Waldbott GL. (1965). A Battle with Titans. Carlton Press, NY.

Wang C, et al. (2000). Treatment Chemicals contribute to Arsenic Levels. Opflow (a journal of the American Water Works Association). October 2000.

Wang Y, et al. (1997). [Changes of coenzyme Q content in brain tissues of rats with fluorosis]. Zhonghua Yu Fang Yi Xue Za Zhi 31: 330-3.

WHO (Online). WHO Oral Health Country/Area Profile Programme. Department of Noncommunicable Diseases Surveillance/Oral Health. WHO Collaborating Centre, Malmö University, Sweden. http://www.whocollab. od.mah.se/euro.html

Williams JE, et al. (1990). Community water fluoride levels, preschool dietary patterns, and the occurrence of fluoride enamel opacities. Journal of Public Health Dentistry 50: 276-81.

Wu DQ, Wu Y. (1995). Micronucleus and sister chromatid exchange frequency in endemic fluorosis. Fluoride 28: 125-127.

Xiang Q, et al. (2003a). Effect of fluoride in drinking water on children's intelligence. Fluoride 36: 84-94.

Xiang Q. (2003b). Blood lead of children in Wamiao-Xinhuai intelligence study. Fluoride 36: 138.

Zakrzewska H, et al. (2002). In vitro influence of sodium fluoride on ram semen quality and enzyme activities. Fluoride 35: 153-160.

Zhai JX, et al. (2003). [Studies on fluoride concentration and cholinesterase activity in rat hippocampus]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21: 102-4.

Zhang Z, et al. (2001). [Effects of selenium on the damage of learning-memory ability of mice induced by fluoride]. Wei Sheng Yan Jiu 30: 144-6.

Zhang Z, et al. (1999). [Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice] [Article in Chinese]. Wei Sheng Yan Jiu 28:210-2.

Zhao XL, Wu JH. (1998). Actions of sodium fluoride on acetylcholinesterase activities in rats. Biomedical and Environmental Sciences 11: 1-6.

Zhao LB, et al (1996). Effect of high-fluoride water supply on children's intelligence. Fluoride 29: 190-192.

Zhao ZL, et al. (1995). The influence of fluoride on the content of testosterone and cholesterol in rat. Fluoride 28: 128-130.

Ziegelbecker R. (1970). A critical review on the fluorine caries problem. Fluoride 3: 71-79.

The 19 studies on the possible association of hip fracture and fluoridated-water.

a) Studies Reporting an Association between fluoridated water (1 ppm fluoride) & hip fracture.

1 a) Cooper C, et al. (1990). Water fluoride concentration and fracture of the proximal femur. Journal of Epidemiology and Community Health 44: 17-19.

1 b) Cooper C, et al. (1991). Water fluoridation and hip fracture. JAMA 266: 513-514 (letter, a reanalysis of data presented in 1990 paper).

2) Danielson C, et al. (1992). Hip fractures and fluoridation in Utah's elderly population. Journal of the American Medical Association 268: 746-748.

3) Hegmann KT, et al. (2000). The Effects of Fluoridation on Degenerative Joint Disease (DJD) and Hip Fractures. Abstract #71, of the 33rd Annual Meeting of the Society For Epidemiological research, June 15-17, 2000. Published in a Supplement of American Journal of Epidemiology P. S18.

4) Jacobsen SJ, et al. (1992). The association between water fluoridation and hip fracture among white women and men aged 65 years and older; a national ecologic study." Annals of Epidemiology 2: 617-626.

5) Jacobsen SJ, et al. (1990). Regional variation in the incidence of hip fracture: US white women aged 65 years and olders. JAMA 264(4): 500-2.

6 a) Jacqmin-Gadda H, et al. (1995). Fluorine concentration in drinking water and fractures in the elderly. JAMA 273: 775-776 (letter).

6 b) Jacqmin-Gadda H, et al. (1998). Risk factors for fractures in the elderly. Epidemiology 9(4): 417-423. (An elaboration of the 1995 study referred to in the JAMA letter).

7) Keller C. (1991) Fluorides in drinking water. Unpublished results. Discussed in Gordon, S.L. and Corbin, S.B,(1992) Summary of Workshop on Drinking Water Fluoride Influence on Hip Fracture on Bone Health. Osteoporosis International 2: 109-117.

8) Kurttio PN, et al. (1999). Exposure to natural fluoride in well water and hip fracture: A cohort analysis in Finland. American Journal of Epidemiology 150(8): 817-824.

9) May DS, Wilson MG. (1992). Hip fractures in relation to water fluoridation: an ecologic analysis. Unpublished data, discussed in Gordon SL, and Corbin SB. (1992). Summary of Workshop on Drinking Water Fluoride Influence on Hip Fracture on Bone Health. Osteoporosis International 2:109-117.

b) Studies reporting an association between water-fluoride levels higher than fluoridated water (4 ppm+) & hip fracture.

Li Y, et al. (2001). Effect of long-term exposure to fluoride in drinking water on risks of bone fractures. Journal of Bone and Mineral Research 16: 932-9.

Sowers M, et al. (1991). A prospective study of bone mineral content and fracture in communities with differential fluoride exposure. American Journal of Epidemiology 133: 649-660.

c) Studies Reporting No Association between water fluoride & hip fracture:

(Note that in 4 of these 8 studies, an association was actually found between fluoride and some form of fracture – e.g. wrist and hip. See notes and quotes below.)

Cauley J. et al. (1995). Effects of fluoridated drinking water on bone mass and fractures: the study of osteoporotic fractures. Journal of Bone and Mineral Research 10: 1076-86.

Feskanich D, et al. (1998). Use of toenail fluoride levels as an indicator for the risk of hip and forearm fractures in women. Epidemiology 9: 412-6.

While this study didn't find an association between water fluoride and hip fracture, it did find an association - albeit non-significant 1.6 (0.8-3.1) - between fluoride exposure and elevated rates of forearm fracture.

Hillier S, et al. (2000). Fluoride in drinking water and risk of hip fracture in the UK: a case control study. The Lancet 335: 265-2690.

Jacobsen SJ, et al. (1993). Hip Fracture Incidence Before and After the Fluoridation of the Public Water Supply, Rochester, Minnesota. American Journal of Public Health 83: 743-745.

Karagas MR, et al. (1996). Patterns of Fracture among the United States Elderly: Geographic and Fluoride Effects. Annals of Epidemiology 6: 209-216.

As with Feskanich (1998) this study didn't find an association between fluoridation & hip fracture, but it did find an association between fluoridation and distal forearm fracture, as well as proximal humerus fracture. "Independent of geographic effects, men in fluoridated areas had modestly higher rates of fractures of the distal forearm and proximal humerus than did men in nonfluoridated areas."

Lehmann R, et al. (1998). Drinking Water Fluoridation: Bone Mineral Density and Hip Fracture Incidence. Bone 22: 273-278.

Phipps KR, et al. (2000). Community water fluoridation, bone mineral density and fractures: prospective study of effects in older women. British Medical Journal 321: 860-4.

As with Feskanich (1998) and Karagas (1996), this study didn't find an association between water fluoride & hip fracture, but it did find an association between water fluoride and other types of fracture - in this case, wrist fracture. "There was a non-significant trend toward an increased risk of wrist fracture."

Suarez-Almazor M, et al. (1993). The fluoridation of drinking water and hip fracture hospitalization rates in two Canadian communities. American Journal of Public Health 83: 689-693.

While the authors of this study conclude there is no association between fluoridation and hip fracture, their own data reveals a statistically significant increase in hip fracture for men living in the fluoridated area. According to the authors, "although a statistically significant increase in the risk of hip fracture was observed among Edmonton men, this increase was relatively small (RR=1.12)."

American Dental Association Agrees Fluoride is Bad

2007-12-17T12:51:00.000-08:00

The American Dental Association, which has for many years been one of fluoride's biggest advocates, alerted its members late last year that parents of infants younger than a year old "should consider using water that has no or low levels of fluoride" when mixing baby formula.

However, while public health agencies in some states, such as Vermont and New Hampshire, immediately issued warnings in the media based on the ADA alert, other states took months to relay the message.

Florida's Department of Health put the message on its website four months after it was issued along with a note that read: "Mixing formula with fluoridated water poses no known health risks."

The ADA was concerned about fluorosis, a condition caused by too much fluoride that damages the enamel of teeth. Some scientists believe that even mild to moderate cases of fluorosis can lead to more significant problems. Studies have associated fluorosis with lower IQ, endocrine system problems, and skeletal damage.

St. Petersburg Times June 4, 2007

Dr. Mercola's Comment:

After more than half a century of denial, the American Dental Association has finally capitulated to the facts and issued warnings on the dangers of fluoride.

Adding fluoride to drinking water (to prevent tooth decay) has been standard practice in many countries for 60 years. But the practice has come under scrutiny, as fluoride has been banned by more and more European countries.

Unfortunately, too much fluoride can lead to fluorosis, a discoloring of the teeth and breakdown of enamel -- itself a result diametrically opposed to the dental health it supposedly is meant to prevent -- and more serious developmental problems such as lower IQ. Excessive use of fluoride also increases the risk of osteoporosis and can damage the nervous system.

Children enrolled in the Women, Infant and Children's Nutrition program (WIC) are particularly at risk, since the WIC program only subsidizes powdered and condensed baby formulas that have to be mixed with water.

If you are unable to breastfeed, please educate yourself on the dangers of fluoride (an industrial waste product from the phosphate fertilizer industry) as well as the health risks of using infant formulas. Instead of mixing already unhealthy formulas with fluoridated water, take the advice from my series, Healthy Alternative to Conventional Infant Formula, which includes recipes for healthy homemade baby formulas.

Recently I posted a video with award-winning author Christopher Bryson, in which he reveals the dangerous deception at the heart of the unnecessary use of this toxic chemical. If you didn't see before, here's your second chance.

Fluoride Toothpaste and alternatives

2007-12-17T12:47:00.000-08:00

Typical toothpaste is regulated as a drug by the FDA because an average tube contains enough fluoride to kill a small child. Most people in the United States have been living under the false assumption that fluoride toothpaste is essential to preventing cavities, when in reality it is a dangerous poison.

Too much fluoride can lead to fluorosis, a discoloring of your teeth and breakdown of enamel -- itself a result diametrically opposed to the dental health it supposedly is meant to prevent -- and more serious developmental problems such as lower IQ. Excessive use of fluoride also increases your risk of osteoporosis and can damage your nervous system, not to mention its links to:

Cancer
Developmental and reproductive toxicity
Endocrine disruption
Organ system toxicity
Neurotoxicity

As the word about the dangers of fluoride gets out -- even the American Dental Association admitted this year that fluoride is bad -- more of you are seeking out natural toothpaste varieties.

Others are seeking natural toothpastes because they’re catching on to the importance of limiting your exposure to as many artificial chemicals as possible. And rest assured that fluoride is not the only skeleton hiding in your typical toothpaste’s closet.

A quick reading of the ingredients in one leading brand of toothpaste reveals:

Triclosan: A preservative and cosmetic biocide that has been linked to endocrine disruption, organ system toxicity, and bioaccumulation

Sodium lauryl sulfate: A cleansing agent linked to cancer and developmental and reproductive toxicity

Tetrasodium pyrophosphate: An oral care agent that animal studies have found impact your brain and nervous system at low doses

Hydrated silica: An anticaking agent that bioaccumulates in people and wildlife

FD&C Blue 1: An artificial coloring linked to cancer

You would think, then, that a natural toothpaste label would be much more, well, natural. Some, in fact, are. But you must be careful to read the label and know what you’re buying. For instance, here are some of the ingredients in a leading non-fluoride natural toothpaste:

Sodium monofluorophosphate: An oral care agent linked to neurotoxicity, developmental and reproductive toxicity, and possibly cancer.

Sodium lauryl sulfate: Same as above.

The bottom line is that personal care products are not regulated, and those that claim to be natural can be far from it.

Look for a simple natural, non-fluoride toothpaste with only familiar ingredients, and skip all of the bells and whistles like “whitening,” “enamel strengthening,” and “multi-action.” If you’re looking for a safe way to make your teeth whiter, you can try this truly natural formula using strawberries and baking soda.

Many people think their non-fluoride toothpaste is healthy. However, it is much more difficult to find toothpaste that doesn't contain Sodium Laurel Sulfate (originally created as an engine degreaser).

Fluoride in your water = Toxic Waste

2007-12-07T13:45:00.000-08:00

How to Market a Toxic Waste

"We would not purposely add arsenic to the water supply. And we would not purposely add lead. But we do add fluoride. The fact is that fluoride is more toxic than lead and just slightly less toxic than arsenic." (1)

These words of Dr. John Yiamouyiannis may come as a shock to you because, if you're like most Americans, you have positive associations with fluoride. You may envision tooth protection, strong bones, and a government that cares about your dental needs. What you've probably never been told is that the fluoride added to drinking water and toothpaste is a crude industrial waste product of the aluminum and fertilizer industries, and a substance toxic enough to be used as rat poison. How is it that Americans have learned to love an environmental hazard? This phenomenon can be attributed to a carefully planned marketing program begun even before Grand Rapids, Michigan, became the first community to officially fluoridate its drinking water in 1945.(2) As a result of this ongoing campaign, nearly two-thirds of the nation has enthusiastically followed Grand Rapids' example. But this push for fluoridation has less to do with a concern for America's health than with industry's penchant to expand at the expense of our nation's well-being.

The first thing you have to understand about fluoride is that it's the problem child of industry. Its toxicity was recognized at the beginning of the Industrial Revolution, when, in the 1850s iron and copper factories discharged it into the air and poisoned plants, animals, and people.(3)

In the early years of the 20th Century, a young dentist named Frederick McKay settled in Colorado Springs, Colorado. There he discovered that as many as 90% of lifetime residents of the town had grotesque brown stains on their teeth, and that the tooth enamel had an irregular surface texture described as "mottled". Locals referred to the familiar condition as Colorado Brown Stain, but no one had a clue as to its cause. Over the next two decades Dr. McKay, later with the help of dental researcher G. V. Black, proved that the cause was something contaminating the water supply. They also speculated that the affected teeth might be somewhat more resistant to decay. (4)

By the 1920's, rapid industrial growth had exacerbated the problems of industrial pollution, and fluoride was one of the biggest problems. Medical writer Joel Griffiths explains that "it was abundantly clear to both industry and government that spectacular U.S. industrial expansion -- and the economic and military power and vast profits it promised -- would necessitate releasing millions of tons of waste fluoride into the environment."(5) Their biggest fear was that "if serious injury to people were established, lawsuits alone could prove devastating to companies, while public outcry could force industry-wide government regulations, billions in pollution-control costs, and even mandatory changes in high-fluoride raw materials and profitable technologies."(6)

In 1931, by means of photo-spectrographic analysis of McKay and Black's water samples conducted at the laboratories at the Aluminum Company of America (ALCOA), it was confirmed that the cause of the mottled teeth was fluoride in the water supply. ALCOA took a proprietary interest in this issue, since fluoride is a major waste product of aluminum production. The company wanted to know how much fluoride exposure people could tolerate without getting mottled, discolored teeth. Or, more specifically, how much fluoride could ALCOA release into the nation's earth, water, and air without the public realizing that the company was polluting the environment with a powerful toxin?(7)

That question was to be addressed later that same year, when H. Trendley Dean was sent to study water sources in 345 Texas communities. Dean, a former dental surgeon for the US Public Health Service, was then head of the Dental Hygiene Unit of the National Institute of Health. (Dean's overseer and mentor at the USPHS had been Treasury Secretary Andrew W. Mellon, a founder and major stockholder of ALCOA.) Based on his own research, Dean claimed that "fluoride levels of up to 1.0 ppm in drinking water did not cause mottled enamel; if the fluoride exceeded this level, however, fluorosis would occur."(8)

Now Dean remembered McKay and Black's claims that fluorosis victims mottled, discolored teeth were especially resistant decay. He came up with the notion that fluoride added to the water supply at the magic threshold dosage of 1 ppm would prevent tooth decay, while avoiding damage to bones and teeth.(9) He recommended further studies to determine whether his hypothesis was true.

Griffiths continues: "Back at the Mellon Institute, ALCOA's Pittsburgh industrial research lab, this news was galvanic. There, biochemist Gerald J. Cox immediately fluoridated some lab rats in a study and concluded that fluoride reduced cavities and that: "The case should be regarded as proved." In a historic moment in 1939, the first public proposal that the U.S. should fluoridate its water supplies was made not by a doctor, or dentist, but by Cox, an industry scientist working for a company threatened by fluoride damage claims and burdened by the odious expense of disposing of tons of toxic industrial waste. Cox began touring the country, stumping for fluoridation.(10)

Dean would go on to carve out a nice career for himself as the "father" of public water fluoridation. He became the first dental scientist at the National Institute of Health, advancing to director of the dental research section in 1945. After World War II, he directed epidemiological studies for the Army in Germany. When Congress established the National Institute of Dental Research (NIDR) in 1948, Dean was appointed its director, a position he held until retiring in 1953.(11) In his post at the NIDR, he was to oversee the first clinical trial of fluoridation in an American city, Grand Rapids Michigan.(12)

With those impressive credentials, wouldn't you think a man of science like Dean could be trusted? Think again. The truth is that Dean's great discovery was based on wishful thinking and some very shaky science, as documented by healthy advocate Andreas Schuld(13). Dean's findings did not stand up to scientific scrutiny at all. An independent study of his results revealed that he had engaged in "selective use of data," employing figures from 21 cities that confirmed his findings, and ignoring those from 272 other localities that didn't. (14) In a 1955 court case challenging fluoridation, Dean admitted under oath that his published conclusions were wrong.(15) In hearings conducted by the AMA in 1957, he was forced to admit that dental fluorosis, the first sign of fluoride overdose, could be caused by water fluoridated at 1.0 ppm.(16) But these admissions were not widely publicized, and they were never acknowledged by the USPHS, the American Dental Association, or the other governmental bodies responsible for foisting fluoride on the public. They continued to play the classic denial game: "act like nothing's wrong." And they are still doing it to this very day.

At first, industry could dispose of fluoride legally only in small amounts by selling it to insecticide and rat poison manufacturers. (17) But Dean's "discovery," paved the way for a commercial outlet for the toxin. Griffiths writes that this was not a scientific breakthrough, but rather part of a "public disinformation campaign" by the aluminum industry "to convince the public that fluoride was safe and good," Industry's need prompted Alcoa-funded scientist Gerald J. Cox to announce that "The present trend toward complete removal of fluoride from water may need some reversal."(18) Griffiths writes:

"The big news in Cox's announcement was that this 'apparently worthless by-product' had not only been proved safe (in low doses), but actually beneficial; it might reduce cavities in children. A proposal was in the air to add fluoride to the entire nation's drinking water. While the dose to each individual would be low, 'fluoridation' on a national scale would require the annual addition of hundreds of thousands of tons of fluoride to the country's drinking water.

"Government and industry - especially Alcoa - strongly supported intentional water fluoridation...[it] made possible a master public relations stroke - one that could keep scientists and the public off fluoride's case for years to come. If the leaders of dentistry, medicine, and public health could be persuaded to endorse fluoride in the public's drinking water, proclaiming to the nation that there was a 'wide margin of safety,' how were they going to turn around later and say industry's fluoride pollution was dangerous?

"As for the public, if fluoride could be introduced as a health enhancing substance that should be added to the environment for the children's sake, those opposing it would look like quacks and lunatics....

"Back at the Mellon Institute, Alcoa's Pittsburgh Industrial research lab, this news was galvanic. Alcoa-sponsored biochemist Gerald J. Cox immediately fluoridated some lab rats in a study and concluded that fluoride reduced cavities and that 'The case should be regarded as proved.' In a historic moment in 1939, the first public proposal that the U.S. should fluoridate its water supplies was made - not by a doctor, or dentist, but by Cox, an industry scientist working for a company threatened by fluoride damage claims."(19)

Once the plan was put into action, industry was buoyant. They had finally found the channel for fluoride that they were looking for, and they were even cheered on by dentists, government agencies, and the public. Chemical Week, a publication for the chemical industry, described the tenor of the times: "All over the country, slide rules are getting warm as waterworks engineers figure the cost of adding fluoride to their water supplies." They are riding a trend urged upon them, by the U.S. Public Health Service, the American Dental Association, the State Dental Health Directors, various state and local health bodies, and vocal women's clubs from coast to coast. It adds up to a nice piece of business on all sides and many firms are cheering the PHS and similar groups as they plump for increasing adoption of fluoridation." (20)

Such overwhelming acceptance allowed government and industry to proceed hastily, albeit irresponsibly. The Grand Rapids experiment was supposed to take 15 years, during which time health benefits and hazards were to be studied. In 1946, however, just one year into the experiment, six more U.S. cities adopted the process. By 1947, 87 more communities were treated; popular demand was the official reason for this unscientific haste.

The general public and its leaders did support the cause, but only after a massive government public relations campaign spearheaded by Edward L. Bernays, a nephew of Sigmund Freud. Bernays, a public relations pioneer who has been called "the original spin doctor,"(21) was a masterful PR strategist. As a result of his influence, Griffiths writes, "Almost overnight...the popular image of fluoride -- which at the time was being widely sold as rat and bug poison -- became that of a beneficial provider of gleaming smiles, absolutely safe, and good for children, bestowed by a benevolent paternal government. Its opponents were permanently engraved on the public mind as crackpots and right-wing loonies."(22)

Griffiths explains that while opposition to fluoridation is usually associated with right-wingers, this picture is not totally accurate. He provides an interesting historical perspective on the anti-fluoridation stance:

"Fluoridation attracted opponents from every point on the continuum of politics and sanity. The prospect of the government mass-medicating the water supplies with a well-known rat poison to prevent a nonlethal disease flipped the switches of delusionals across the country - as well as generating concern among responsible scientists, doctors, and citizens.

"Moreover, by a fortuitous twist of circumstances, fluoride's natural opponents on the left were alienated from the rest of the opposition. Oscar Ewing, a Federal Security Agency administrator, was a Truman "fair dealer" who pushed many progressive programs such as nationalized medicine. Fluoridation was lumped with his proposals. Inevitably, it was attacked by conservatives as a manifestation of "creeping socialism," while the left rallied to its support. Later during the McCarthy era, the left was further alienated from the opposition when extreme right-wing groups, including the John Birch Society and the Ku Klux Klan, raved that fluoridation was a plot by the Soviet Union and/or communists in the government to poison America's brain cells.

"It was a simple task for promoters, under the guidance of the 'original spin doctor,' to paint all opponents as deranged - and they played this angle to the hilt....

"Actually, many of the strongest opponents originally started out as proponents, but changed their minds after a close look at the evidence. And many opponents came to view fluoridation not as a communist plot, but simply as a capitalist-style con job of epic proportions. Some could be termed early environmentalists, such as the physicians George L. Waldbott and Frederick B. Exner, who first documented government-industry complicity in hiding the hazards of fluoride pollution from the public. Waldbott and Exner risked their careers in a clash with fluoride defenders, only to see their cause buried in toothpaste ads." (23)

By 1950, fluoridation's image was a sterling one, and there was not much science could do at this point. The Public Health Service was fluoridation's main source of funding as well as its promoter, and therefore caught in a fundamental conflict of interest.(24) If fluoridation were found to be unsafe and ineffective, and laws were repealed, the organization feared a loss of face, since scientists, politicians, dental groups, and physicians unanimously supported it.(25) For this reason, studies concerning its effects were not undertaken. The Oakland Tribune noted this when it stated that "public health officials have often suppressed scientific doubts" about fluoridation. (26) Waldbott sums up the situation when he says that from the beginning, the controversy over fluoridating water supplies was "a political, not a scientific health issue."(27)

The marketing of fluoride continues. In a 1983 letter from the Environmental Protection Agency, then Deputy Assistant Administrator for Water, Rebecca Hammer, writes that the EPA "regards [fluoridation] as an ideal environmental solution to a long-standing problem. By recovering by-product fluosilicic acid from fertilizer manufacturing, water and air pollution are minimized and water utilities have a low-cost source of fluoride available to them."(28) More recently, a 1992 policy statement from the Department of Health and Human Services says, "A recent comprehensive PHS review of the benefits and potential health risks of fluoride has concluded that the practice of fluoridating community water supplies is safe and effective."(29)

Today, nearly 250 million people worldwide drink fluoridated water, including about 130 million Americans in 9600 communities. Out of the 50 largest cities in the US, 41 have fluoridated water.(30)

To help celebrate fluoride's widespread use, the media recently reported on the 50th anniversary of fluoridation in Grand Rapids. Newspaper articles titled "Fluoridation: a shining public health success"(31) and "After 50 years, fluoride still works with a smile"(32) painted glowing pictures of the practice. Had investigators looked more closely, though, they might have learned that children in Muskegon, Michigan, an unfluoridated "control" city, had equal drops in dental decay. They might also have learned of the other studies that dispute the supposed wonders of fluoride.

The Fluoride Myth Doesn't Hold Water

The big hope for fluoride was its ability to immunize children's developing teeth against cavities. Rates of dental caries were supposed to plummet in areas where water was treated. Yet decades of experience and worldwide research have contradicted this expectation numerous times. Here are just a few examples:

* In British Columbia, only 11% of the population drinks fluoridated water, as opposed to 40-70% in other Canadian regions. Yet British Columbia has the lowest rate of tooth decay in Canada. In addition, the lowest rates of dental caries within the province are found in areas that do not have their water supplies fluoridated.(33)

* According to a Sierra Club study, people in unfluoridated developing nations have fewer dental caries than those living in industrialized nations. As a result, they conclude that "fluoride is not essential to dental health."(34)

* In 1986-87, the largest study on fluoridation and tooth decay ever was performed. The subjects were 39,000 school children between 5 and 17 living in 84 areas around the country. A third of the places were fluoridated, a third were partially fluoridated, and a third were not. Results indicate no statistically significant differences in dental decay between fluoridated and unfluoridated cities.(35) The benefit to fluoridated communities, if there is any, amounts to 0.6 fewer decayed tooth surfaces per child, which is less than one percent of the tooth surfaces in a child's mouth.(36)

* A World Health Organization survey reports a decline of dental decay in western Europe, which is 98% unfluoridated. They state that western Europe's declining dental decay rates are equal to and sometimes better than those in the U.S.(37)

* A 1992 University of Arizona study yielded surprising results when they found that "the more fluoride a child drinks, the more cavities appear in the teeth."(38)

* Although all Native American reservations are fluoridated, children living there have much higher incidences of dental decay and other oral health problems than do children living in other U.S. communities.(39)

* A 1999 study of water fluoridation in Italy shows that parents' socieconomic status, area of residence, and children's sweets consumption are more significant predictors of dental caries than fluoride consumption. The authors conclude that universal fluoridation is an inadequate approach and the decision to fluoridate or defluoridate water requires careful epidemiological consideration.(40)

* A 2001 article in the Journal of the American Dental Association admits that the fluoride that is swallowed and incorporated into teeth is "insufficient to have a measurable effect" on reducing cavities.(41) This is a stunning admission from the ADA, historically one of the principal supporters and defenders of water fluoridation.

* A follow-up of a study of the town of Kuopio, Finland six years after fluoridation was discontinued found no increase in dental caries. The authors conclude that fluoridation was unnecessary to begin with.(42)

* A study comparing prevalence and incidence of caries in 2,994 life-long residents of British Columbia, Canada, in grades 5, 6, 11, 12, found that caries incidence was not different between the still-fluoridating and fluoridation-ended communities.(43)

* In 1997, following the cessation of drinking water fluoridation in La Salud, Cuba, caries prevalence remained at a low level for the 6- to 9-year-olds and appeared to decrease for the 10/11-year-olds. In the 12/13-year-olds, there was a significant decrease while the percentage of caries-free children of this age group had increased from 4.8 (1973) and 33.3 (1982) up to 55.2%.(44)

* A 1998 study conducted in New Zealand found that "when the timing of various forms of fluoride supplementation is correlated with the decline in caries, the decline continues beyond the time of maximum population coverage with fluoridated water and fluoridated toothpaste." The authors call for a "reassessment of the fluoride effect."(45)

* In contrast to the anticipated increase in dental caries following the cessation of water fluoridation in the German cities Chemnitz (formerly Karl-Marx-Stadt) and Plauen, a significant fall in caries prevalence was observed. This trend corresponded to the national caries decline and appeared to be a new population-wide phenomenon.(46)

A 1999 New York State Department of Health study of 3,500 7-14-year-olds shows that children in fluoridated Newburgh, New York, have no less tooth decay but significantly more dental fluorosis than children from Kingston, New York, which has never been fluoridated. Since 1945, children of the two towns have been examined periodically in order to demonstrate that fluoridation reduces tooth decay. "This new research shows the experiment has failed," the report concludes.(47)

In light of all the evidence, fluoride proponents now make more modest claims. For example, in 1988, the ADA professed that a 40- to 60% cavity reduction could be achieved with the help of fluoride. Now they claim an 18- to 25% reduction. Other promoters mention a 12% decline in tooth decay.

And other former supporters are even beginning to question the need for fluoridation altogether. In 1990, a National Institute for Dental Research report stated that "it is likely that if caries in children remain at low levels or decline further, the necessity of continuing the current variety and extent of fluoride-based prevention programs will be questioned."(48) This is a startling claim coming from the very same governmental organization that spearheaded the drive for compulsory water fluoridation.

A 1999 review of literature conducted by Dr. Hardy Limeback, a long-time advocate of water fluoridation in Canada, indicates that the topical effect of fluoride is its primary mechanism for the prevention of dental caries. Swallowing fluoridated water is ineffective and unnecessary. Limeback concludes that everyone working in the dental health field must examine more closely the risks and benefits of fluoride in all its delivery forms.(49) According to Dr. Limeback, head of preventive dentistry at the University of Toronto, 'Dental decay rates in North America are so low that water fluoridation provides little to no benefit whatsoever these days. In fact, studies show that when you turn the water fluoridation taps off and look for dental decay rates, they don't move whatsoever. There is no increase in dental decay when you stop fluoridating.(50) Limeback adds that what you do see is an increase in unsightly dental fluorosis.(51)51 Today fluorosis occurs on two or more teeth in 30% of children in areas where the water is fluoridated, and not all in its mildest form.(52)

In a letter published in 1999,(53) dentist and public health official Dr. John Colquhoun, formerly one of New Zealand's most prominent pro-fluoridation advocates and educators, explains how over the course of years he came to recognize that there was no benefit in water fluoridation, and that children's dental health is slightly better in nonfluoridated areas than in fluoridated ones.

Most government agencies, however, continue to ignore the scientific evidence and to market fluoridation by making fictional claims about its benefits and pushing for its expansion. For instance, according to the U.S. Department of Health and Human Services, "National surveys of oral health dating back several decades document continuing decreases in tooth decay in children, adults and senior citizens. Nevertheless, there are parts of the country and particular populations that remain without protection. For these reasons, the USPHS...has set a national goal for the year 2000 that 75% of persons served by community water systems will have access to optimally fluoridated drinking water; currently this figure is just about 60%. The year 2000 target goal is both desirable and yet challenging, based on past progress and continuing evidence of effectiveness and safety of this public health measure."(54)

This statement is flawed on several accounts. First, as we've seen, research does not support the effectiveness of fluoridation for preventing tooth disease. Second, purported benefits are supposedly for children, not adults and senior citizens. At about age 13, any advantage fluoridation might offer comes to an end, and less than 1% of the fluoridated water supply reaches this population.(55) And third, fluoridation has never been proven safe. On the contrary, numerous studies directly link fluoridation to disease, including skeletal fluorosis, dental fluorosis, thyroid disorders, brain and kidney damage, Alzheimer's disease, lead poisoning, and several rare forms of cancer. This alone should force us to reconsider its use.

Biological Safety Concerns

Only a small margin separates supposedly beneficial fluoride levels from amounts that are known to cause adverse effects. Dr. James Patrick, a former antibiotics research scientist at the National Institutes of Health, describes the predicament:

"[There is] a very low margin of safety involved in fluoridating water. A concentration of about 1 ppm is recommended. ...in several countries, severe fluorosis has been documented from water supplies containing only 2 or 3 ppm. In the development of drugs... we generally insist on a therapeutic index (margin of safety) of the order of 100; a therapeutic index of 2 or 3 is totally unacceptable, yet that is what has been proposed for public water supplies."(56)

Other countries argue that even 1 ppm is not a safe concentration. Canadian studies, for example, imply that children under three should have no fluoride whatsoever. The Journal of the Canadian Dental Association states that "Fluoride supplements should not be recommended for children less than 3 years old." (57) Since these supplements contain the same amount of fluoride as water does, they are basically saying that children under the age of three shouldn't be drinking fluoridated water at all, under any circumstances. Japan has reduced the amount of fluoride in their drinking water to one-eighth of what is recommended in the U.S. Instead of 1 milligram per liter, they use less than 15 hundredths of a milligram per liter as the upper limit allowed.(58)

The 1 ppm dosage recommendation for water fluoridation has a checkered past, and its present is even more so. As we have seen, the first mention of this "magic" number was made by Dr. Trendley Dean, who jiggled his results to reach the conclusion that "fluoride levels of up to 1.0 ppm in drinking water did not cause mottled enamel; if the fluoride exceeded this level, however, fluorosis would occur."(59)

But the adoption of this dosage for water fluoridation was not Dean's brainchild. It was set in 1953 by Dr. Harold C. Hodge, Ph.D., then chairman of the US National Academy of Sciences committee on toxicology. Unfortunately, Dr. Hodge made a serious miscalculation in his estimate of the safe dosage level for fluoride. His figures err by a factor of 2.25, which means that they understate the toxicity of fluoride considerably. The story of this potentially fatal miscalculation is told in a document from the UK National Pure Water Association:

It is important when any new drug is marketed that the dose at which it is toxic is determined. There is then a margin allowed for safety (usually a factor of 100) and a maximum dose is published. In 1953 the National Academy of Sciences published their estimate of the quantity of fluoride which produces the condition known as crippling skeletal fluorosis. The calculation was done by a famous toxicologist, Harold C. Hodge, Ph.D., who was chairman of the US National Academy of Sciences (NAS) committee on toxicology.

To arrive at his figures, Hodge cited a classic study of the effects of fluoride among cryolite workers by a European researcher, Kaj Roholm, and published in 1937.(60) Roholm's dosage figures were presented in milligrams of fluoride per kilogram of body weight. In his study, Roholm showed that at levels of 0.2 to 0.35mg/kg some workers developed crippling skeletal fluorosis in a very short time. The first stage of the disease appeared, in general, after 2 1Ž2 years; Stage two was reached by 4 1Ž2 years; and crippling skeletal fluorosis appeared after 11 years.

Hodge wanted to apply Roholm's figures to a typical range of body weights in order to set a maximum intake level in milligrams per day. But Hodge was American and used to dealing in pounds rather than kilograms. By using a range of body weights from 100 to 229 pounds, he multiplied the 0.2 mg figure by 100 pounds, giving a figure of 20 mg/day; and 0.35 mg by 229 pounds yielded 80 mg/day. Thus the amounts of fluoride which would cause crippling skeletal fluorosis, he said, were 20mg to 80mg per day. And rather than quote Roholm's eleven year figure for crippling fluorosis, he gave a range of 10 to 20 years. These are the figures that appear in the American Dental Association's pamphlet, Fluoridation Facts, and on which many other articles are based, even today.

But Hodge made a simple but significant error. Roholm's figures were not for pounds. They were milligram per kilogram figures. Unfortunately, Hodge was the expert and no-one, apparently, checked his figures. This error, which gave a false safety margin more than double what it should have been went unnoticed for many years until anti-fluoride campaigner, Darlene Sherrell tried to duplicate Hodge's arithmetic and couldn't make it add up. She worked out that Hodge had made an error when he neglected to convert pounds to kilograms.

Correcting for this error, Sherrell reduced the amount of fluoride needed to be crippling to 10 to 25 milligrams per day, for 10 to 20 years.

But fluorides accumulate throughout our lives so a higher intake will have the same effect in a shorter time, and smaller doses will have the same effect in a longer time. If we apply Roholm's dosage figures to a lifetime of 55 to 96 years, just 1 mg per day (the amount in one litre of water) for each 55 pounds of body weight could be a crippling dosage.

The NAS Admits It Was Wrong

In 1989 Sherrell wrote to the NAS and asked on what they based their 20 to 80 mg/day figures. Two years passed before the Academy told her that they had identified Hodge's interpretation of Roholm as the data source.

Four years later the error was finally corrected by the National Research Council's Board on Environmental Studies and Toxicology in their 1993 publication, Health Effects of Ingested Fluoride where they changed the figure from 20-80mg/day to 10-20mg/day (61).

As it happens, Hodge had written a chapter in a book released in 1979 entitled Continuing Evaluation of the Use of Fluorides. In it Hodge had corrected his previously published figures. But nobody seemed to notice. In 1991, when the US Department of Health and Human Services published their Review of Fluoride: Benefits and Risks, they continued to use figures of 20-80 mg/day as the 'crippling daily dose of fluoride'. As, indeed does the current RDA and Dietary Reference Intakes published by the Institute of Medicine in 1997.

Myths are Very Hard to Dislodge

We can get a good idea of how much fluoride is safe by working with Roholm's figures. You will remember that after the figures had been corrected, the amount needed to cause crippling fluorosis in a 100 to 229 lb person was reckoned to be 10 to 20 mg per day for 10 to 20 years. Since fluorides accumulate in a linear fashion, the crippling dosage of 10 mg per day for 10 years is the same as 5 mg per day for 20 years, and so on. If we extrapolate this to a normal lifetime with fluoridated water this is the same as 2.5 to 5 mg per day for 40 to 80 years. But we should note that, for persons with kidney disease, the risk is greater because less fluoride will be eliminated by their malfunctioning kidneys.

It is also important to note that these figures are for crippling fluorosis, the last stage. It will take only four years at 10 mg/day, or sixteen years at 2.5 mg per day before a 100 pound individual can expect to experience phase 2, musculo-skeletal fluorosis, with chronic joint pain and arthritic symptoms - with or without osteoporosis. That is the amount of fluoride found in just 2 1Ž2 litres of water. And that's without counting the extra that today is inevitably found in foods, toothpaste, et cetera

From this it is clear that the only safe limit for fluoride is NONE

Even supposing that low concentrations are safe, there is no way to control how much fluoride different people consume, as some take in a lot more than others. For example, laborers, athletes, diabetics, and those living in hot or dry regions can all be expected to drink more water, and therefore more fluoride (in fluoridated areas) than others.(62) Due to such wide variations in water consumption, it is impossible to scientifically control what dosage of fluoride a person receives via the water supply.(63)

In "50 Reasons to Oppose Fluoridation,"(64)64 Paul Connett, Ph.D., Professor of Chemistry at St. Lawrence University (NY) states that the supposedly safe fluoride levels in our water may pose a particular danger for any of the millions of people who suffer from thyroid disorders. He explains:

Earlier in the 20th century, fluoride was prescribed by a number of European doctors to reduce the activity of the thyroid gland for those suffering from hyperthyroidism (over active thyroid) (Merck Index, 1960, p. 952; Waldbott, et al., 1978, p. 163). With water fluoridation, we are forcing people to drink a thyroid-depressing medication which could serve to promote higher levels of hypothyroidism (underactive thyroid) in the population, and all the subsequent problems related to this disorder. Such problems include depression, fatigue, weight gain, muscle and joint pains, increased cholesterol levels, and heart disease.

It bears noting that according to the Department of Health and Human Services (1991) fluoride exposure in fluoridated communities is estimated to range from 1.58 to 6.6 mg/day, which is a range that actually overlaps the dose (2.3 - 4.5 mg/day) shown to decrease the functioning of the human thyroid.(65)65 This is a remarkable fact, and certainly deserves greater attention considering the rampant and increasing problem of hypothyroidism in the United States. (In 1999, the second most prescribed drug of the year was Synthroid, which is a hormone replacement drug used to treat an underactive thyroid." More than twenty million people in the U.S. receive treatment for thyroid problems and many others are thought to go undiagnosed. (66)

And by the way, 90% of the fluoride added to our drinking water is no longer the sodium fluoride at all. Today's fluoride is industrial waste that is complexed with silica or sodium. "Fluoride complexed with silica or sodium is readily ionized to free fluoride ions that are quickly absorbed in the gastrointestinal tract, whereas, when chemically bound to calcium, less of it ionizes and less is absorbed. Calcium inhibits fluoride absorption and is, in fact, the treatment of choice for fluoride ingestion overdoses."(67)

Another concern is that fluoride is not found only in drinking water; it is everywhere. Fluoride is found in foods that are processed with it, which, in the United States, include nearly all bottled drinks and canned foods.(68)68 Researchers writing in The Journal of Clinical Pediatric Dentistry have found that fruit juices, in particular, contain significant amounts of fluoride. In a recent study, a variety of popular juices and juice blends were analyzed and it was discovered that 42% of the samples examined had more than l ppm of fluoride, with some brands of grape juice containing much higher levels - up to 6.8 ppm! The authors cite the common practice of using fluoride-containing insecticide in growing grapes as a factor in these high levels, and they suggest that the fluoride content of beverages be printed on their labels, as is other nutritional information.(69) Considering how much juice some children ingest, and the fact that youngsters often insist on particular brands that they consume day after day, labeling seems like a prudent idea.

Clean water activist Jeff Green points out that fluoride is "in Wheaties at 10 ppm, 10 times the amount that you find in water. It's in Post Grape Nuts and Shredded Wheat and Fruit Loops. These are items that people are eating all the time without realizing that it has fluoride in it. Because it's a pesticide residue that's allowed to be on produce now it's taken a big jump and the EPA has allowed it to be at really high levels, 180 ppm on a head of lettuce, 55 ppm on raisins. I mean no child is going to wash all that off."(70)

Prepared baby foods are a problem, too. A 1997 article in the Journal of the American Dental Association(71) warns that some baby foods contain such high levels of fluoride that babies who eat the food risk dental fluorosis. "Any infants who regularly eat more than a couple of ounces of infant foods containing high-fluoride-content chicken would be at elevated fluorosis risk," the authors conclude.(72) Infants who eat large quantities of dry infant cereals reconstituted with fluoridated water could ingest substantial quantities of fluoride from this source, this study shows. "Children should also be monitored to make sure that they do not ingest too much fluoride from other sources such as fluoride dentifrice, dietary fluoride supplements or fluoridated water...."(73)

Fluoride exposure during infancy can be expect to increase risk of fluoride-related illness, since a recent study shows that the first year of life is the most critical period for fluoride exposure. Children exposed during the first year of life, and to a lesser extent in the second year, are far more likely to develop fluorosis than those whose exposure begins later. The early mineralizing teeth-the central incisors and first molars-are most likely to be affected.(74)

This is confirmed by a recent study of fluorosis risk. "There is substantial evidence that fluoridated water, fluoride supplements, infant formulas, and fluoride toothpastes are risk factors for fluorosis," alone and together, reports Ohio State University researcher Dr. Ana Karina Mascarenhas.(75)

A recent study of fluoridated and non-fluoridated communities in Brazil proved that fluoride toothpaste contributes to fluorosis. In the study, children who started using fluoride before the age of three were 4.43 times more likely to have dental fluorosis than those who started using it after the age of three.(76)

Dr. Connett observes that "the level of fluoride put into water (1 ppm) is 100 times higher than normally found in mothers' milk (0.01 ppm) (77) There are no benefits, only risks, for infants ingesting this heightened level of fluoride at such an early age (this is an age where susceptibility to environmental toxins is particularly high). "

Fluorosis get worse as a child approaches puberty, according to study done in Norway. The study showed a significant increase in the severity of fluorosis with increasing age in a high fluoride community, whereas no change in severity with age was observed in a low fluoride community. Fluorosis resulting from high fluoride content of drinking water increases between the ages of ten and fourteen.(78)

But beyond this is the larger issue that this study brings up: Is it wise to subject children and others who are heavy juice drinkers to additional fluoride in their water?

Here's a little-publicized reality: Cooking can greatly increase a food's fluoride content. Peas, for example, contain 12 micrograms of fluoride when raw and 1500 micrograms after they are cooked in fluoridated water, which is a tremendous difference. Also, we should keep in mind that fluoride is an ingredient in pharmaceuticals, aerosols, insecticides, and pesticides.

And of course, toothpastes. It's interesting to note that in the 1950s, fluoridated toothpastes were required to carry warnings on their labels saying that they were not to be used in areas where water was already fluoridated. Crest toothpaste went so far as to write: "Caution: Children under 6 should not use Crest." These regulations were dropped in 1958, although no new research was available to prove that the overdose hazard no longer existed.Today, common fluoride levels in toothpaste are 1000 ppm. Research chemist Woodfun Ligon notes that swallowing a small amount adds substantially to fluoride intake. Dentists say that children commonly ingest up to 0.5 mg of fluoride a day from toothpaste.(79)

Dr. Hardy Limeback cites studies conducted by the toothpaste manufacturers showing that children under the age of six typically swallow as much as 60 percent of the toothpaste that goes into their mouths. "The warning labels, in my personal opinion, are there to get them off the hook in the next ten years. People who have been exposed to too much fluoride ingestion before the tubes were labeled have a case against the toothpaste companies. They weren't told that a lifetime of fluoride ingestion may be harmful."(80)

This inevitably raises another issue: How safe is all this fluoride? According to scientists and informed doctors, such as Dr. John Lee, it is not safe at all. Dr. Lee first took an anti-fluoridation stance back in 1972, when as chairman of an environmental health committee for a local medical society, he was asked to state their position on the subject. He stated that after investigating the references given by both pro- and anti-fluoridationists, the group discovered three important things:

"One, the claims of benefit of fluoride, the 60% reduction of cavities, was not established by any of these studies. Two, we found that the investigations into the toxic side effects of fluoride have not been done in any way that was acceptable. And three, we discovered that the estimate of the amount of fluoride in the food chain, in the total daily fluoride intake, had been measured in 1943, and not since then. By adding the amount of fluoride that we now have in the food chain, which comes from food processing with fluoridated water, plus all the fluoridated toothpaste that was not present in 1943, we found that the daily intake of fluoride was far in excess of what was considered optimal."(81)

What happens when fluoride intake exceeds the optimal? The inescapable fact is that this substance has been associated with severe health problems, ranging from skeletal and dental fluorosis to bone fractures, to fluoride poisoning, and even to cancer.

Dental Fluorosis

According to a 1989 National Institute for Dental Research study, 1-2% of children living in areas fluoridated at 1 ppm develop dental fluorosis, that is, permanently stained, brown mottled teeth. Up to 23% of children living in areas naturally fluoridated at 4 ppm develop severe dental fluorosis. Other research gives higher figures. The publication Health Effects of Ingested Fluoride, put out by the National Academy of Sciences, reports that in areas with optimally fluoridated water (1 ppm, either natural or added), dental fluorosis levels in recent years ranged from 8 to 51%. Recently, a prevalence of slightly over 80% was reported in children 12-14 years old in Augusta, Georgia.(82)

Fluoride is a noteworthy chemical additive in that it's officially acknowledged benefit and damage levels are about the same. Writing in The Progressive, science journalist Daniel Grossman elucidates this point: "Though many beneficial chemicals are dangerous when consumed at excessive levels, fluoride is unique because the amount that dentists recommend to prevent cavities is about the same as the amount that causes dental fluorosis."(83) Although the American Dental Association and the government consider dental fluorosis only a cosmetic problem, the American Journal of Public Health says that "...brittleness of moderately and severely mottled teeth may be associated with elevated caries levels."(84) In other words, in these cases the fluoride is causing the exact problem that it's suppos ed to prevent. Yiamouyiannis adds, "In highly naturally-fluoridated areas, the teeth actually crumble as a result. These are the first visible symptoms of fluoride poisoning."(85)

Also, when considering dental fluorosis, there are factors beyond the physical that you can't ignore - the negative psychological effects of having moderately to severely mottled teeth. These were recognized in a 1984 National Institute of Mental Health panel that looked into this problem.(86)

A telling trend is that TV commercials for toothpaste, and toothpaste tubes themselves, are now downplaying fluoride content as a virtue. This was noted in an article in the Sarasota/Florida ECO Report,(87) whose author, George Glasser, feels that manufacturers are distancing themselves from the additive because of fears of lawsuits. The climate is ripe for these, and Glasser points out that such a class action suit has already been filed in England against the manufacturers of fluoride-containing products on behalf of children suffering from dental fluorosis.

Still, certain segments of industry have yet to get the message. A recent newspaper ad campaign promotes Dannon's "Fluoride to Go" spring water "for kids who can't sit still."(88) Supplied in convenient kid-sized bottles with the pop-up "athletic" cap kids adore, the product perpetuates fluoride's false promise of better dental health for the new generation of kids for whom bottled water is more desirable than soda pop. The irony is that the shift from pop to water is one thing that does impact children's dental health significantly. Fluoride is totally out of place in this scenario. It makes one wonder how much fluoride might be in other brands of bottled water, including Evian and Volvic, which are owned by Dannon's parent company.

Skeletal Fluorosis

When fluoride is ingested, approximately 93% of it is absorbed into the bloodstream. A good part of the material is excreted, but the rest is deposited in the bones and teeth,(89) and is capable of causing a crippling skeletal fluorosis. This is a condition that can damage the musculoskeletal and nervous systems and result in muscle wasting, limited joint motion, spine deformities, and calcification of the ligaments, as well as neurological deficits.(90)

Large numbers of people in Japan, China, India, the Middle East, and Africa have been diagnosed with skeletal fluorosis from drinking naturally fluoridated water. In India alone, nearly a million people suffer from the affliction.(91) While only a dozen cases of skeletal fluorosis have been reported in the United States, Chemical and Engineering News states that "critics of the EPA standard speculate that there probably have been many more cases of fluorosis - even crippling fluorosis - than the few reported in the literature because most doctors in the U.S. have not studied the disease and do not know how to diagnose it."(92) Because some symptoms of skeletal fluorosis mimic those of arthritis, the first two clinical phases of fluorosis can be easily misdiagnosed.(93) According to Dr. Paul Connett, the causes of most forms of osteoarthritis are unknown. It is not implausible that the high prevalence of arthritis in America (42 million Americans have it) may be related to our high levels of fluoride intake.(94)

Dr. Hardy Limeback says, " We're quite concerned that fluoride accumulates through a lifetime of water fluoridation and causes the bone to become more brittle. We've started a study, and we're close to publishing it, that shows that people who have been exposed to just 20 to 30 years of water fluoridation have twice the amount of fluoride in their bones. Now there are all kinds of epidemiological studies to show that people who live in fluoridated areas have a higher risk for hip and other kinds of fractures, such as forearm fractures when they fall down. So this is quite a concern. I personally don't think that we need to be ingesting fluoride to protect our kids' teeth because they're already protected at a maximum. The rest of us are swallowing all this fluoride from the drinking water and possibly increasing the risk for bone fracture. It just doesn't make sense at all."(95)

Radiologic changes in bone occur when fluoride exposure is 5 mg/day, according to the late Dr. George Waldbott, author of Fluoridation: The Great Dilemma. While this 5 mg/day level is the amount of fluoride ingested by most people living in fluoridated areas,(96) the number increases for diabetics and laborers, who can ingest up to 20 mg of fluoride daily. In addition, a survey conducted by the Department of Agriculture shows that 3% of the U.S. population drinks 4 liters or more of water every day. If these individuals live in areas where the water contains a fluoride level of 4 ppm, allowed by the EPA, they are ingesting 16 mg/day from the consumption of water alone, and are thus at greater risk for getting skeletal fluorosis.(97)

Bone Fractures

At one time, fluoride therapy was recommended for building denser bones and preventing fractures associated with osteoporosis. Now several articles in peer-reviewed journals suggest that fluoride actually causes more harm than good, as it is associated with bone breakage. Three studies reported in The Journal of the American Medical Association showed links between hip fractures and fluoride.(98, 99, 100) Findings here were, for instance, that there is "a small but significant increase in the risk of hip fractures in both men and women exposed to artificial fluoridation at 1 ppm."(101) In addition, the New England Journal of Medicine reports that people given fluoride to cure their osteoporosis actually wound up with an increased nonvertebral fracture rate.(102) Austrian researchers have also found that fluoride tablets make bones more susceptible to fractures.(103) The U.S. National Research Council states that the U.S. hip fracture rate is now the highest in the world.(104)

A 2000 article in the journal Fluoride describes the bone effects of fluoride in detail.(105) Fluoride may increase bone quantity (osteofluorosis, osteosclerosis) but also decrease bone quality and bone strength. It is well known that pharmacological doses of fluoride increase the risk of torsion-type fractures (such as hip fractures) despite the appearance of greater bone density. Conventional medicine interprets the observed fluoride-induced increase of serum alkaline phosphatase concentration as a sign of osteoblast activity. Actually, it is a reflection of increased mortality of osteocytes within bone. Osteocytes are rich in alkaline phosphatase, which is released when the cells are killed by fluoride. It is unlikely, therefore, that a window of fluoride-induced bone benefit exists.(106)

Louis V. Avioli, professor at the Washington University School of Medicine, says in a 1987 review of the subject: "Sodium fluoride therapy is accompanied by so many medical complications and side effects that it is hardly worth exploring in depth as a therapeutic mode for postmenopausal osteoporosis, since it fails to decrease the propensity for hip fractures and increases the incidence of stress fractures in the extremities."(107)

Fluoride's deleterious effect on bone is well documented. Early experiments using large doses of fluoride as a treatment for osteoporosis had disastrous results. Dr. C. Rich warned that rather than strengthening bones, fluoride could cause osteoarthritis, as well as gastric pain, calcification of the arteries, and visual disturbances.(108)

Dr. Paul Connett cites two epidemiological studies suggesting a possible association with osteosarcoma, bone cancer, in young men living in fluoridated areas.(109) One is the report of the U.S. National Toxicology Program mentioned earlier, which first uncovered the epidemiological evidence of increasedosteosarcoma in boys and young men living in fluoridated areas.(110) The second is a study conducted by the New Jersey Department of Health. Dr. Perry Cohn studied the incidence of the rare bone cancer in seven New Jersey counties relative to water fluoridation. In fluoridated areas incidence of osteosarcoma in boys under the age of ten was 4.6 times higher than in unfluoridated areas, 3.5 times higher in the 10 to 19 age group, and over twice as high in the 20 to 49 age group.(111)

Scientists at Yale University discovered that doses as low as 1 ppm of fluoride decrease bone strength and elasticity, making fracture more likely.(112) Another group of researchers found that fluoride accelerated the development of osteoporosis.(113) A 1992 study of elderly patients found 'a small but significant increase in the risk of hip fracture in both men and women exposed to artificial fluoridation at 1 part per million'. As with the bone cancer, the adverse effects of fluoride accumulation on bone strength were greater with men.(114)

Fluoride has the potential to increase skeletal mass to a greater extent than any other pharmacologic agent, yet it has proven difficult to translate this into therapeutic benefit for patients with low bone mass in diseases such as osteoporosis, according to a 1996 study by Michigan's Center for Osteoporosis Research. This apparent paradox can be explained in part by toxic actions of the ion on skeletal mineralization, impairment of the normal processes of bone resorption, and fluoride-induced decreases in strength per unit of bone (mass or volume).(115)

Belgian arthritis researchers reviewed thirty years clinical research on fluoride in the treatment of osteoporosis. They point out that fluoride has a dual effect on osteoblasts (the cells from which bones are made). On the one hand, it increases the birthrate of osteoblasts, while on the other hand it has a toxic effect on the individual cell with mineralization impairment and reduced apposition rate resembling osteomalacia. Fluoride has a positive effect on axial bone density, they say, but the axial bone gain is not matched by similar changes in cortical bone. (The cortical bone is the hard outer part of bone where a bone's main strength lies.)(116)

Among the studies cited, two show an increased rate of hip fracture among patients treated with high doses of fluoride (50-75 mg per day). (117, 118)

In an experiment on cow bone, fluoride treatment reduced the mechanical strength of bone tissue by converting small amounts of bone mineral to mostly calcium fluoride. This action reduces the structurally effective bone mineral content and also possibly effects the interface bonding between the bone mineral and the organic matrix of the bone tissue.(119) A Polish study published in 1999 found that treatment with fluoridated water decreases the bending strength of the femoral neck and shaft in laboratory rats.

A New Zealand review of recent scientific literature reveals a consistent pattern of evidence--hip fractures, skeletal fluorosis, the effect of fluoride on bone structure, fluoride levels in bones and osteosarcomas--pointing to the existence of causal mechanisms by which fluoride damages bones. Public health authorities in Australia and New Zealand have appeared reluctant to consider openly and frankly the implications of this and earlier scientific evidence unfavourable to the continuation of the fluoridation of drinking water supplies.(120)

Dr. Connett reports that, of eighteen studies conducted since 1990, ten have found an association between water fluoridation and hip fractures in the elderly.(121) "One study found a dose-related increase in hip fracture as the concentration of fluoride rose from 1 ppm to 8 ppm (Li et al, 1999, to be published).(122) Hip fracture is a very serious issue for the elderly, as a quarter of those who have a hip fracture die within a year of the operation, while 50 percent never regain an independent existence."

Fluoride Poisoning

In May 1992, 260 people were poisoned, and one man died, in Hooper Bay, Alaska, after drinking water contaminated with 150 ppm of fluoride. The acci dent was attributed to poor equipment and an unqualified operator.(123) Was this a fluke? Not at all. Over the years, the CDC has recorded several incidents of excessive fluoride permeating the water supply and sickening or killing people. We don't usually hear about these occurrences in news reports, but interested citizens have learned the truth from data obtained under the Freedom of Information Act. Here is a partial list of toxic spills we have not been told about:

* July 1993 - Chicago, Illinois: Three dialysis patients died and five experienced toxic reactions to the fluoridated water used in the treatment process. The CDC was asked to investigate, but to date there have been no press releases.

* May 1993 - Kodiak, Alaska (Old Harbor): The population was warned not to consume water due to high fluoride levels. They were also cautioned against boiling the water, since this concentrates the substance and worsens the danger. Although equipment appeared to be functioning normally, 22-24 ppm of fluoride was found in a sample.

* July 1992 - Marin County, California: A pump malfunction allowed too much fluoride into the Bon Tempe treatment plant. Two million gallons of fluoridated water were diverted to Phoenix Lake, elevating the lake surface by more than two inches and forcing some water over the spillway.

* December 1991 - Benton Harbor, Michigan: A faulty pump allowed approximately 900 gallons of hydrofluosilicic acid to leak into a chemical storage building at the water plant. City engineer Roland Klockow stated, "The concentrated hydrofluosilicic acid was so corrosive that it ate through more than two inches of concrete in the storage building." This water did not reach water consumers, but fluoridation was stopped until June 1993. The original equipment was only two years old.

* July 1991 - Porgate, Michigan: After a fluoride injector pump failed, fluoride levels reached 92 ppm and resulted in approximately 40 children developing abdominal pains, sickness, vomiting, and diarrhea at a school arts and crafts show.

* November 1979 - Annapolis, Maryland: One patient died and eight became ill after renal dialysis treatment. Symptoms included cardiac arrest (resuscitated), hypotension, chest pain, difficulty breathing, and a whole gamut of intestinal problems. Patients not on dialysis also reported nausea, headaches, cramps, diarrhea, and dizziness. The fluoride level was later found to be 35 ppm; the problem was traced to a valve at a water plant that had been left open all night.(124)

Instead of addressing fluoridation's problematic safety record, officials have chosen to cover it up. For example, the ADA says in one booklet distributed to health agencies that "Fluoride feeders are designed to stop operating when a malfunction occurs... so prolonged over-fluoridation becomes a mechanical impossibility."(125) In addition, the information that does reach the population after an accident is woefully inaccurate. A spill in Annapolis, Maryland, placed thousands at risk, but official reports reduced the number to eight.(126) Perhaps officials are afraid they will invite more lawsuits like the one for $480 million by the wife of a dialysis patient who became brain-injured as the result of fluoride poisoning.

Not all fluoride poisoning is accidental. For decades, industry has knowingly released massive quantities of fluoride into the air and water. Disenfranchised communities, with people least able to fight back, are often the victims. Medical writer Joel Griffiths relays this description of what industrial pollution can do, in this case to a devastatingly poisoned Indian reservation:

"Cows crawled around the pasture on their bellies, inching along like giant snails. So crippled by bone disease they could not stand up, this was the only way they could graze. Some died kneeling, after giving birth to stunted calves. Others kept on crawling until, no longer able to chew because their teeth had crumbled down to the nerves, they began to starve...." They were the cattle of the Mohawk Indians on the New York-Canadian St. Regis Reservation during the period 1960-1975, when industrial pollution devastated the herd - and along with it, the Mohawks' way of life. ...Mohawk children, too, have shown signs of damage to bones and teeth."(127)

Mohawks filed suit against the Reynolds Metals Company and the Aluminum Company of America (Alcoa) in 1960, but ended up settling out of court, where they received $650,000 for their cows.(128)

Cancer

Numerous studies demonstrate links between fluoridation and cancer; however, agencies promoting fluoride consistently refute or cover up these findings.

Even in the earliest days of fluoridation there were clear indications of the fluoride-cancer link. In the early 1950s Dr. Alfred Taylor, a biochemist at the University of Texas conducted a series of experiments in which cancer-prone mice consuming water treated with sodium fluoride were found to have shorter lifespans than similar mice drinking distilled water.(131) Taylor's studies were carried out twice, because after the first run the scientist himself discovered that the chow that his mice had eaten had itself contained fluoride, thus clouding the results. On his own initiative, Taylor ran the whole experiment a second time. The second run, with mice fed fluoride-free chow, was conclusive. Clearly fluoride could no longer be considered a harmless additive to drinking water.(132)

John Remington Graham and Pierre-Jean Morin, in their exhaustive survey of fluoridation litigation(133) observe that "Taylor's work was published at a politically sensitive time, because the last stages of the much-boasted surveys at Newburgh and Kingston were underway. The obvious meaning of Dr. Taylor's results was that a possible danger to human health had been overlooked, and that widespread fluoridation should be delayed until the situation had been clarified. However, the ADA and the USPHS had already endorsed and begun the drive to promote fluoridation."(134)

What happened next is a classic study in denial. The Final Report published by the authors of the Newburgh-Kingston study refers only to the results of Taylor's first round of tests, even though his second, conclusive round had been peer-reviewed and published over two years before. They wrote:

"The reports by Alfred Taylor, a biochemist at the University of Texas, on the increased incidence of cancer in mice drinking fluoride treated water have been shown to be unfounded, since the food he was giving the mice had many times the fluoride content of drinking water, and the food was supplied to both the control and the experimental groups. Subsequent tests did not confirm the differences."(135)

And this same denial has been repeated over and over for the succeeding 45 years by the United States Public Health Service and its affiliates. Graham and Morin cite a standard history of the National Institute of Dental Research, published over 35 years later, alleging that Dr. Taylor refrained from publishing his findings "because he was unable to confirm those results in a second experiment."(136) The author of this fabrication goes on to say that "a literature search of scientific journals failed to show any publication of this work by Taylor...."(137) Legal scholars Graham and Morin comment: "The most powerful forensic evidence of the importance of Dr. Taylor's work is that the USPHS officials have done so much to conceal it."(138)

That was not to be the last study to reveal carcinogenic effects for fluoride, and it was not to be the last fluoride-related cover-up. In 1977, Dr. John Yiamouyiannis and Dr. Dean Burk, former chief chemist at the National Cancer Institute, released a study that linked fluoridation to 10,000 cancer deaths per year in the U.S. Their inquiry, which compared cancer deaths in the ten largest fluoridated American cities to those in the ten largest unfluoridated cities between 1940 and 1950, discovered a 5% greater rate in the fluoridated areas.(139) The NCI disputed these findings, since an earlier analysis of theirs apparently failed to pick up these extra deaths. Federal authorities claimed that Yiamouyiannis and Burk were in error, and that any increase was caused by statistical changes over the years in age, gender, and racial composition.(140)

In order to settle the question of whether or not fluoride is a carcinogen, a Congressional subcommittee instructed the National Toxicology Program (NTP) to perform another investigation.(141) That study, due in 1980, was not released until 1990. However, in 1986, while the study was delayed, the EPA raised the standard fluoride level in drinking water from 2.4 to 4 ppm.(142) After this step, some of the government's own employees in NFFE Local 2050 took what the Oakland Tribune termed the "remarkable step of denouncing that action as political."(143)

When the NTP study results became known in early 1990, union president Dr. Robert Carton, who works in the EPA's Toxic Substances Division, published a statement. It read, in part:

"Four years ago, NFFE Local 2050, which represents all 1100 professionals at EPA headquarters, alerted then Administrator Lee Thomas to the fact that the scientific support documents for the fluoride in drinking water standard were fatally flawed. The fluoride juggernaut proceeded as it apparently had for the last 40 years - without any regard for the facts or concern for public health.

"EPA raised the allowed level of fluoride before the results of the rat/mouse study ordered by Congress in 1977 was complete. Today, we find out how irresponsible that decision was. The results reported by NTP, and explained today by Dr. Yiamouyiannis, are, as he notes, not surprising considering the vast amount of data that caused the animal study to be conducted in the first place. The results are not surprising to NFFE Local 2050 either. Four years ago we realized that the claim that there was no evidence that fluoride could cause genetic effects or cancer could not be supported by the shoddy document thrown together by the EPA contractor.

"It was apparent to us that EPA bowed to political pressure without having done an in-depth, independent analysis, using in-house experts, of the currently existing data that show fluoride causes genetic effects, promotes the growth of cancerous tissue, and is likely to cause cancer in humans. If EPA had done so, it would have been readily apparent - as it was to Congress in 1977 - that there were serious reasons to believe in a cancer threat.

"The behavior by EPA in this affair raises questions about the integrity of science at EPA and the role of professional scientists, lawyers and engineers who provide the interpretation of the available data and the judgements necessary to protect the public health and the environment. Are scientists at EPA there to arrange facts to fit preconceived conclusions? Does the Agency have a responsibility to develop world-class experts in the risks posed by chemicals we are exposed to every day, or is it permissible for EPA to cynically shop around for contractors who will provide them the 'correct' answers?"(144)

What were the NTP study results? Out of 130 male rats that ingested 45 to 79 ppm of fluoride, 5 developed osteosarcoma, a rare bone cancer. There were cases, in both males and females at those doses, of squamous cell carcinoma in the mouth.(145) Both rats and mice had dose-related fluorosis of the teeth, and female rats suffered osteosclerosis of the long bones.(146)

When Yiamouyiannis analyzed the same data, he found mice with a particularly rare form of liver cancer, known as hepatocholangiocarcinoma. This cancer is so rare, according to Yiamouyiannis, that the odds of its appearance in this study by chance are 1 in 2 million in male mice and l in 100,000 in female mice.(147) He also found precancerous changes in oral squamous cells, an increasein squamous cell tumors and cancers, and thyroid follicular cell tumors as a result of increasing levels of fluoride in drinking water.(148)

A March 13, 1990, New York Times article commented on the NTP findings:

"Previous animal tests suggesting that water fluoridation might pose risks to humans have been widely discounted as technically flawed, but the latest investigation carefully weeded out sources of experimental or statistical error, many scientists say, and cannot be discounted."(149)

In the same article, biologist Dr. Edward Groth notes: "The importance of this study...is that it is the first fluoride bioassay giving positive results in which the latest state-of-the-art procedures have been rigorously applied... It has to be taken seriously."(150)

On February 22, 1990, the Medical Tribune, an international medical news weekly received by 125,000 doctors, offered the opinion of a federal scientist who preferred to remain anonymous:

"It is difficult to see how EPA can fail to regulate fluoride as a carcinogen in light of what NTP has found. Osteosarcomas are an extremely unusual result in rat carcinogenicity tests. Toxicologists tell me that the only other substance that has produced this is radium....The fact that this is a highly atypical form of cancer implicates fluoride as the cause. Also, the osteosarcomas appeared to be dose-related, and did not occur in controls, making it a clean study."(151)

Public health officials were quick to assure a concerned public that there was nothing to worry about! The ADA said the occurrence of cancers in the lab may not be relevant to humans since the level of fluoridation in the experimental animals' water was so high. But the Federal Register, which is the handbook of government practices, disagrees: "The high exposure of experimental animals to toxic agents is a necessary and valid method of discovering possible carcinogenic hazards in man. To disavow the findings of this test would be to disavow those of all such tests, since they are all conducted according to this standard."(152) As a February 5, 1990, Newsweek article pointed out, "such megadosing is standard toxicological practice. It's the only way to detect an effect without using an impossibly large number of test animals to stand in for the humans exposed to the substance."(153) And as the Safer Water Foundation explains, higher doses are generally administered to test animals to compensate for the animals' shorter life span and because humans are generally more vulnerable than test animals on a body-weight basis.(154)

Several other studies link fluoride to genetic damage and cancer. An article in Mutation Research says that a study by Proctor and Gamble, the very company that makes Crest toothpaste, did research showing that 1 ppm fluoride causes genetic damage.(155) Results were never published but Proctor and Gamble called them "clean," meaning animals were supposedly free of malignant tumors. Not so, according to scientists who believe some of the changes observed in test animals could be interpreted as precancerous.(156) Yiamouyiannis says the Public Health Service sat on the data, which were finally released via a Freedom of Information Act request in 1989. " Since they are biased, they have tried to cover up harmful effects," he says. "But the data speaks for itself. Half the amount of fluoride that is found in the New York City drinking water causes genetic damage."(157)

A National Institutes of Environmental Health Sciences publication, Environmental and Molecular Mutagenesis, also linked fluoride to genetic toxicity when it stated that "in cultured human and rodent cells, the weight of evidence leads to the conclusion that fluoride exposure results in increased chromosome aberrations." (158) The result of this is not only birth defects but the mutation of normal cells into cancer cells. The Journal of Carcinogenesis further states that "fluoride not only has the ability to transform normal cells into cancer cells but also to enhance the cancer-causing properties of other chemicals." (159)

Surprisingly, the PHS put out a report called "Review of fluoride: benefits and risks," in which they showed a substantially higher incidence of bone cancer in young men exposed to fluoridated water compared to those who were not. The New Jersey Department of Health also found that the risk of bone cancer was about three times as high in fluoridated areas as in nonfluoridated areas.(160)

Despite cover-up attempts, the light of knowledge is filtering through to some enlightened scientists. Regarding animal test results, the director of the U.S. National Institute of Environmental Health Sciences, James Huff, does say that "the reason these animals got a few osteosarcomas was because they were given fluoride...Bone is the target organ for fluoride."(161) Toxicologist William Marcus adds that "fluoride is a carcinogen by any standard we use. I believe EPA should act immediately to protect the public, not just on the cancer data, but on the evidence of bone fractures, arthritis, mutagenicity, and other effects."(162)

Paul Connett notes that "some of the earliest opponents of fluoride were biochemists and at least 14 Nobel prize winners are among numerous scientists who have expressed their reservations about the practice of fluoridation."(163) He cites Dr, James Sumner, who won the Nobel Prize for his work on enzyme chemistry, who says, "We ought to go slowly. Everybody knows fluorine and fluoride are very poisonous substances...We use them in enzyme chemistry to poison enzymes, those vital agents in the body. That is the reason things are poisoned; because the enzymes are poisoned and that is why animals and plants die."(164)

It is instructive to note that The fluoride compounds that are added to our drinking water are not pharmaceuticals. They are direct, unfiltered waste products of the aluminum and fertilizer industries.

Fluoride and Lead

Fluoride and its various compounds are toxic all by themselves, but their interaction with other toxic metals are of increasing concern. Research published in the December 2000 issue of the journal NeuroToxicology warns that public drinking water treated with sodium silicofluoride or fluosilicic acid, known silicofluorides (SiFs), is linked to higher uptake of lead in children.(165)165 Less than 10% of fluoridation systems in the US use sodium fluoride, the substance first used to fluoridate public drinking water in 1945. SiF's are now used to treat drinking water for 140 million Americans. Yet the safety of SiFs has never been tested, nor have they been approved by the FDA.

The research was conducted by a team led by Roger D. Masters, Dartmouth College Research Professor and Nelson A. Rockefeller Professor of Government Emeritus, and Myron J. Coplan, a consulting chemical engineer, formerly Vice President of Albany International Corporation. The team has now studied the blood lead levels in over 400,000 children in three different samples. In each case, they found a significant link between SiF-treated water and elevated blood lead levels. The researchers found that the greatest likelihood of children having elevated blood lead levels occurs when they are exposed both to known risk factors, such as old house paint and lead in soil or water, and to SiF-treated drinking water.(166)

"Our research needs further laboratory testing," said Masters. "This should have the highest priority because our preliminary findings show correlations between SiF use and more behavior problems due to known effects of lead on brain chemistry." Also requiring further examination is German research that shows SiFs inhibit cholinesterase, an enzyme that plays an important role in regulating neurotransmitters.(167)

"If SiFs are cholinesterase inhibitors, this means that SiFs have effects like the chemical agents linked to Gulf War Syndrome, chronic fatigue syndrome and other puzzling conditions that plague millions of Americans," said Masters. "We need a better understanding of how SiFs behave chemically and physiologically."(168)

"We should stop using silicofluorides in our public water supply until we know what they do," says Masters.(169)

Fluoride and Aluminum

Lead isn't the only metal that interacts with fluoride in a toxic combination. Aluminum is another.

In 1976, Dr. D. Allman and coworkers from Indiana University School of Medicine fed animals 1 part-per-million (ppm) fluoride and found that in the presence of aluminum, in a concentration as small as 20 parts per billion, fluoride is able to cause an even larger increase in cyclic AMP levels. Cyclic AMP inhibits the migration rate of white blood cells, as well as the ability of the white blood cell to destroy pathogenic (disease-causing) organisms. The fact that fluoride toothpastes and school based mouth rinses are packaged in aluminum accentuates the effect on the body.(170)

Research conducted by Mullenix and colleagues in 1995 indicated that rats treated with low doses of fluoride cause sex- and dose-specific behavioral aberrations with a common pattern.(171) Rats exposed prenatally became hyperactive, while those exposed post-natally became hypoactive. This effect was confirmed by a 2001 study in which administration of sodium fluoride with drinking water produced both behavioural and dental toxicities. A suppression of spontaneous motor activity, a shortening of rota-rod endurance time, a decreased body weight gain and food intake, a suppression of total cholinesterase and acetylcholinesterase activities and dental lesion were observed in test animals. Serum fluoride concentration was raised markedly and that of calcium was decreased in the animals.(172)

A 1998 study by Julie A. Varner and colleagues at the Psychology Department of Binghamton University (NY) shows that neurotoxic effects like these are enhanced by the synergetic action of fluoride and aluminum.(173) Varner describes "alterations in the nervous system resulting from chronic administration of the fluoroaluminum complex or equivalent levels of fluoride in the form of sodium-fluoride. The rats were given fluoride in drinking water at the same level deemed "optimal" by pro-fluoridation groups, namely 1 part per million (1 ppm). Most pronounced damage was seen in animals that got the fluoride in conjunction with aluminum. The pathological changes found in the brain tissue of the animals were similar to the alterations found in the brains of people with Alzheimer's disease and dementia. The authors speculate that fluoride enables aluminum to cross the blood-brain barrier. These results are especially disturbing because of the low dose level of fluoride that shows the toxic effect in rats - rats are more resistant to fluoride than humans."(174)

Another study done in Czechoslovakia adds force to the idea that aluminum may act synergetically with fluoride to trigger the mechanisms of Alzheimer's disease. The study shows that some of pathologic changes associated with AD are not induced by aluminum alone, but by the aluminofluoride complexes. These complexes may act as the initial signal stimulating impairment of homeostasis, degeneration and death of the cells. By influencing energy metabolism these complexes can accelerate the aging and impair the functions of the nervous system. "In respect to the etiology of AD, the long term action of aluminofluoride complexes may represent a serious and powerful risk factor for the development of AD," the authors conclude.(175)

Incidentally, if you're thinking that fluoride and aluminum exist in separate worlds and are unlikely to find each other in the normal course of events, think again. Fluoride is a direct byproduct of aluminum production. Aluminum is often added to drinking water as a flocculating agent, by the same folks who add the fluoride-your local water authority. Aluminum and fluoride form a number of complexes, the most deadly of these being aluminum tetrafluoride.(176) Czech researchers have shown that the body reacts to aluminum tetrafluoride as if it were a phosphate ion capable of triggering G proteins. G-proteins are water-soluble substances (i.e. hormones, neurotransmitters, and growth factors) that transmit messages from the outside to the inside of a cell.(177) Aluminum tetrafluoride is capable of switching on G proteins without hormones, neurotransmitters, or growth factors present.(178) 'This, notes Paul Connett, 'is the most worrisome aspect of fluoride subtle biochemistry."(179)

Fluoride and the Pineal Gland

Another concern is fluoride's effect on the pineal gland, a small but powerful structure located between the right and left hemispheres of the brain. The pineal gland secretes melatonin, a hormone that affects such functions as sleep cycles, jet lag, hybernation in animals, immunity, and the onset of puberty. Jennifer Luke, Ph.D., found that the pineal gland attracts fluoride, and, thereby, interferes with melatonin's functions.(180) In autopsy studies she discovered extremely high concentrations of fluoride in the gland, averaging 9,000 ppm, going up to 21,000 ppm in some cases.(181) And in an accompanying study of fluoride-treated Mongolian gerbils (the animal considered most favorable for studying effects on the pineal gland) Luke found lower levels of melatonin and earlier onset of puberty.

This research is highly suggestive. People with insomnia could be suffering as a result of fluoride's interference with melatonin production. Currently more than half the population of the United States suffers from some form of sleep disturbance.(182) Sleep deprivation promotes reduced immunity. Sleep-challenged people are more likely to suffer depression, stroke, or heart disease than their well-rested peers. Numerous studies have correlated insufficient melatonin production with an earlier-than-usual onset of puberty.(183, 184)

This recalls the 1955 Newburgh-Kingston study, which produced some extremely puzzling results that scientists have yet to explain. One was the finding that girls in fluoridated Newberg were reaching menstruation five months earlier on average than the girls in unfluoridated Kingston. This raises the question, does fluoride contribute to the alarming rates of early puberty that we are seeing?(185) Premature menstruation is associated with a variety of ills, including breast cancer and obesity. A 2001 study published in the American Journal of Public Health reveals that early maturation nearly doubled the odds of being obese.(186)

Reproductive Effects

Fluoride has long been known to undermine fertility in animals and man. (187) In 1951 commercial chinchilla breeder named W.R. Cox reported reproductive anomalies in commercially raised chinchillas fed with a high-fluoride animal feed.(188) When Cox changed to a low-fluoride feed, "there were increases in the number of offspring born; the number of litters, and the numbers born alive. The adult mortality rate decreased from 14.6% in 1951 to 3.3% in 1952. A number of abnormalities associated with fluoride-contaminated feed were passed on through multiple generations."(189)

Cox, a layman, studied the scientific literature, and found more than 1400 studies indicating fluoride's adverse effect on animals, especially soft tissue damage. Cox was surprised to find that the scientists advocating public water fluoridation at the time showed no interest in these studies or their possible implications for human health.(190)

SC Freni participated in a 1991 USPHS review of the toxicity of fluoride. Searching for studies that correlated fluoride exposure with reproductive effects in humans, he discovered that in almost 50 years of fluoridation, no one had ever study fluoride's effect on the human fetus.(191)

Freni's 1994 review of fluoride toxicity the National Center for Toxicological Research showed decreased fertility in most animal species studied. Freni then investigated whether fluoride would also affect human birth rates. He studied counties in which the water had a fluoride content of more than 3 ppm. Most regions he studied showed an association of decreasing total fertility rates (TFR) with increasing fluoride levels. There was no evidence that this outcome resulted from selection bias, inaccurate data, or improper analytical methods.(192) Freni speculated that fluoride might lower protein synthesis in osteoblasts or that it inhibits the adenylyl cyclase system in human spermatozoa.(193)

In a 1994 study of mature rats treated with sodium fluoride, Narayana and Chinoy(194) found that fluoride interferes with androgenesis and damaged the testes by inhibiting the action of testosterone. Another study by the same team studied human spermatozoa treated with 25, 50, and 250 mM of fluoride for 5, 10, and 20 minutes. Silver nitrate staining of fluoride-treated sperm revealed elongated heads, deflagellation, and loss of the acrosome together with coiling of the tail. Sperm glutathione levels also showed a time-dependent decrease with complete depletion after 20 minutes, indicating rapid glutathione oxidation in detoxification of the NaF. The altered lysosomal enzyme activity and glutathione levels together with morphologic anomalies resulted in a significant decline in sperm motility with an effective dose of 250 mM.(195)

Fluoride and Intelligence

Several other studies link fluoride exposure to adverse effects on intelligence. One investigation conducted in China measured the intelligence of children aged 8 to 13 with non, slight, medium, and serious fluorosis. It demonstrated a 15-19 point decrease in IQ among children in the fluorosis area as compared with the non-fluorosis area.(196) Another study of children's intelligence and the metabolism of iodine and fluorine, also in China, revealed that exposure to high levels of fluoride produced increased prevalence of thyroid enlargement (29.8%) and dental fluorosis (72.9%), and a slightly lower average IQ as compared to control areas. The IQ differential was more pronounced (16.8%) when lower intelligence children were studied separately.(197) Paul Connett cites a recent review by the Greater Boston Physicians for Social Responsibility which found that fluoride interferes with brain function in young animals and children.(198)

Enzyme Toxicity and Genetic Damage

Fluoride is a potent enzyme poison. Enzymes are special types of proteins, known as catalysts, that trigger thousands of chemical reactions in the body. Enzymes are vital to our very existence, writes Dr. Anthony Cichoke: 'During every moment of our lives, enzymes keep us going. At this very instant, millions of tiny enzymes are working throughout your body causing reactions to take place. You couldn't breathe, hold or turn the pages of this book, read its words, eat a meal, taste the food, or hear a telephone ring without enzymes. Even minute doses of 1 ppm of fluoride could prevent essential biological reactions from taking place."(199)

While the mechanisms of enzyme destruction were not well understood in the 1940's and 50's, scientists now believe that it could be due to fluoride's interference with magnesium, a vital cofactor needed by many enzymes to perform catalytic functions. Another reason could be fluoride's ability to form strong bonds with hydogen. Hydrogen, a strongly positive element, binds easily with the strong negatively-charged fluoride. Dr. Paul Connett explains: "Hydrogen bonding is at the very heart and soul of biochemistry. Protein structure and function revolve around hydrogen bonds. Hydrogen gives shape, and that shape can be easily manipulated with little energy. Enzymes usually catalyze around hydrogen bonds. In addition, the two strands of DNA are held together with hydrogen bonds. So, you're striking at the very heart of biology. It's a huge red flag to be extremely careful about introducing fluoride to any living system.(200)

While critics argue that only high doses cause such effects, studies suggest that even a supposedly "safe" concentration of 1 ppm of fluoride added to drinking water is able to interfere with critical biological functions. This was demonstrated in 1977 at Austria's Siebersdorf Research Center by Dr. W. Klein and colleagues, who found that even this low dose inhibited DNA repair enzyme activity by 50 percent and caused genetic and chromosome damage.(201) A similar study conducted at the University of Missouri confirmed these results.(202) Scientists at Poland's Pomeranian Medical Academy found that as little as 0.6 ppm of fluoride produced chromosomal damage to human white blood cells.(203)

Sperm cells displayed "a highly significant increase in mutation" after being treated with fluoride at Holland's Leiden University.(204) And studies at Germany's Central Laboratory for Mutagenicity Testing(205) and by Drs. Yiamouyannis and Burk at Columbia University(206) showed that it also caused genetic damage to eggs in both insects and laboratory animals.

The Challenge of Eliminating Fluoride

Given all the scientific challenges to the idea of the safety of fluoride, why does it remain a protected contaminant? As Susan Pare of the Center for Health Action asks, "...even if fluoride in the water did reduce tooth decay, which it does not, how can the EPA allow a substance more toxic than Alar, red dye #3, and vinyl chloride to be injected purposely into drinking water?"(207)

This is certainly a logical question and, with all the good science that seems to exist on the subject, you would think that there would be a great deal of interest in getting fluoride out of our water supply. Unfortunately, that hasn't been the case. As Dr. William Marcus, a senior science advisor in the EPA's Office of Drinking Water, has found, the top governmental priority has been to sweep the facts under the rug and, if need be, to suppress truth-tellers. Marcus explains (208) that fluoride is one of the chemicals the EPA specifically regulates, and that he was following the data coming in on fluoride very carefully when a determination was going to be made on whether the levels should be changed. He discovered that the data were not being heeded. But that was only the beginning of the story for him. Marcus recounts what happened:

"The studies that were done by Botel Northwest showed that there was an increased level of bone cancer and other types of cancer in animals....in that same study, there were very rare liver cancers, according to the board-certified veterinary pathologists at the contractor, Botel. Those really were very upsetting because they were hepatocholangeal carcinomas, very rare liver cancers....Then there were several other kinds of cancers that were found in the jaw and other places.

"I felt at that time that the reports were alarming. They showed that the levels of fluoride that can cause cancers in animals are actually lower than those levels ingested in people (who take lower amounts but for longer periods of time).

"I went to a meeting that was held in Research Triangle Park, in April 1990, in which the National Toxicology Program was presenting their review of the study. I went with several colleagues of mine, one of whom was a board-certified veterinary pathologist who originally reported hepatocholangeal carcinoma as a separate entity in rats and mice. I asked him if he would look at the slides to see if that really was a tumor or if the pathologists at Botel had made an error. He told me after looking at the slides that, in fact, it was correct.

"At the meeting, every one of the cancers reported by the contractor had been downgraded by the National Toxicology Program. I have been in the toxicology business looking at studies of this nature for nearly 25 years and I have never before seen every single cancer endpoint downgraded.... I found that very suspicious and went to see an investigator in the Congress at the suggestion of my friend, Bob Carton. This gentleman and his staff investigated very thoroughly and found out that the scientists at the National Toxicology Program down at Research Triangle Park had been coerced by their superiors to change their findings."

Once Dr. Marcus acted on his findings, something ominous started to happen in his life:

"...I wrote an internal memorandum and gave it to my supervisors. I waited for a month without hearing anything. Usually, you get a feedback in a week or so. I wrote another memorandum to a person who was my second-line supervisor explaining that if there was evena slight chance of increased cancer in the general population, since 140 million people were potentially ingesting this material, that the deaths could be in the many thousands. Then I gave a copy of the memorandum to the Fluoride Work Group, who waited some time and then released it to the press.

"Once it got into the press all sorts of things started happening at EPA -- I was getting disciplinary threats, being isolated, and all kinds of things which ultimately resulted in them firing me on March 15, 1992."(209)

In order to be reinstated at work, Dr. Marcus took his case to court. In the process, he learned that the government had engaged in various illegal activities, including 70 felony counts, in order to get him fired. At the same time, those who committed perjury were not held accountable for it. In fact, they were rewarded for their efforts:

"When we finally got the EPA to the courtroom...they admitted to doing several things to get me fired. We had notes of a meeting...that showed that fluoride was one of the main topics discussed and that it was agreed that they would fire me with the help of the Inspector General. When we got them on the stand and showed them the memoranda, they finally remembered and said, oh yes, we lied about that in our previous statements.

"Then...they admitted to shredding more than 70 documents that they had in hand - Freedom of Information requests. That's a felony.... In addition, they charged me with stealing time from the government. They...tried to show...that I had been doing private work on government time and getting paid for it. When we came to court, I was able to show that the time cards they produced were forged, and forged by the Inspector General's staff...."(210)

For all his efforts, Dr. Marcus was rehired, but nothing else has changed: "The EPA was ordered to rehire me, which they did. They were given a whole series of requirements to be met, such as paying me my back pay, restoring my leave, privileges, and sick leave and annual leave. The only thing they've done is put me back to work. They haven't given me any of those things that they were required to do."(211)

What is at the core of such ruthless tactics? John Yiamouyiannis feels that the central concern of government is to protect industry, and that the motivating force behind fluoride use is the need of certain businesses to dump their toxic waste products somewhere. They try to be inconspicuous in the disposal process and not make waves. "As is normal, the solution to pollution is dilution. You poison everyone a little bit rather than poison a few people a lot. This way, people don't know what's going on."(212) Since the Public Health Service has promoted the fluoride myth for over 50 years, they're concerned about protecting their reputation. So scientists like Dr. Marcus, who know about the dangers, are intimidated into keeping silent. Otherwise, they jeopardize their careers.

Dr. John Lee elaborates: "Back in 1943, the PHS staked their professional careers on the benefits and safety of fluoride. It has since become bureaucratized. Any public health official who criticizes fluoride, or even hints that perhaps it was an unwise decision, is at risk of losing his career entirely. This has happened time and time again. Public health officials such as Dr. Gray in British Columbia and Dr. Colquhoun in New Zealand found no benefit from fluoridation. When they reported these results, they immediately lost their careers.... This is what happens - the public health officials who speak out against fluoride are at great risk of losing their careers on the spot."(213)

Yiamouyiannis adds that for the authorities to admit that they're wrong would be devastating. "It would show that their reputations really don't mean that much.... They don't have the scientific background. As Ralph Nader once said, if they admit they're wrong on fluoridation, people would ask, and legitimately so, what else have they not told us right?"(214)

Accompanying a loss in status would be a tremendous loss in revenue. Yiamouyiannis points out that "the indiscriminate careless handling of fluoride has a lot of companies, such as Exxon, U.S. Steel, and Alcoa, making tens of billions of dollars in extra profits at our expense.... For them to go ahead now and admit that this is bad, this presents a problem, a threat, would mean tens of billions of dollars in lost profit because they would have to handle fluoride properly. Fluoride is present in everything from phosphate fertilizers to cracking agents for the petroleum industry." (215)

Fluoride could only be legally disposed of at a great cost to industry. As Dr. Bill Marcus explains, "There are prescribed methods for disposal and they're very expensive. Fluoride is a very potent poison. It's a registered pesticide, used for killing rats or mice.... If it were to be disposed of, it would require a class-one landfill. That would cost the people who are producing aluminum or fertilizer about $7000+ per 5000- to 6000-gallon truckload to dispose of it. It's highly corrosive."(216)

Another problem is that the U.S. judicial system, even when convinced of the dangers, is powerless to change policy. Yiamouyiannis tells of his involvement in court cases in Pennsylvania and Texas in which, while the judges were convinced that fluoride was a health hazard, they did not have the jurisdiction to grant relief from fluoridation. That would have to be done, it was ultimately found, through the legislative process.(217)

Dr. Hirzy, vice president of the union that represents the scientists who work for the EPA, cites three landmark cases in which judges with "no interest except in the finding of fact and administering justice"(218) ruled against fluoridation. In November, 1978, Judge John Flaherty, now Chief Justice of the Supreme Court of Pennsylvania, issued findings in the case, Aitkenhead v. Borough of West View, tried before him in the Allegheny Court of Common Pleas.

He summarized his findings as follows.

"In my view, the evidence is quite convincing that the addition of sodium fluoride to the public water supply at one part per million is extremely deleterious to the human body, and, a review of the evidence will disclose that there was no convincing evidence to the contrary..."(219)

"Prior to hearing this case, I gave the matter of fluoridation little, if any, thought, but I received quite an education, and noted that the proponents of fluoridation do nothing more than try to impugn the objectivity of those who oppose fluoridation."(220)

In an Illinois decision, Judge Ronald Niemann concludes: "This record is barren of any credible and reputable scientific epidemiological studies and or analysis of statistical data which would support the Illinois Legislature's determination that fluoridation of the water supplies is both a safe and effective means of promoting public health."(221)

Judge Anthony Farris in Texas found: "[That] the artificial fluoridation of public water supplies, such as contemplated by {Houston} City ordinance No. 80-2530 may cause or contribute to the cause of cancer, genetic damage, intolerant reactions, and chronic toxicity, including dental mottling, in man; that the said artificial fluoridation may aggravate malnutrition and existing illness in man; and that the value of said artificial fluoridation is in some doubt as to reduction of tooth decay in man."

Dr. Hirzy, himself a toxicologist and an expert in environmental management and risk assessment, comments: "The significance of Judge Flaherty's statement and his and the other two judges' findings of fact is this: proponents of fluoridation are fond of reciting endorsement statements by authorities, such as those by CDC and the American Dental Association, both of which have long-standing commitments that are hard if not impossible to recant, on the safety and efficacy of fluoridation. Now come three truly independent servants of justice, the judges in these three cases, and they find that fluoridation of water supplies is not justified."(222)

Interestingly, the judiciary seems to have more power to effect change in other countries. Yiamouyiannis states that when he presented the same technical evidence in Scotland, the Scottish court outlawed fluoridation based on the evidence.(223)

Indeed, most of western Europe has rejected fluoridation on the grounds that it is unsafe. In 1971, after 11 years of testing, Sweden's Nobel Medical Institute recommended against fluoridation, and the process was banned. The Netherlands outlawed the practice in 1976, after 23 years of tests. France decided against it after consulting with its Pasteur Institute(224) and Germany rejected the practice because the recommended dosage of 1 ppm was "too close to the dose at which long-term damage to the human body is to be expected."(225) Dr. Lee sums it up: "All of western Europe, except one or two test towns in Spain, has abandoned fluoride as a public health plan. It is not put in the water anywhere. They all established test cities and found that the benefits did not occur and the toxicity was evident."(226)

But Europe is not the sole bastion of sanity in the fluoridation arena. Several municipalities in the United States have taken an enlightened stance on the issue. In 1997, the Natick (MA) Fluoridation Study Committee submitted a comprehensive report to the Town and the Board of Selectmen, overwhelming recommending rejection of fluoridation of the town's water. The committee consisted of scientists, academics, and citizens of the town of Natick. The committee summarized its findings as follows:

* Recent studies of the incidence of cavities in children show little to no difference between fluoridated and non-fluoridated communities.

* Ten to thirty percent (10-30%) of Natick's children will have very mild to mild dental fluorosis if Natick fluoridates its water (up from probably 6% now). Approximately 1% of Natick's children will have moderate or severe dental fluorosis. Dental fluorosis can cause great concern for the affected family and may result in additional dental bills. It should not be dismissed as a "cosmetic" effect.

* Fluoride adversely effects the central nervous system, causing behavioral changes and cognitive deficits. These effects are observed at fluoride doses that some people in the US actually receive.

* There is good evidence that fluoride is a developmental neurotoxicant, meaning that fluoride effects the nervous system of the developing fetus at doses that are not toxic to the mother. The developmental neurotoxicity would be manifest as lower IQ and behavioral changes.

* Water fluoridation shows a positive correlation with increased hip fracture rates in persons 65 years of age and older, based on two recent epidemiology studies.

* Some adults are hypersensitive to even small quantities of fluoride, including that contained in fluoridated water. At least one such person is a Natick resident.

* The impact of fluoride on human reproduction at the levels received from environmental exposures is a serious concern. A recent epidemiology study shows a correlation between decreasing annual fertility rate in humans and increasing levels of fluoride in drinking water.

* Animal bioassays suggest that fluoride is a carcinogen, especially for tissues such as bone (osteosarcoma) and liver. The potential for carcinogenicity is supported by fluoride's genotoxicity and pharmacokinetic properties. Human epidemiology studies to date are inconclusive, but no appropriate major study has been conducted.

* Fluoride inhibits or otherwise alters the actions of a long list of enzymes important to metabolism, growth, and cell regulation.

* Sodium fluorosilicate and fluorosilicic acid, the two chemicals Natick intends to use to fluoridate the water supply, have been associated with increased concentrations of lead in tap water and increased blood lead levels in children, based on case reports and a new, as-yet-unpublished study.

* If Natick fluoridates its water supply at the proposed level, most children under the age of three will daily receive more fluoride than is recommended for them.

The scientific literature supporting these findings is summarized in the full report which also discusses a variety of non-health related concerns that have been raised about water fluoridation.

Conclusion:

The Committee reached the firm conclusion that the risks of overexposure to fluoride far outweigh any current benefit of water fluoridation.

Recommendations:

1. The Natick Fluoridation Study Committee unanimously and emphatically recommends that the town of Natick NOT fluoridate the town water supply.

2. The Natick Fluoridation Study Committee unanimously and emphatically recommends that the Board of Selectmen take appropriate action to ensure that fluoridation of the town water supply does not take place.(227)

Natick is not an isolated case. The town of Bishopville, SC recently voted to discontinue fluoridation. Eureka Springs, Arkansas decided not to begin a proposed fluoridation program. "The citizens of Eureka Springs don't want to be medicated against their will," Mayor Beau Satori said. "They just want fine-tasting water."(228) In fact, the Fluoride Action Network list over 100 municipalities in the US and Canada that have rejected or discontinued fluoride since 1990.(229)

Isn't it time the United States as a whole followed this example? While the answer is obvious, it is also apparent that government policy is unlikely to change without public support. We therefore must communicate with legislators, and insist on one of our most precious resources - pure, unadulterated drinking water. Yiamouyiannis urges all American people to do so. He emphasizes the immediacy of the problem:

"There is no question with regard to fluoridation of public water supplies. It is absolutely unsafe...and should be stopped immediately. This is causing more destruction to human health than any other single substance added purposely or inadvertently to the water supply. We're talking about 35,000 excess deaths a year...10,000 cancer deaths a year...130 million people who are being chronically poisoned. We're not talking about dropping dead after drinking a glass of fluoridated water.... It takes its toll on human health and life, glass after glass."(230)

Dr. Hirzy points to the absurdity of government policy on fluoride. The phosphate fertilizer industry captures hydrofluosilicic acid and uses what would otherwise be an air or water pollutant as a low-cost source of fluoride for water authorities. 'If this material comes out of a smoke stack it's an air pollutant; if it goes out the drain pipe into the river it's a water pollutant. But it is magically converted into some sort of beneficial agent when put in a tank wagon and bled into the drinking water. It's a remarkable transformation."(231)

There are two moral issues in the debate that has largely escaped notice. The first is that, as columnist James Kilpatrick observes, it is "the right of each person to control the drugs he or she takes." Kilpatrick calls fluoridation compulsory mass medication, a procedure that violates the principles of medical ethics.(232) A New York Times editorial agrees:

"In light of the uncertainty, critics [of fluoridation] argue that administrative bodies are unjustified in imposing fluoridation on communities without obtaining public consent.... The real issue here is not just the scientific debate. The question is whether any establishment has the right to decide that benefits outweigh risks and impose involuntary medication on an entire population. In the case of fluoridation, the dental establishment has made opposition to fluoridation seem intellectually disreputable. Some people regard that as tyranny." (233)

But there's a second moral issue that is even broader. That is, can we start being honest with each other, or have we gone too far? Can we stand up against political influence and corruption, and do what is really best for ourselves, our health, and the planet? The issue is no longer whether there is adequate science to make us question fluoride's safety. There is more than enough scientific evidence to support a total ban on fluoride. But industry and the our legislative bodies that are dominated by special interest groups may never get around to admitting the obvious danger, unless we demand it.

The official stance on the fluoride issue reflects a consistent pattern of denial that begins in the earliest years of the twentieth century, with industry's support and encouragement for water fluoridation and continues to this day with propaganda campaigns, scientific disinformation, and out and out attacks on those who have attempted to let the truth be known.

It is time to stop playing games. We must speak out now, and let our leaders know that we want the truth to come out. Otherwise we will have to ask ourselves whether we are capable ever again being honest again.

Endnotes

1 Dr. John Yiamouyiannis, in interview with Gary Null, 3/10/95. His statement is referenced in the Clinical Toxicology of Commercial Products, Fifth Ed., Williams and Wilkins.

2 Joel Griffiths, "Fluoride: Commie Plot or Capitalist Ploy," Covert Action, Fall 1992, Vol. 42, p. 30.

3 Ibid., p. 27.

4 The Fluoride Story. National Institute of Dental Research.

5 Griffiths, p. 28.

6 Ibid.

7 Ibid.

8 Ibid.

9 ibid.

10 Griffiths, op. cit.

11 "H. Trendley Dean." MWWR Weekly. October 22, 1999 / 48(41);935

12 The Fluoride Story.

13 Andreas Schuld, "Fluoride-What's Wrong with This Picture?"

14 J.Colquhoun, Chief Dental Officer, NZ, International Symposium on Fluoridation, Porte Alegre, Brazil, September 1988

15 Proceedings, City of Orville Vs. Public Utilities Commission of the State of Carlifornia, Orville, CA, October 20-21 (1955)

16 AMA Council Hearing, Chicago, August 7, 1957

17 McNeil, The Fight for Fluoridation, 1957, p. 37.

18 Griffiths, op. cit., p. 28.

19 Griffiths, op. cit.

20 G.L. Waldbott et al., Fluoridation: The Great Dilemma, Lawrence, KS, Coronado Press, 1978, p. 295.

21 Paul Farhi, Washington Post, 11/23/91.

22 Griffiths, op. cit., p. 63.

23 Griffiths, op. cit., p. 63.

24 Longevity Magazine, pp. 7-89.

25 The Morning Call, 2/7/90

26 Science, 1/90.

27 Waldbott, op. cit., p. 255.

28 Letter, Rebecca Hammer, 3/83.

29 U.S. Dept. of Health and Human Services, "Policy statement on community water fluoridation," July 22, 1992, Washington, D.C.

30 Chemical and Engineering News, 8/1/88, p. 29; Amer. J. Pub. Health, editorial, 5/89, p. 561; J.A. Brunelle and J.P. Carlos, "Recent trends in dental caries in U.S. children and the effect of water fluoridation," 2/90, p. 276.

31 Los Angeles Times. 1/ 26/95.

32 The Chicago Tribune, 1/26/95

33 A.S. Gray, Canadian Dental Association Journal, October 1987, pp. 76-83.

34 Letter, Sierra Club to Wm. K. Reilly, EPA, 7/21/89.

35 John Yiamouyiannis, Fluoride, 1990, Vol. 23, pp. 55-67.

36 J.A. Brunelle and J.P. Carlos, "Recent Trends in Dental Caries in U.S. Children and the Effect of Water Fluoridation," JOURNAL OFDENTAL RESEARCH Vol. 69, Special Issue (February 1990), pgs. 723-727 and discussion pgs. 820-823.

37 Center for Health Action, 3/30/90.

38 Clinical Pediatrics, Nov. 1991.

39 ADA News, 10/17/94.

40 Angelillo IF, Torre I, Nobile CG, Villari P. Caries and fluorosis prevalence in communities with different concentrations of fluoride in the water. Caries Res 1999;33(2):114-22

41 The Science and Practice of Caries Prevention. Featherstone, J.D.B. Journal of the American Dental Association 2001 131, 887-899.

42 Seppa L, Karkkainen S, Hausen H. Caries trends 1992-1998 in two low-fluoride Finnish towns formerly with and without fluoridation. Caries Res 2000 Nov-Dec;34(6):462-8.

43 Maupome G, Clark DC, Levy SM, Berkowitz J. Patterns of dental caries following the cessation of water fluoridation. Community Dent Oral Epidemiol 2001 Feb;29(1):37-47

44 Kunzel W, Fischer T. Caries prevalence after cessation of water fluoridation in La Salud, Cuba. Caries Res 2000 Jan-Feb;34(1):20-5

45 de Liefde B. The decline of caries in New Zealand over the past 40 years.N Z Dent J 1998 Sep;94(417):109-13

46 Kunzel W, Fischer T, Lorenz R, Bruhmann S. Decline of caries prevalence after the cessation of water fluoridation in the former East Germany. Community Dent Oral Epidemiol 2000 Oct;28(5):382-9

47 Kumar JV, Swango PA. Community Dent Oral Epidemiol 1999 Jun;27(3):171-80

48 Chemical and Engineering News, 8/1/88, p.31.

49 Limeback H. A re-examination of the pre-eruptive and post-eruptive mechanism of the anti-caries effects of fluoride: is there any anti-caries benefit from swallowing fluoride? Community Dent Oral Epidemiol 1999 Feb;27(1):62-71

50 Gary Null interview with Dr. Harvey Limeback, 1/30/01.

51 Gary Null interview.

52 Keith E. Heller and others, "Dental Caries and Dental Fluorosis at Varying Water Fluoride Concentrations," JOURNAL OF PUBLIC HEALTH DENTISTRY Vol. 57, No. 3 (Summer 1997), pgs. 136-143.

53 John Colquhoun. Why I Changed My Mind About Water Fluoridation.Perspectives in Biology and Medicine, 41, 1, Autumn 1997

54 Waldbott, op. cit., p. xvii.

56 Statement by Dr. James Patrick before Congressional Subcommittee, 8/4/82.

57 Journal of the Canadian Dental Association, Vol. 59, Apr. 1993, p. 334.

58 Gary Null interview with Dr. John Lee, 3/10/95.

59 Ibid.

60 Roholm K. Fluorine Intoxication. A Clinical-Hygienic Study. Nyt Nordisk, Copenhagen and H K Lewis, London 1937 pp 281-282.

61 Health Effects of Ingested Fluoride. National Academy of Sciences, USA 1993: p 59.

62 F. Exner and G. Waldbott, The American fluoridation

63 Federal Register, 12/24/75.

64 See http://www.fluoridealert.com/

65 Pierre-M. Galletti and Gustave Joyet, "Effect of fluorine on thyroidal iodine metabolism in hyperthyroidism," JOURNAL OF CLINICAL ENDOCRINOLOGY Vol. 18 (October 1958), pgs. 1102-1110.

66 Beth Ann Ditkoff and Paul Lo Gerfo, THE THYROID GUIDE [ISBN 0060952601] (New York: Harper, 2000), cover notes.

67 HIP FRACTURES & FLUORIDE REVISITED: A CRITIQUE. Fluoride Vol. 33 No. 1 1-5 2000 Editorial 1.

68 Chemical and Engineering News, 8/1/88, p. 33.

69 Jan G. Stannard et al., "Fluoride levels and fluoride contamination of fruit juices," The Journal of Clinical Pediatric Dentistry, Vol. 16, No. 1, 1991, pp. 38-40.

70 Gary Null interview.

71 Heilman, et al., JADA, July 1997.

72 Ibid.

73 ibid.

74 Bardsen A, Bjorvatn K. Risk periods in the development of dental fluorosis. Clin Oral Investig 1998 Dec;2(4):155-60

75 Mascarenhas, Ana Karina. Risk factors for Dental Fluorosis: A review of the recent literature. Pediatric Dentistry, 4/22/2000.

76 Pereira AC, Da Cunha FL, Meneghim M de C, Werner CW. Dental caries and fluorosis prevalence study in a nonfluoridated Brazilian community: trend analysis and toothpaste association. Fluoride 33 (2) 2000.

77 Institute of Medicine (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board. National Academy Press, Washington, DC. Cited in "50 Reasons to Oppose Fluoridation."

78 Rwenyonyi CM, Birkeland JM, Haugejorden O, Bjorvatn K. Age as a determinant of severity of dental fluorosis in children residing in areas with 0.5 and 2.5 mg fluoride per liter in drinking water. Clin Oral Investig 2000 Sep;4(3):157-61

79 Waldbott, op. cit., pp. 307-308.

80 Gary Null interview.

81 Gary Null interview with Dr. John Lee, 3/10/95.

82 Schenectady Gazette Star, 8/5/89.

83 Daniel Grossman, "Fluoride's Revenge," The Progressive, Dec. 1990, pp. 29-31.

84 American Journal of Public Health, 12/85.

85 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

86 Daniel Grossman. Op. cit..

87 George Glasser, "Dental Fluorosis - A Legal Time Bomb!" Sarasota/Florida ECO Report, Vol. 5, No. 2, Feb. 1995, pp. 1-5.

88 New York Times, Sunday, Junje 10, 2001.

89 Chemical and Engineering News, 8/1/88, p. 49.

90 New York State Coalition Opposed to Fluoridation, release, 11/89.

91 Gary Null interview with Dr. John Yiamouyiannis 4/28/90.

92 Chemical and Engineering News, 8/1/88, p. 36.

93 Hileman, Bette. Fluoridation of Water. Questions about Health Risks and Benefits Remain After 40 Years. Chemical & Engineering News Vol. 66 (August 1, 1988.

94 Connett P. 50 Reasons to Oppose Fluoridation.

95 Gary Null interview.

96 Waldbott, op. cit., p. 38.

97 F. Exner and G. Waldbott, op. cit., pp. 42-43.

98 JAMA, Vol. 264, July 25, 1990, pp. 500.

99 Cooper et al., JAMA, Vol. 266, July 24, 1991, pp. 513-14.

100 Christa Danielson et al., "Hip fractures and fluoridation in Utah's elderly population," JAMA, Vol. 268, Aug. 12, 1992, pp. 746-48.

101 Ibid., p. 746.

102 New England Journal of Medicine, Vol. 322, pp. 802-809.

103 Journal of Bone and Mineral Research, 11/94.

104 U.S. National Research Council, Diet and Health, Washington, D.C., National Academy Press, 1989, p. 121.

105 Hip Fractures And Fluoride Revisited: A Critique. Fluoride Vol. 33 No. 1 1-5 2000 Editorial 1.

106 Ibid.

107 U.S. National Research Council, Diet and Health,Washington, D.C., National Academy Press, 1989, p. 121.

108 Waldbott GL, Burgstahler A, McKinney HL. Fluoridation: The Great Dilemma. Coronado Press Inc, Kansas, 1978. pp81-4.

109 50 reasons to oppose fluoridation.

110 National Cancer Institute (1989). Cancer Statistics Review, 1973-1987, Bethesda, MD: National Institutes of Health. Publication No.90-2789.

111 Cohn, P.D. (1992). An Epidemiologic Report on Drinking Water and Fluoridation. New Jersey Department of Health, Trenton, NJ.

112 Albright JA. The effect of fluoride on the mechanical properties of bone. Transactions of the Annual Meeting of the Orthopedics Research Society. 1978; 240 (15): 1630-1.

113 Robin JC, et al. Studies on osteoporosis III. Effect of estrogens and fluoride. J Med. 1980; II (1): 1-14

114 Danielson C, et al. Hip fractures and fluoridation in Utah's elderly. JAMA 1992; 268: 746-8.

115 Kleerekoper M. Fluoride and the skeleton. Crit Rev Clin Lab Sci 1996 Apr;33(2):139-61

116 Dequeker J, Declerck K. Schweiz Med Wochenschr 1993 Nov 27;123(47):2228-34 Fluor in the treatment of osteoporosis. An overview of thirty years clinical research.

117 L.R. Hedlund and J.C. Gallagher, "Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride," JOURNAL OF BONE MINERAL RESEARCH Vol. 4, No. 2 (April 1989), pgs. 223-225.

118 B.L. Riggs and others, "Effect of fluoride treatment on the fracture rates in postmenopausal women with osteoporosis," NEW ENGLAND JOURNAL OF MEDICINE Vol. 322, No. 12 (March 22 1990), pgs. 802-809.

119 Kotha SP, Walsh WR, Pan Y, Guzelsu N. Varying the mechanical properties of bone tissue by changing the amount of its structurally effective bone mineral content. Biomed Mater Eng 1998;8(5-6):321-34

120 Colquhoun. Op. Cit.

121 See Connett P. 50 Reasons to Oppose Fluoridation.

122 Li, Y., C. Liang, et al. (1999). "Effect of Long-Term Exposure to Fluoride in Drinking Water on Risks of Bone Fractures." Submitted for publication. Contact details: Dr. Yiming Li, Loma Linda School of Dentistry, Loma Linda, California, Phone 1-909-558-8069, Fax 1-909-558-0328 and e-mail, Yli@sd.llu.edu.

123 "Middletown, Maryland latest city to receive toxic spill of fluoride in their drinking water," report by Truth About Fluoride, Inc., in Townsend Letter for Doctors, 10/15/94, p. 1124.

124 "Middletown, Maryland latest city to receive toxic spill of fluoride in their drinking water," report by Truth About Fluoride, Inc., in Townsend Letter for Doctors, 10/15/94, p. 1124.

125 Reprinted by M. Bevis, "Morbidity associated with ingestion/dialysis of community water fluoride," CDC, Dental Div., 6/11/92, distributed by Safe Water Foundation of Texas.

126 . Townsend Letter for Doctors, 10/94, p. 1125.

127 Janet Raloff, "The St. Regis Syndrome," Science News, July 19, 1980, pp. 42-43; reprinted in Griffiths, op. cit., p. 26.

128 Robert Tomalin, "Dumping grounds," Wall Street Journal, Nov. 29, 1990; reprinted in Griffiths, op. cit.

129 "Summary review of health effects associated with hydrogen fluoride acid related compounds," EPA Report Number 600/8-29/002F, Dec. 1988, pp. 1- .

130 John Yiamouyiannis, Lifesaver's Guide to Fluoridation, Delaware, Ohio, Safe Water Foundation, 1983, p. 1.

131 G.L. Waldbott et al., Fluoridation: The Great Dilemma, Lawrence, KS, Coronado Press, 1978, p. 222.

132 Ibid.

133 Graham, JR and Morin PJ.Highlights of North American Litigation During the Twentieth Century on Fluoridation of Public Water Supplies. Journalof Land Use and Environmental Law.

134 Ibid.

135 Hilleboe HE, et al. Newburgh-Kingston Caries Fluorine Study: Final Report, 52. JADA 290 (1956).

136 Harris RR. Dental Science in a New Age, Hisotry of the National institute of Dental Research (1989)

137 ibid.

138 Graham and Morin. Op. Cit.

139 John Yiamouyiannis and Dean Burk, "Fluoridation of public water systems and cancer death rates in humans," presented at the 57th annual meeting of the American Society of Biological Chemists,and published in Fluoride, Vol. 10, No. 3, 1977, pp. 102-103.

140 National Institute of Dental Research, "Fluoridation of water and cancer: a review of the epidemiological efficiency," 1985, pp. 10-13.

141 New York State Coalition Opposed to Fluoridation.

142 Newsday, 2/27/90.

143 Oakland Tribune, 2/16/90.

144 NFFE Local 2050, 3/90.

145 Washington Post, 2/20/90.

146 The Lancet, 2/3/90.

147 Gary Null interview with Dr. John Yiamouyiannis 4/28/90.

148 Center for Health Action.

149 M.W. Browne, The New York Times, 3/13/90.

150 Ibid.

151 Medical Tribune, 2/22/90.

152 New York State Medical News, 3/90.

153 S. Begley, Newsweek, 2/5/90.

154 Safe Water Foundation, 3/4/90

155 Mutation Research, Vol. 223, pp. 191-203.

156 Joel Griffiths, Medical Tribune, 2/22/90.

157 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

158 Environmental and Molecular Mutagenesis, Vol. 21, pp. 309-318.

159 Journal of Carcinogenesis, Vol. 9, pp. 2279-2284.

161 Mark Lowey, "Scientists question health risks of fluoride," Calgary Herald, Calgary, Alberta, Canada, Feb. 28, 1992;

162 Griffiths, op. cit., p. 66.

163 Connett. 50 Reasons to Oppose Fluoridation.

164 Ibid.

165 Masters RD, Coplan MJ, Hone BT, Dykes JE. Association of silicofluoride treated water with elevated blood lead. Neurotoxicology 2000 Dec;21(6):1091-100

166 Trustees of Dartmouth College. Dartmouth Researcher Warns of Chemicals Added to Drinking Water. 15 March 2001. www.dartmouth.edu/~news

167 ibid.

168 ibid.

169 ibid.

170 Journal of Dental Research, Vol. 55, Sup B, p. 523, 1976, "Effect of Inorganic Fluoride Salts on Urine and Tissue Cyclic AMP Concentration in Vivo".

171 Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ. Neurotoxicity of sodium fluoride in rats. Neurotoxicol Teratol 1995 Mar-Apr;17(2):169-77

172 Ekambaram P, Paul V. Environ. Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats.Toxicol. Pharmacol. 2001 Mar;9(4):141-146

173 Varner JA, Jensen KF, Horvath W, Isaacson RL. Brain Res 1998 Feb 16;784(1-2):284-98 Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity.

174 Ibid.

175 Strunecka A, Patocka J. Reassessment of the role of aluminum in the development of Alzheimer's disease. Cesk Fysiol 1999 Feb;48(1):9-15

176 Gary Null interview with Paul Connett, Ph.D.

177 Strunecka A and Patocka J. Pharmacological and toxicological effects of aluminofluoride complexes. Fluoride, vol. 32, No. 4 (November 1999).

178 Ibid.

179 ibid.

180 Luke JA. The Effect of Fluoride on the Physiology of the Pineal Gland.

181 Ibid.

182 National Sleep Foundation. Sleep in America poll. 2001.

183 Luboshitzky R, Lavie P. Melatonin and sex hormone interrelationships--a review. J Pediatr Endocrinol Metab 1999 May-Jun;12(3):355-62

184 Genazzani AR, Bernardi F, Monteleone P, Luisi S, Luisi M. Neuropeptides, neurotransmitters, neurosteroids, and the onset of puberty. Ann N Y Acad Sci 2000;900:1-9

185 Okasha M, McCarron P, McEwen J, Smith GD. Age at menarche: secular trends and association with adult anthropometric measures. Ann Hum Biol 2001 Jan-Feb;28(1):68-78

186 Adair LS, Gordon-Larsen P. Maturational timing and overweight prevalence in US adolescent girls. Am J Public Health 2001 Apr;91(4):642-4

187 Foulkes R. The Fluoride Connection: Fluoride and the Placental Barrier. Townsend Letter for Doctors and Patients. Issue #177.

188 Cox WR. Hello Test Animals or You and Your Grandchildren. Olsen Publishing Co., Milwaukee, WI 1951. Cited in Foulkes, op. cit.

189 Ibid.

190 ibid.

191 ibid.

192 Freni SC. Exposure to high fluoride concentrations in drinking water is associated with decreased birth rates. J Toxicol Environ Health 1994 May;42(1):109-21

193 Foulkes. Op. Cit.

194 Narayana MV and Chinoy NJ. Effects of fluoride on rat testicular steroidogenesis. Fluoride, 27; 1; 7-12, 1994.

195 Chinoy NJ, Narayana MV. In vitro fluoride toxicity in human spermatozoa. Reprod Toxicol 1994 Mar-Apr;8(2):155-9.

196 Li XS et al. Effect of fluoride exposure in intelligence in children. Fluoride 1995; 28 (4).

197 Yang Y, Wang X, Guo X. Effects of high iodine and high fluorine on children's intelligence and the metabolism of iodine and fluorine. Zhonghua Liu Xing Bing Xue Za Zhi 1994 Oct;15(5):296-8

198 Shettler T, et al. In Harm's Way: Toxic Threats to Child Development. (Cambridge MA: Greater Boston Physicians for Social Responsibility, May 2000).

199 Gary Null interview.

200Gary Null interview with Dr. Paul Connett, 1/30/01.

201 Klein W et al. DNA repair and environmental substances. Zeitschrift fur Angewandte Bader-und Klimaheilkunde, 1977; 24 (3).

202 Mohamed A, Chandler ME. Cytological effects of sodium fluoride on mice. Fluoride. 1982; 15 (3): 110-18

203 Jachimczak D, Skotarczak B. The effect of fluorine and lead ions on the chromosomes of human leucocytes in vitro. Genetica Polonica . 1978; 19 (3): 353-7

204 Mukerjee RN, Sobels FH. The effect of sodium fluoride and idoacetamide on mutation induction by X-irradiation in mature spermatozoa of drosophila.

205 Jagiello G, Lin J-S. Sodium fluoride as potential mutagen in mammalian eggs. Arch Environ Hlth . 1974; 29: 230-5.

206 Yiamouyiannis JA, Burk D. Fluoridation of public water systems and the cancer death rate in humans. Presented at the 67th Annual Meeting of the American Society of Biologists and Chemists and the American Society of Experimental Biologists. June 1976.

207 Center for Health Action, 3/90.

208 Gary Null interview with Dr. William Marcus, 3/10/95.

209 ibid.

210 ibid.

211 ibid.

212 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

213 Gary Null interview with Dr. John Lee, 3/10/95.

214 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

215 Ibid.

216 Gary Null interview with Dr. William Marcus, 3/10/95.

217 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

218 Hirzy. Op. cit.

219 Ibid.

220 ibid.

221 ibid.

222 ibid.

223 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

224 New York State Coalition Opposed to Fluoridation.

225 Longevity Magazine, 7/89.

226 Gary Null interview with Dr. John Lee, 3/10/95.

227 Should Natick Fluoridate? A Report to the Town and the Board of Selectmen Prepared by the Natick Fluoridation Study Committee 13 E. Central Street, Town of Natick, MA October 23, 1997

228 Arkansas Democrat-Gazette, June 13, 2001.

229 http://www.fluoridealert.org

230 Gary Null interview with Dr. John Yiamouyiannis, 3/10/95.

231 Ibid.

232 The Morning Call, 2/7/90

233 The New York Times, 3/13/90.

Fluoride in your water

2007-12-07T13:25:00.001-08:00

Fluoridation / Fluoride
Toxic Chemicals In Your Water

Note: For more information on health-building techniques, please see the Holistic Healing Web Page.

Fluoride compounds which are put in water (fluoridation), toothpaste and supplement tablets (including some vitamins) were never tested for safety before approval. Recent independent research by scientists not associated with dental trade organizations has shown the following:

Neurotoxic and Lowers IQ
In 1995, neurotoxicologist and former Director of toxicology at Forsyth Dental Center in Boston, Dr. Phyllis Mullenix published research showing that fluoride built up in the brains of animals when exposed to moderate levels. Damage to the brain occured and the behavior patterns of the animals was adversely effected. Offspring of pregnant animals receiving relatively low doses of fluoride showed permanent effects to the brain which were seen as hyperactivity (ADD-like symptoms). Young animals and adult animals given fluoride experienced the opposite effect -- hypoactivity or sluggishness. The toxic effects of fluoride on the central nervous system was subsequently confirmed by previously-classified government research. Two new epidemiological studies which tend to confirm fluoride's neurotoxic effects on the brain have shown that children exposed to higher levels of fluoride had lower IQs.

A study published in Brain Research shows that rats drinking only 1 part per million fluoride (NaF) in water had histologic lesions in their brain similar to Alzheimer's disease and dementia. In addition, evidence was seen pointing to possible damage to the blood brain barrier from extended fluoride exposure. This study was the third in a series of papers published by Varner et al. Brain Research Vol. 784 No. 12 p 284-298 (1998). Results of this recent study and other studies showing significant dangers from low-level fluoride exposure were presented at a recent scientific symposium.

Causes Cancer
The Department of Health in New Jersey found that bone cancer in male children was between two and seven times greater in areas where water was fluoridated. U.S. Environmental Protection Agency (EPA) researchers confirmed the bone cancer-causing effects of fluoride at low levels in an animal model. A new study has shown that fluoridation of water is linked to uterine cancer deaths.

Changes Bone Structure and Strength
Fluoride gradually builds up in the bones and causes adverse changes to the bone structure. Quite a few studies have shown that fluoridation leads to increases in hip fractures. The tensile strength of the hip is destroyed over time by fluoride ingestion.

Causes Birth Defects and Perinatal Deaths
A toxicologist in the United Kingdom recently found that perinatal deaths in a fluoridated area was 15% higher than in neighboring non-fluoridated areas. The fluoridated area had a higher socio-economic status and would have been expected to have less perinatal deaths. The fluoridated area also had a 30% higher rate of Down's Syndrome. Chile banned fluoridation because of research by the world-reknowned researcher, Dr Albert Schatz, which showed a link to infant deaths due to fluoridation.

Proven Ineffective
Fluoride compounds in water and in supplements do not provide any significant cavity-protecting effects. All of the recent large-scale studies of water fluoridation have shown that there are no positive effects. That is why countries without fluoridation have shown an equal improvement in dental health as those with fluoridation. (See Research Item #5.) There is scientific evidence that excessive fluoride exposure leads to increased levels of caries. Even pro-fluoridation scientists admit that there is not any properly-conducted research showing that fluoride supplements help prevent cavities. (Note: check vitamins carefully to be sure they do not include fluoride.)

Impairs Immune System
Independent research has shown that fluoride impairs the functioning of the immune system. In the United States, where toxic fluoride compounds are regularly added to water and given to children since the 1960s and 1970s, we are beginning to see an overwhelming number of people of that generation who are developing chronic immune system disorders.

Causes Acute Adverse Reactions
Several double-blind studies have shown that fluoridated water can often cause acute adverse reactions (in addition to the chronic poisoning effects discussed below). Some of the effects seen in double-blind studies include: gastrointestinal symptoms, stomatitis, joint pains, polydipsia, headaches, visual disturbances, muscular weakness, and extreme tiredness. An enlightening review of a book by one famous and well-respected researcher from The Netherlands who found adverse reactions in double-blind experiments can be read here.

Causes Initial Stages of Skeletal Fluorosis
Fluoride can cause severe skeletal fluorosis at high levels. Chronic, long-term exposure to levels of fluoride commonly found in water and food in the U.S. can cause the beginning stages of skeletal fluorosis including: pains in bones and joints, sensations of burning, pricking, and tingling in the limbs, muscle weakness, chronic fatigue, gastrointestinal disorders, reduced appetite, backache, osteoarthritis, etc. In fact, decades of ingestion of fluoride from water and other common sources can be expected to cause these symptoms in large numbers of people based on calculations of fluoride intake and excretion. (Keep in mind that fluoride is a cumulative poison since it builds up in the body of years.) Very few healthcare practitioners are capable of diagnosing such a condition because healthcare practitioners are not trained to test for or recognize the effects chronic poisoning from fluoride.

Increases Lead and Arsenic Exposure
Fluoride compounds put into water are often contaminated with lead, arsenic and radio nuclides since the fluoride compounds are toxic waste byproducts which largely come from pollution scrubbers of fertilizer plants. A study published in 2000 showed that the dumping of toxic silicofluoride compounds into water ("fluoridation") causes an increase in blood lead levels in children.

Fluoride Causes Osteoarthritis
In a study published in Rhuematology International in 2001, researchers found a link between fluoride exposure and the development of osteoarthritis. The level of exposure that caused osteoarthritis is common in the United States.

Contributes to the Development of Repetitive Stress Injury
A clinical study in New Zealand showed that fluoride ingestion may be a contributing factor in the development of Repetative Stress Injury (RSI) since such ingestion may encourage the development of apatite crystal formation. Elimination of fluoride plus regular supplementation of magnesium appeared to help RSI patients considerably.

Causes Permanent Disfigurement of the Teeth in Many Children
A very large and increasing number of children are experiencing dental fluorosis which is a permanent adverse structural change to the teeth.

Inhibits Key Enzymes
As fluoride builds up in different parts of the body over decades it can disrupt the actions of many key enzymes. This fact has been known for a long time.

Supresses Thyroid Function
Fluoride was given at low levels during the early to mid 20th century as an effective way of supressing thyroid function and treating hyperthyroidism. Articles and research can be found on the Thyroid web page.

Causes Large Numbers of Acute Poisonings
Fluoride is an extremely poisonous substances at exceptionally low doses and has caused a large number of acute poisonings. This is why a poison warning is now required on fluoridated toothpastes sold in the U.S.

Independent Experts Oppose Dumping Fluoride Into Water
Over 1500 professionals at the US EPA, including toxicologists and risk assessment experts voted unanimously to oppose the fluoridation initiative in California because of the health risks involved. See summary or official EPA union statement. Even the Candian Dental Association Consultant and Researcher urged people to avoid drinking fluoridated water.

Unethical
Fluoridation amounts to forced medication of the water supply. Such practices demonstrate a complete lack of ethics on the part of its promoters. Studies as early the 1930s showed extreme hazards to man and the environment due to fluoride dumping and exposure. Companies and organizations involved used the promotion of "fluoridation" as a way to avoid lawsuits due to dumping toxic wastes and later for economic gain. Please read the short history of fluoridation for more detailed information.

Banned in Many Countries
Fluoridation is not legal or not used in the overwhelming number of countries including industrialized countries. Please see Fluoride Status of Countries web page.

Many independent researchers, organizations, holistic healthcare experts and a growing number of dentists who avoid the use of toxic substances are warning their patients to avoid fluoridated water and fluoridated toothpaste and to definately not give children any fluoride since they appear to be more susceptible to the neurological toxicity from fluoride.

If your water department adds toxic fluoride compounds to the water, the best course of action is usually to drink and cook with bottled "spring" water. Carbon filters do not remove fluoride compounds to any significant extent. Avoid putting fluoridated water in humidifiers. Many non-organic juices have large amounts of fluoride from pesticide residues. It is best to juice your own vegetables and fruits from organic produce or go to a health food store to purchase organic juices.

Avoid toothpastes that have fluoride even if the manufacturers claim that the fluoride came from "natural" sources. Even though topical fluoride treatment may have an effect to help remineralize cavities at the early stages, the combination of a healthy diet, proper dental hygiene and saliva can have a similar effect. It is impossible to avoid swallowing some fluoride from fluoridated toothpaste. I have tried various toothpastes and current use the natural Weleda toothpaste with baking soda. I like that fact that it does not contain fluoride or the detergent, sodium lauryl sulfate (SLS).

More detailed information about fluoride and proper dental care:

Fluoridation Does Not Prevent Tooth Decay

Fluoride: Detailed General & Scientific Information

Fluoride: Journal of the International Society for Fluoride Research

Parents of Fluoride Poisoned Children: Main Page / Toxicological Profile / Thyroid Page

International Academy of Oral Medicine & Toxicology Position Paper on Fluoridation (Click on Download Article)

Scientific Statement Signed By 1,500+ U.S. Environmental Protection Agency Scientists and Professionals

NoFluoride.com (Statements by Scientific and Medical Experts)

Fluoride Action Network

Fluoride Issues Web Page

Fluorides & Fluoridation: Evidence Based on Science?

Citizens for Safe Drinking Water

Fluoride: The Deadly Legacy by Gary Null

Book Review: The Fluoride Deception

History of Fluorine, Fluoride and Fluoridation

Article & Resources for Eliminating Dental Disease

Alternatives to Fluoridated Water

Preventive Dental Association

Dental Fluorosis Prevention Program

Back to Holistic Healing Home Page

Fluoride & the Brain:

2007-12-07T12:14:00.000-08:00

HEALTH EFFECTS: Fluoride & the Brain

DIRECTORY: FAN > Health > Brain

Key Findings - Fluoride & the Brain: (Click for more detail)

1) Fluoride's ability to damage the brain represents one of the most active areas of research on fluoride toxicity today.

2) The research on fluoride and the brain has been fueled by recent human studies from China finding elevated levels of fluoride exposure to be associated with reduced cognitive ability (e.g. reduced I.Q.) in children.

3) The impact of fluoride on children's IQ has been documented even after controlling for children's lead exposure, iodine exposure, parental education and income status, and other known factors that might impact the results (Xiang 2003 a,b).

4) A recent UNICEF-sponsored study reported that in areas of China with endemic iodine deficiency, fluoride exposure during childhood significantly exacerbated the neurological deficits produded by iodine deficiency.

5) The findings of neurological effects in fluoride-exposed humans is consistent with, and strengthened by, recent findings from over 30 animal studies published since 1992. As with the studies on humans, the studies on animals have reported an impairment in learning and memory prorcesses among the fluoride-treated groups.

6) The animal studies have also documented considerable evidence of direct toxic effects of fluoride on brain tissue, even at levels as low as 1 ppm fluoride in water (Varner 1998). These effects include:

-- reduction in nicotinic acetylcholine receptors;
-- reduction in lipid content;
-- impaired anti-oxidant defense systems;
-- damage to the hippocampus;
-- damage to the purkinje cells;
-- increased uptake of aluminum;
-- formation of beta-amyloid plaques (the classic brain abnormality in Alzheimer's disease);
-- exacerbation of lesions induced by iodine deficiency; and
-- accumulation of fluoride in the pineal gland.

Articles of Interest - Fluoride & the Brain: (back to top)

Excerpts from NRC Report - FAN, March 28, 2006
Yet more research on fluoride and the brain - FAN Science Watch June 25, 2004
Fluoride's effects on the brain - Ellen Connett, Director, Fluoride Action Network Pesticide Project, April 19, 2004
Fluoride Linked to Low IQ, Studies Show - Fluoride Action Network August 25, 2003
In Harm's Way: Toxic Threats to Child Development Greater Boston Physicians for Social Responsibility May 2000
On the Neurotoxicity of Fluoride Phyllis Mullenix, Ph.D., September 14, 1998
Fluoride & The Brain: An Interview with Dr. Phyllis Mullenix Interview by Paul Connett, PhD, October 18, 1997
Fluoride & the Pineal Gland IFIN Bulletin, March 2001
Rat Studies Link Brain Cell Damage With Aluminum and Fluoride in Water Wall Street Journal October 28, 1992

Available Full-Text Papers Online - Fluoride & the Brain: (back to top)

FULL-TEXT (pdf): Xiang Q, et al. (2003). Effect of fluoride in drinking water on children's intelligence. Fluoride 36: 84-94.

FULL-TEXT (pdf): Lu Y, et al (2000). Effect of high-fluoride water on intelligence of children. Fluoride 33:74-78.

FULL-TEXT (pdf): Varner JA, et al. (1998). Chronic administration of aluminum-fluoride and sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Research 784: 284-298.

FULL-TEXT (pdf): Mullenix P, et al. (1995).Neurotoxicity of sodium fluoride in rats. Neurotoxicology and Teratology 17:169-177.

FULL-TEXT (html): Lin Fa-Fu; et al (1991). The relationship of a low-iodine and high-fluoride environment to subclinical cretinism in Xinjiang. Iodine Deficiency Disorder Newsletter Vol. 7. No. 3. (August).

NOTABLE QUOTES- Fluoride's Impact on the Brain: (back to top)

"it is apparent that fluorides have the ability to interfere with the functions of the brain."
SOURCE: National Research Council. (2006). Fluoride in Drinking W ater: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p 187.

"Studies in animals and human populations suggest that fluoride exposure, at levels that are experienced by a significant proportion of the population whose drinking water is fluoridated, may have adverse impacts on the developing brain. Though no final conclusions may be reached from available data, the findings are provocative and of significant public health concern."
SOURCE: Schettler T, et al. (2000). Known and suspected developmental neurotoxicants. pp. 90-92. In: In Harms Way - Toxic Threats to Child Development. Greater Boston Physicians for Social Responsibility: Cambridge, MA. (See report)

“Fluorides also increase the production of free radicals in the brain through several different biological pathways. These changes have a bearing on the possibility that fluorides act to increase the risk of developing Alzheimer’s disease.”
SOURCE: National Research Council. (2006). Fluoride in Drinking W ater: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p 186.

“Studies of populations exposed to different concentrations of fluoride should be undertaken to evaluate neurochemical changes that may be associated with dementia. Consideration should be given to assessing effects from chronic exposure, effects that might be delayed or occur late-in-life, and individual susceptibility.”
SOURCE: National Research Council. (2006). Fluoride in Drinking W ater: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p 187.

HUMAN STUDIES- Fluoride's Impact on the Brain: (back to top)

"A few epidemiologic studies of Chinese populations have reported IQ deficits in children exposed to fluoride at 2.5 to 4 mg/L in drinking water. Although the studies lacked sufficient detail for the committee to fully assess their quality and relevance to U.S. populations, the consistency of the results appears significant enough to warrant additional research on the effects of fluoride on intelligence."
SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p. 6.

"This study investigated the effects of arsenism and fluorosis on the mental ability (MA) and growth of children living in areas endemic for arsenism, fluorosis , or both... The MA [mental ability] score was negatively correlated with urinary arsenic (P<0.01)>
SOURCE: Wang S, et al. (2005). Investigation and evaluation on intelligence and growth of children in endemic fluorosis and arsenism areas. Chinese Journal of Endemiology 24:179-182.

“Higher drinking water fluoride levels were significantly associated with higher rates of mental retardation (IQ <70)> In endemic fluorosis areas, drinking water fluoride levels greater than 1.0 mg/L may adversely affect the development of children's intelligence.”
SOURCE: Xiang Q, et al. (2003a). Effect of fluoride in drinking water on children's intelligence. Fluoride 36: 84-94.

"As an additional part of our investigation of an association between fluoride in drinking water and children’s intelligence in two villages of Sihong County, Jiangsu Province, China, we have now determined blood lead levels of children in that study... The results show there is essentially no difference between the two villages in blood lead concentrations of the children... These results thus make it very unlikely that the differences in IQ of the children living in Wamiao and Xinhuai are the result of differences in exposure to lead rather than to fluoride."
SOURCE: Xiang Q, et al. (2003b). Blood lead of children in Wamiao-Xinhuai intelligence study. Fluoride 36: 198-199.

“After controlling by significant confounders, urinary fluoride correlated positively with reaction time and inversely with the scores in visuospatial organization. IQ scores were not influenced by fluoride exposure. An increase in reaction time could affect the attention process, also the low scores in visuospatial organization could be affecting the reading and writing abilities in these children.”
SOURCE: Calderon J, et al. (2000). Influence of fluoride exposure on reaction time and visuospatial organization in children. Epidemiology 11(4): S153.

“The IQ of the 60 children in the high-fluoride area was significantly lower than that of the 58 children in the low-fluoride area... More children in the high-fluoride area were in the retardation or borderline categories of IQ than children in the low fluoride area. An inverse relationship was also present between IQ and the urinary fluoride level. Exposure of children to high levels of fluoride may therefore carry the risk of impaired development of intelligence.”
SOURCE: Lu Y, et al (2000). Effect of high-fluoride water on intelligence of children. Fluoride 33:74-78.

“Sulfuryl fluoride exposure over the year preceding examination was associated with significantly reduced performance on the Pattern Memory Test and on olfactory testing... CONCLUSIONS: Occupational sulfuryl fluoride exposures may be associated with subclinical effects on the central nervous system, including effects on olfactory and some cognitive functions.”
SOURCE: Calvert GM, et al. (1998). Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers. American Journal of Public Health 88:1774-80.

"A study of intelligence quotient (IQ) in China was conducted using Wickler's Intelligence Quotient Table for preschool children, in 4-7 year-old children, 147 from a district with high level of fluoride and 83 from a control area. High F intake had a significant influence on IQ of preschool children. Operation IQ was mainly affected."
SOURCE: Wang G, et al. (1996). Research on intelligence quotient of 4-7 year-old children in a district with a high level of fluoride. Endemic Diseases Bulletin 11:60-62.

“In Shanxi Province, China, children living in the endemic fluoride village of Sima located near Xiaoyi City had average IQ significantly lower than children living to the north in the nonendemic village of Xinghua.”
SOURCE: Zhao LB, et al (1996). Effect of high-fluoride water supply on children's intelligence. Fluoride 29: 190-192.

“The intelligence was measured of 907 children aged 8-13 years living in areas which differed in the amount of fluoride present in the environment. The Intelligence Quotient (IQ) of children living in areas with a medium or severe prevalence of fluorosis was lower than that of children living in areas with only slight fluorosis or no fluorosis. The development of intelligence appeared to be adversely affected by fluoride in the areas with a medium or severe prevalence of fluorosis. A high fluoride intake was associated with a lower intelligence.”
SOURCE: Li XS. (1995). Effect of Fluoride Exposure on Intelligence in Children. Fluoride 28:189-192.

“We made an investigation in 157 children, aged 12-13, born and grew up in a coal burning pattern endemic fluorosis area and an experiment on excessive fluoride intake in rat. The results showed: (1) Excessive fluoride intake since early childhood would reduce mental work capacity (MWC) and hair zinc content: (2) The effect on zinc metabolism was a mechanism of influence on MWC by excessive fluoride intake...”
SOURCE: Li Y, et al. (1994). [Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism] Hua Hsi I Ko Ta Hsueh Hsueh Pao. 25:188-91.

"Although the blood-brain barrier is relatively impermeable to fluoride, it does not pose an absolute barrier and fluoride has the ability to enter the brain. The literature was examined to assess the quality of the evidence for cerebral impairment occurring due to exposure to fluoride from therapeutic or environmental sources. Several surveys of persons chronically exposed to industrial fluoride pollution reported symptoms related to impaired central nervous system functioning with impaired cognition and memory. Examination of individual case reports showed the evidence for aetiological relationships between symptoms and fluoride exposure to be of variable quality. The evidence was seen as being suggestive of a relationship rather than being definitive. The difficulties with concentration and memory described in relation to exposure to fluoride did not occur in isolation but were accompanied by other symptoms of which general malaise and fatigue were central. Possible mechanisms whereby fluoride could affect brain function include influencing calcium currents, altering enzyme configuration by forming strong hydrogen bonds with amide groups, inhibiting cortical adenylyl cyclase activity and increasing phosphoinositide hydrolysis."
SOURCE: Spittle B. (1994). Psychopharmacology of fluoride: a review. International clinical psychopharmacology 9:79-82.

“Fifteen therapeutically aborted fetuses at the 5th-8th gestation month from the endemic fluorosis area were compared with those from the non-endemic area. Stereological study of the brains showed that the numerical density of volume of the neurons and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were increased. The mean volume of the neurons was reduced. The numerical density of volume, the volume density and the surface density of the mitochondria were significantly reduced. The results showed that chronic fluorosis in the course of intrauterine fetal life may produce certain harmful effects on the developing brain of the fetus.”
SOURCE: Du L. (1992). [The effect of fluorine on the developing human brain]. Chung-hua Ping Li Hsueh Tsa Chih. 21:218-20.

“The significant differences in IQ among these regions suggests that fluoride can exacerbate central nervous lesions and somatic developmental disturbance caused by iodine deficiency. This may be in keeping with fluoride's known ability to cause degenerative changes in central nervous system cells and to inhibit the activities of many enzymes, including choline enzymes, causing disturbance of the nerve impulse.”
SOURCE: Lin Fa-Fu; et al (1991). The relationship of a low-iodine and high-fluoride environment to subclinical cretinism in Xinjiang. Iodine Deficiency Disorder Newsletter Vol. 7. No. 3.

ANIMAL STUDIES - Fluoride's Impact on Brain (Behavior/ Learning/ Memory): (back to top)

"Additional animal studies designed to evaluate reasoning are needed. These studies must be carefully designed to measure cognitive skills beyond rote learning or the acquisition of simple associations, and test environmentally relevant doses of fluoride."
SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p. 187.

"In comparison with control rats, the learning and memory ability of the offspring rats was depressed by high fluoride, low iodine, or the combination of high fluoride and low iodine."
SOURCE: Wang J, et al. (2004). Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. Fluoride 37: 201-208.

"Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.”
SOURCE: Bhatnagar M, et al. (2002). Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice. Indian Journal of Experimental Biology 40: 546-54.

“Administration of sodium fluoride with drinking water produced both behavioural and dental toxicities and not lethality in the present study. A suppression of spontaneous motor activity, a shortening of rota-rod endurance time, a decreased body weight gain and food intake, a suppression of total cholinesterase and acetylcholinesterase activities and dental lesion were observed in test animals.”
SOURCE: Ekambaram P, Paul V. (2001). Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats. Environmental Toxicology and Pharmacology 9(4):141-146.

“The main results showed that the learning capability of mice drinking higher concentration of fluoride presented remarkable deterioration.”
SOURCE: Zhang Z, et al. (2001). [Effects of selenium on the damage of learning-memory ability of mice induced by fluoride]. Wei Sheng Yan Jiu. 30(3):144-6.

“Learning and memory abilities of high-fluoride exposed groups were significantly lower than that of the control group, while the brain ChE activities of high-fluoride exposed groups were significantly higher. Conclusions: High fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant.”
SOURCE: Sun ZR, et al. (2000). Effects of high fluoride drinking water on the cerebral functions of mice. Chinese Journal of Epidemiology 19: 262-263.

“The main results are as follows: the learning ability of mice drinking high concentration of fluoride presented remarkable deterioration... The results suggested that the impairment on the learning capability induced by fluorosis may be closely related with the pathological changes of synaptic structure in the brain of mice.”
SOURCE: Zhang Z, et al. (1999). [Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice] [Article in Chinese]. Wei Sheng Yan Jiu 28(4):210-2.

“Sodium fluoride treatment suppressed spontaneous motor activity But no change was observed in the motor coordination of these animals. A suppression of spontaneous motor activity suggests that fluoride has, by a central action, inhibited motivation of these animals to exhibit locomotor behavior.”
SOURCE: Paul V, et al. (1998). Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats. Environmental Toxicology and Pharmacology 6: 187–191.

“This study demonstrates a link between certain fluoride exposures and behavioral disruption in the rat. The effect on behavior varied with the timing of exposure during CNS development. Behavioral changes common to weanling and adult exposures were different from those after prenatal exposures... Experience with other developmental neurotoxicants prompts expectations that changes in behavioral function will be comparable across species, especially humans and rats... [A] generic behavioral pattern disruption as found in this rat study can be indicative of a potential for motor dysfunction, IQ deficits and/or learning disabilities in humans.”
SOURCE: Mullenix P, et al. (1995). Neurotoxicity of Sodium Fluoride in Rats. Neurotoxicology and Teratology 17:169-177.

ANIMAL STUDIES - Fluoride's Impact on Brain: (back to top)

"Lipids and phospholipids, phosphohydrolases and phospholipase D, and protein content have been shown to be reduced in the brains of laboratory animals subsequent to fluoride exposure. The greatest changes were found in phosphatidylethanolamine, phosphotidylcholine, and phosphotidylserine. Fluorides also inhibit the activity of cholinesterases, including acetylcholinesterase. Recently, the number of receptors for acetylcholine has been found to be reduced in regions of the brain thought to be most important for mental stability and for adequate retrieval of memories.

It appears that many of fluoride’s effects, and those of the aluminofluoride complexes are mediated by activation of Gp, a protein of the G family. G proteins mediate the release of many of the best known transmitters of the central nervous system. Not only do fluorides affect transmitter concentrations and functions but also are involved in the regulation of glucagons, prostaglandins, and a number of central nervous system peptides, including vasopressin, endogenous opioids, and other hypothalamic peptides. The AlFx binds to GDP and ADP altering their ability to form the triphosphate molecule essential for providing energies to cells in the brain. Thus, AlFx not only provides false messages throughout the nervous system but, at the same time, diminishes the energy essential to brain function.

Fluorides also increase the production of free radicals in the brain through several different biological pathways. These changes have a bearing on the possibility that fluorides act to increase the risk of developing Alzheimer’s disease. Today, the disruption of aerobic metabolism in the brain, a reduction of effectiveness of acetylcholine as a transmitter, and an increase in free radicals are thought to be causative factors for this disease. More research is needed to clarify fluoride’s biochemical effects on the brain."
SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p. 186.

"Studies of rats exposed to NaF or AlF3 have reported distortion in cells in the outer and inner layers of the neocortex. Neuronal deformations were also found in the hippocampus and to a smaller extent in the amygdala and the cerebellum. Aluminum was detected in neurons and glia, as well as in the lining and in the lumen of blood vessels in the brain and kidney. The substantial enhancement of reactive microglia, the presence of stained intracellular neurofilaments, and the presence of IgM observed in rodents are related to signs of dementia in humans. The magnitude of the changes was large and consistent among the studies."
SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C. p. 187.

"In the present study, levels of glutathione and activities of catalase, GSH-PX, and SOD were significantly decreased, whereas lipid peroxide levels were enhanced in the brain of adult rats by treatment with NaF, As2O, or NaF + As2O3, in agreement with earlier reports."
SOURCE: Chinoy NJ, et al. (2004). Biochemical effects of sodium fluoride and arsenic trioxide toxicity and their reversal in the brain of mice. Fluoride 37: 80-87.

"The histology of the cerebral hemisphere was altered by NaF and/or Arsenic trioxide [As2O3] treatment for 30 days, wherein the effect by As2O3 was greater than by NaF treatment. This result is in agreement with others... The reduced brain acetylcholinesterase (AChE) enzyme activity observed in the present study corroborates data of others in rats exposed for three months to arsenic trioxide and in the brain of NaF-treated mice and rats as compared to controls... The DNA and RNA levels in the cerebral hemisphere were significantly lower in NaF and/or As2O3-treated mice in the present study, which could affect brain function. The ingestion of the antidotes vitimans C and E as well as calcium phosphate, either indivdually or in combination, during the 30-day withdrawal period resulted in significant recovery, probably due to the antioxidant-properties of vitamins C and E and modulation of fluoride-induced toxicity in rats by calcium."
SOURCE: Shah SD, Chinoy NJ. (2004). Adverse effects of fluoride and/or arsenic on the cerebral hemisphere of mice and recovery by some antidotes. Fluoride 37: 162-171.

"Superoxide dismutase (SOD) activity and the malondialdehyde (MDA) content in the brain of the combined high fluoride and low iodine group were significantly higher during and at the end of the 90-day period than in the control group, but the SOD/MDA ratio in this high fluoride and low iodine group was consistently lower than in the control group. These results suggest that [oxidative] stress from high fluoride and low iodine is one of the causes of reduction in learning and memory in offspring rats."
SOURCE: Wang J, Ge Y, Ning H, Wang S. (2004). Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. Fluoride 37: 201-208.

"Brain protein was decreased by low iodine and even more by the combined interaction of high fluoride and low iodine. The activity of cholinesterase (ChE) in the brain was affected to some extent by high fluoride and low iodine but was especially affected by high fluoride and low iodine together."
SOURCE: Wang J, et al. (2004). Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. Fluoride 37: 201-208.

“Recently, we have detected the alterations of nicotinic acetylcholine receptors (nAChRs) in rat brains and PC12 cells affected by fluoride toxicity... [O]xidative stress, including protein oxidation of the receptors and lipid peroxidation in cellular membrane, might be a mechanism of the deficit of the receptors.”
SOURCE: Shan KR, Qi XL, Long YG, Wang YN, Nordberg A, Guan ZZ. (2004). Decreased nicotinic receptors in PC12 cells and rat brains influenced by fluoride toxicity—a mechanism relating to a damage at the level in post-transcription of the receptor genes. Toxicology 200: 169–177.

“Fluorosis had obvious influence on phospholipid and fatty acid composition in brain cells of rats, and its mechanism might be associated with action of lipid peroxidation, and 0.03 mg/L KI (potassium iodine) is the optimal concentration for the antagonistic action with this influence from fluorosis.”
SOURCE: Shen X, Zhang Z, Xu X. (2004). [Influence of combined iodine and fluoride on phospholipid and fatty acid composition in brain cells of rats] Wei Sheng Yan Jiu. 33:158-61.

“These findings suggest that selective decreases in the number of nAChRs may play an important role in the mechanism(s) by which fluoride causes dysfunction of the central nervous system.”
SOURCE: Chen J, Shan KR, Long YG, Wang YN, Nordberg A, Guan ZZ. (2003). Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride. Toxicology 183: 235-42.

“These neurotoxic changes in the brain suggested that there was a direct action of fluoride upon the nerve tissue which was responsible for central nervous system problems such as tremors, seizures, and paralysis indicating brain dysfunction seen at the two highest doses."
SOURCE: Shashi A. (2003). Histopathological investigation of fluoride-induced neurotoxicity in rabbits. Fluoride 36: 95-105.

“CONCLUSION: Fluoride may go through the blood-brain barrier and accumulate in rat hippocampus, and inhibit the activity of cholinesterase.”
SOURCE: Zhai JX, et al. (2003). [Studies on fluoride concentration and cholinesterase activity in rat hippocampus]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21:102-4.

“Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenerative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg).”
SOURCE: Bhatnagar M, et al. (2002). Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice. Indian Journal of Experimental Biology 40: 546-54.

“The DNA damage in pallium neurons in rats of the fluoride group was much more serious compared with those of the control group...Sodium fluoride could induce DNA damage and apoptosis in rats brain.”
SOURCE: Chen J, Chen X, Yang K, Xia T, Xie H. (2002). [Studies on DNA damage and apoptosis in rat brain induced by fluoride]. Zhonghua Yu Fang Yi Xue Za Zhi 36: 222-224.

“In order to investigate the molecular mechanism(s) underlying brain dysfunction caused by chronic fluorosis, neuronal nicotinic acetylcholine receptors (nAChRs) in the brain of rats receiving either 30 or 100 ppm fluoride in their drinking water for 7 months were analyzed in the present study employing ligand binding and Western blotting... Since nAChRs play major roles in cognitive processes such as learning and memory, the decrease in the number of nAChRs caused by fluoride toxicity may be an important factor in the mechanism of brain dysfunction in the disorder.”
SOURCE: Long YG, Wang YN, Chen J, Jiang SF, Nordberg A, Guan ZZ. (2002). Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain. Neurotoxicology and Teratology 24:751-7.

“These results suggest that fluoride enhances oxidative stress in the brain, thereby disturbing the antioxidant defense of rats. Increased oxidative stress could be one of the mediating factors in the pathogenesis of fluoride toxicity in the brain.”
SOURCE: Shivarajashankara YM , et al. (2002). Brain lipid peroxidation and antioxidant systems of young rats in chronic fluoride intoxication. Fluoride 35: 197-203.

“rats exposed to 100 ppm fluoride showed significant neurodegenerative changes in the hippocampus, amygdala, motor cortex, and cerebellum... These histological changes suggest a toxic effect of high-fluoride intake during the early developing stages of life on the growth, differentiation, and subcellular organization of brain cells in rats.”
SOURCE: Shivarajashankara YM , et al. (2002). Histological changes in the brain of young fluoride-intoxicated rats. Fluoride 35: 12-21.

“The extent of DNA damage in the fluoride + selenium + zinc group was significantly slighter than that in the fluoride group (P <> fluoride and selenium could induce DNA damage in pallium neural cells of rats respectively.”
SOURCE: Chen J, Chen X, Yang K. (2000). [Effects of selenium and zinc on the DNA damage caused by fluoride in pallium neural cells of rats]. Wei Sheng Yan Jiu. 29: 216-7.

“This study therefore shows that both brain and muscle are affected by fluoride with inhibition of some enzymes associated with free-radical metabolism, energy production and transfer, membrane transport, and synaptic transmission, but with an enhanced activity of XOD.”
SOURCE: Lakshmi Vani M, Pratap Reddy K. (2000). Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice. Fluoride 33: 17-26.

“There is a tendency for neurone apoptosis in chronic fluorosis in rats. It is most evident with changes in pathology. It is not likely that only one form of neurone damage exist in the process of chronic fluorosis. There are recessive changes and apoptosis in the process at the same time.”
SOURCE: Lu XH, et al. (2000). Study of the mechanism of neurone apoptosis in rats from the chronic fluorosis. Chinese Journal of Epidemiology 19: 96-98.

“Over uptake of fluoride for a long term could cause potential increase in the level of oxidative stress in the brain tissue.”
SOURCE: Shao Q, Wang Y, Guan Z. (2000). [Influence of free radical inducer on the level of oxidative stress in brain of rats with fluorosis]. Zhonghua Yu Fang Yi Xue Za Zhi 34:330-2.

\“It was concluded that aluminium interferes with the metabolism of the neuronal cytoskeleton and that this interference is potentiated by fluoride.”
SOURCE: van der Voet GB, et al. (1999). Fluoride enhances the effect of aluminium chloride on interconnections between aggregates of hippocampal neurons. Archives of Physiology and Biochemistry 107:15-21.

"[T]he thickness of post-synaptic density (PSD) was decreased, and the width of synaptic cleft was remarkably increased. The results suggested that the impairment on the learning capability induced by fluorosis may be closely related with the pathological changes of synaptic structure in the brain of mice.”
SOURCE: Zhang Z, et al. (1999). [Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice] [Article in Chinese]. Wei Sheng Yan Jiu 28:210-2.

“The results demonstrate that the contents of phospholipid and ubiquinone are modified in brains affected by chronic fluorosis and these changes of membrane lipids could be involved in the pathogenesis of this disease.”
SOURCE: Guan ZZ, Wang YN, Xiao KQ, Dai DY, Chen YH, Liu JL, Sindelar P, Dallner G. (1998). Influence of chronic fluorosis on membrane lipids in rat brain. Neurotoxicology and Teratology 20: 537-542.

“While the small amount of AlF in the drinking water of rats required for neurotoxic effects is surprising, perhaps even more surprising are the neurotoxic results of NaF at the dose given in the present study [1.0 ppm F]... The results of the present study indicate that more intensive neuropathological evaluations of F effects on brain may prove to be of value... In summary, chronic administration of AlF and NaF in the drinking water of rats resulted in distinct morphological alterations in the brain, including effects on neurons and cerebrovasculature.”
SOURCE: Varner JA, et al. (1998). Chronic administration of aluminum-fluoride and sodium-fluoride to rats in drinking water: Alterations in neuronal and cerebrovascular integrity. Brain Research 784: 284-298.

“These results indicate that fluoride may penetrate the blood brain barrier, interact with AChE located on cell membranes, and interfere with their physiological functions and thus induce the neurotoxicities.”
SOURCE: Zhao XL, Wu JH. (1998). Actions of sodium fluoride on acetylcholinesterase activities in rats. Biomedical and Environmental Sciences 11(1):1-6.

“The metabolism of brain phospholipid might be interfered by fluoride accumulated in brain tissue, which is related with the degeneration of neuron. The changes of brain phospholipid could be involved in the pathogenesis of chronic fluorosis.”
SOURCE: Guan Z, Wang Y, Xiao K. (1997). [Influence of experimental fluorosis on phospholipid content and fatty acid composition in rat brain]. Zhonghua Yi Xue Za Zhi. 77: 592-6.

“Neuronal abnormalities were observed in the NaF treated animals- especially in the deeper cell layers... The NaF treatment also produced distortions of cells and, in some rats, cell losses could be demonstrated in particular brain regions. Both AlF3 and NaF induced vascular inclusions, although of a different character...”
SOURCE: Issacson R, et al. (1997). Toxin-induced blood vessel inclusions caused by the chronic administration of aluminum and sodium fluoride and their implications for dementia. Annals of the New York Academy of Science 825: 152-166.

“Coenzyme Q content of brain tissue in rats fed with fluorine-containing water decreased at early stage of fluorosis, but increased significantly at late stage. It is speculated that changes in content of coenzyme Q could correlate with changes in free radical levels induced by fluorine.”
SOURCE: Wang Y, Guan Z, Xiao K. (1997). [Changes of coenzyme Q content in brain tissues of rats with fluorosis]. Zhonghua Yu Fang Yi Xue Za Zhi. 31: 330-3.

“Excessive fluoride intake decreased 5-hydroxy indole acetic acid and increased norepinephrine in rat brain.”
SOURCE: Li Y, et al. (1994). [Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism] Hua Hsi I Ko Ta Hsueh Hsueh Pao. 25(2):188-91.

“The results reported here indicate that fluoride has a specific effect on the synthesis of proteins in the brain which may lead to degenerative changes in the form of ballooning degeneration of neurons, various degrees of loss of nisal substance, and changes in the purkinje cells of the cerebellar cortex. Such changes would provide a plausible explanation for some of the diverse neruological complaints in arms and legs such as numbness, muscle spasms and pains, tenaniform convulsions, and spastic paraplegia, encountered in patients with skeletal fluorosis."
SOURCE: Shashi A, et al. (1994). Effect of long-term administration of fluoride on levels of protein, free amino acids and RNA in rabbit brain. Fluoride 27: 155-159.

“The neurotoxic effect of fluoride on lipid content of brain was assessed in rabbits during experimental fluorosis... Fluoride exerts an inhibitory effect on the free fatty acids in brain of both sexes. The relevance of these results in experimental fluorosis is discussed.”
SOURCE: Shashi A. (1992). Studies on alterations in brain lipid metabolism following experimental fluorosis. Fluoride 25:77-84.

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Fluoride Deception

2007-12-07T12:09:00.000-08:00

If you still believe the myth that fluoride is good for your children’s (and your) teeth, think again. There are a vast number of scientific research studies confirming the opposite – that fluoride is a toxin that is extremely detrimental to your body, your brain, and even to your teeth.

One of the most active research areas today is fluoride’s ability to damage your brain. Recent human studies from China have confirmed the results of previous animal studies; that elevated fluoride exposure leads to reduced I.Q. in children.

Cognitive ability is further reduced if your child is deficient in iodine.

Prior to this, more than 30 animal studies produced since 1992 have reported impairment in learning and memory processes among animals treated with fluoride.

Even at levels as low as 1ppm (part per million), studies have demonstrated direct toxic effects on brain tissue, including:

reduction in lipid content
impaired anti-oxidant defense systems
damage to your hippocampus
damage to your purkinje cells
increased uptake of aluminum
formation of beta-amyloid plaques (the classic brain abnormality in Alzheimer's disease)
accumulation of fluoride in your pineal gland.

Sources:

Fluoride Action Network

, it’s truly remarkable that it’s NOT considered a scientific consensus by now. It truly amazes me that the medical (and dental) communities are so stubbornly resistant to connect the dots when it comes to the skyrocketing increase of cognitive decline in adults (Alzheimer’s and various dementia’s), and (ADD, ADHD, depression and learning disabilities of all kinds).

Fluoridating drinking water for dental health is a swindle of massive proportions.

As award-winning journalist, Christopher Bryson details in his book, The Fluoride Deception, fluoridating water began in the mid 1940’s as a solution to fluoride pollution, generated by the Atomic Bomb Program, and the aluminum industry.

Starting it off with a simple truth, that a natural form of fluoride is part of the composition of your teeth (organic calcium phosphate), they were able to pull the wool over everyone’s eyes, and convince everyone that drinking toxic chemical fluoride compounds – the waste materials from these fluoride-polluting industries – would be good for children’s teeth. It was sheer genius!

Start with a grain of truth, and end up with a lie the size of the Sahara.

Instead of risking increasing lawsuits from farmers whose crops and cattle were dying downwind, or having to spend enormous amounts of money to dispose of these chemicals safely, they were now able to SELL their waste material as a “health” product! Amazing!

And the cover-up continues to this day. Did you even know that when scientists study fluoride’s toxicity to humans, they study pharmaceutical grade fluoride (same stuff used in antidepressant drugs), but NOT the fluoride compounds actually USED for water fluoridation – the even more toxic waste materials now generated from Florida’s fertilizer industry?

So, in essence, their already detrimental results may in fact be FAR GREATER than currently perceived. Which is already bad enough, considering that basic sodium fluoride, (which is a far simpler toxin than the fluoride compounds used for most water fluoridation) is also used for:

Rat and cockroach poisons
Anesthetics
Hypnotics
Military nerve gas (sarin)

I am currently in the process of finalizing a Special Report on fluoride, so keep your eyes open for it. It and several other special reports on a variety of topics can be found on my site. My fluoride report will cover:

The scam that initiated water fluoridation, and why people believed it
How fluoride destroys your health
What fluorosis really is, and why it’s not merely a “cosmetic defect”
Its more potentially sinister uses, and much more

As I reported in an earlier article, in August 2007 the CDC has been charged with a formal complaint detailing unethical activities, and at the same time the Fluoride Action Network (FAN) released a Statement asking Congress to end water fluoridation in the United States, signed by more than 600 professionals, including a Nobel Prize winner, officers in the Union that represents Environmental Protection Agency professionals, and members of the National Research Council panel on fluoride's toxicology.

By October 2007, they had more than 1,000 professional signatories. If you are a professional, you can add your signature to their Congressional Statement here.

How You Can Keep Your Teeth Healthy Without Fluoride

Fluoride was never your answer in the first place, so don’t fret, thinking that by eliminating this toxin you’ll destroy your child’s teeth (or your own).

Instead, look to your diet for naturally healthy teeth. In fact, most people whose diet includes very little sugar and few processed foods have very low rates of tooth decay. Limiting, or -- along with regular cleanings with your natural dentist -- will ensure that your teeth stay healthy naturally.

You can also protect yourself by using only non-fluoride toothpaste, and not receiving fluoride treatments from your dentist. Certain cements, fillings and bonding materials also contain fluoride, so talk to your dentist about non-fluoride options in those cases.

You definitely should NOT give your child additional fluoride supplements, which some dentists will prescribe if you live in a non-fluoridated area.

Unfortunately, removing fluoride from your drinking water is a far more difficult feat. Whereas some other chemicals added to your drinking water will evaporate, fluoride is not one of them. Neither cooking, food processing, regular filtration, nor digestion will remove fluoride.

The only known way to remove fluoride from water is by using a reverse osmosis filter. A simple carbon filter will not remove fluoride. You should also remember to filter not only the water that you drink, but also the water you use to wash vegetables, make ice cubes, and cook with.

In addition to your kitchen, you might want to consider adding filters in your shower and your tub as well, since you will also absorb contaminations through your skin when you shower or bathe.

I also recommend reading my revealing interview with Christopher Bryson, for more information about the fluoride deception that has plagued the United States for 60 years. It’s time to put an end to the cover-up.

600 Physicians, Dentists, Scientists and Environmentalists Call for an End to Fluoridation

CDC Covering Up Serious Hazards of Water Fluoridation

What Your Dentist Isn’t Telling You About Fluoride